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| 1 | Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer显示文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients. | Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg Dick Wågsäter | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 4 | Attention-driven monocular scene reconstruction for obstacle detection,robot navigation and map building显示文摘 | EINHORN E SCHR(O)TER CH GROSS H M | 2011 | Robotics and Autonomous Systems2011，59，： | 1 |
| 5 | Tomato peel:rare cause of biliary tract obstruction显示文摘 | Hagymási K Péter Z Cs?regh E | | 0，，47： | 1 |
| 6 | Evidence based selection of housekeeping genes显示文摘 | de Jonge H J Fehrmann R S de Bont E S Hofstra R M Gerbens F Kamps W A de Vries E G van der Zee A G te Meerman G J ter Elst A | | 0，，： | 1 |
| 7 | Regional differences in expression of TPH-1,SERT,5-HT(3)and 5-HT(4)receptors in the human stomach and duodenum显示文摘 | Van Lelyveld N Ter Linde J Schipper M E | 2007 | Neurogastroenterol Motil2007，19，5： | 1 |
| 8 | Dissociating anticipation from perception:Acute pain activates default mode network显示文摘 | Ter Minassian A Ricalens E Humbert S | 2013 | Hum Brain Mapp2013，34，9： | 1 |
| 9 | Synergistic actions of nisin,sublethal ultrahigh pressure,and reduced temperature on bacteria and yeast显示文摘 | Ter Steeg P F Hellemons J C Kok A E | 1999 | Appl Environ Microbiol1999，65，： | 1 |
| 10 | Thermal processing of whole soya beans: Studies on the inactivation of antinutritional factors and effects on ileal digestibility in piglets显示文摘 | Qin G Ter Elst E R Bosch M W | 1996 | Anita Feed Sci Tech1996，57，： | 1 |
| 11 | The relationship between evoked potentials and measurements of S-100 protein in cerebrospinal fluid during and after thoracoabdominal aortic aneurysm surgery显示文摘 | van Dongen E P ter Beek H T Schepens M A | 1999 | J Vasc Surg1999，30，2： | 1 |
| 12 | C-reactive protein levels during disease exacerbations and infections in systemic lupus erythematosus:a prospective longitudinal study显示文摘 | ter Borg E J Horst G Limburg P C van Rijswijk M H Kallenberg C G | 1990 | J Rheumatol1990，17，： | 1 |
| 13 | Immediate versus deferred coronary angioplasty in non-ST-elevation acute coronary syndromes 显示文摘 | Riezebos RK Ronner E Ter Bals E | 2009 | Heart2009，95，17： | 1 |
| 14 | Synergistic actions of nisin, sublethal ultrahigh pressure, and reduced temperature on bacteria and yeast显示文摘 | Ter Steeg P F Hellemons J C & Kok A E | 1999 | Applied and Environmental Microbiology1999，65，9： | 1 |
| 15 | Insect immunity:evolutionary roots of the mammalian innate immune system显示文摘 | Péter V (E)va K | 1998 | Immunol Lett1998，62，： | 1 |
| 16 | Structuring of edible oils by alternatives to crystalline fat显示文摘 | PERNETTI M VAN MALSSEN K F FI TER E | 2007 | Current Opinion in Colloid & Interface Science2007，45，12： | 1 |
| 17 | Immediate versus deferred coronary angioplasty in non-ST-elevation acute coronary syndromes显示文摘 | Riezebos RK Ronaer E ter Bals E | | 0，，10： | 1 |
| 18 | Improvement of a chronic rat model for peritoneal dialysis by using heparin-coated catheters显示文摘 | Zareie M Keuning E ter Wee P | 2004 | Adv Perit Dial2004，20，： | 1 |
| 19 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 20 | Central poststroke pain: Current diagnosis and treatment显示文摘 | Has ter M Meresh E Rao M | 2013 | Top Stroke Rehabih 20132013，，： | 1 |
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