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| 1 | Research Progress on the Relationship between Coronary Artery Calcification and Chronic Renal Failure显示文摘 | Jun Lai Gael Akindavyi Qiang Fu Zhi-Liang Li Hui-Min Wang Li-Hua Wen | 2018 | Chinese Medical Journal2018，，5： | 18 |
| 2 | Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model显示文摘目的: 调查胡椒碱,在 Piper nigrum 在场的主要的刺鼻的碱和 Piper longum 的效果,在肿瘤生长和老鼠 4T1 的转移上在 vitro 并且在 vivo 的乳房的癌,并且阐明内在的机制。 | Li-hua LAI Qi-hong FU Yang LIU Kai JIANG Qing-ming GUO Qing-yun CHEN Bin YAN Qing-qing WANG Jian-gen SHEN | 2012 | Acta Pharmacologica Sinica2012，33，4： | 16 |
| 3 | Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies显示文摘Dear Editor,Mutations in the β-globin gene,the essential component of adult hemoglobin(HbA;a2p2),results in either a production of aberrant sickle hemoglobin(HbS)leading to sickle cell disease(SCD)or an insufficient β-globin synthesis leading to β-thalassemia.These two major forms of β-hemoglobinopathies cause impaired erythropoiesis and life-threatening anemia.Clinical evidence has suggested that reaaivation of fetal γ-globin(HBG)gene expression which is normally silenced after birth by certain genetic mutations can ameliorate the clinical course of β-hemoglobinopathies. | Liren Wang Linxi Li Yanlin Ma Handan Hu Qi Li Yang Yang Wenbang Liu Shuming Yin Wei Li Bin Fu Ryo Kurita Yukio Nakamura Mingyao Liu Yongrong Lai Dali Li | 2020 | Cell Research2020，30，3： | 14 |
| 4 | 生物合理设计光系统Ⅱ抑制剂研究(Ⅱ)3-苯甲氨基-2-氰基-3-甲硫基丙烯酸乙酯的晶体及分子结构显示文摘合成了具有良好光合作用抑制活性的标题化合物,测定了其晶体结构.确定了该类化合物的顺反构型,阐明了苯环与氨基间亚甲基对化合物抑制活性的重要作用,解释了氨基氢与酯羰基氧间没有形成氢键的原因. | LIU Hua Yin *, YANG Guang Fu, LU Rong Jian, TAN Hui Fen, YANG Hua Zheng (The Institute of Elemento Organic Chemistry, National Elemento Organic Chemistry Key Laboratory, Nankai University, Tianjin, 300071) LAI Lu Hua (The Institute of Physical Chemist | 1998 | 高等学校化学学报1998，19，6： | 10 |
| 5 | Analysis of Disequilibrium Hybridization in Hybrid and Backcross Progenies of Saccharum officinarum × Erianthus arundinaceus显示文摘Erianthus arundinaceus is an important, closely related genus of Saccharum officinarum L. It is therefore important to understand how the chromosomes are transmitted when it hybridizes with sugarcane. The hybrids and backcross progenies of S. officinarum and E. arundinaceus and their parents were used for Karyotype analysis and to study the law of chromosome transmission. The results showed that the somatic chromosome number of both of the E. arundinaceus Hainan92-105 and Hainan92-77 were 2n = 60 = 60sm, belonging to type 1A, and the BC1 YC01-21 was 2n = 104 = 100m + 4sm, belonging to type 2C. The other six tested clones belonged to type 2B. The both F1s YC96-66 and YC96-40 that originated from Badila (2n = 80 = 70m + 10sm) with E. Arundinaceus were 2n = 70 = 68m + 2sm, which suggests an n + n transmission. The cross between YC96-66 (female parent) and CP84-1198 (male parent, 2n = 120 = 114m + 6sm) also followed the same genetic law and the somatic chromosome number of their progeny, YC01-3 (2n = 105 = 95m + 10sm). The cross derived from YC96-40 (female) and CP84-1198 (male), YC01-21 had 2n = 104 = 100m + 4sm chromosomes, following the same genetic law of n + n. However, YC01-36 had 2n = 132 = 130m + 2sm chromosomes, which suggests a 2n + n chromosome transmission. It can be inferred that the inheritance of chromosomes was very complex in the BC1. The difference in chromosome number between clones was as high as 28. This could be explained by the 2n + n transmission of chromosomes. In addition, as there was not be a regular number of haploids, this phenomenon is termed as disequilibrium hybridization. | DENG Zu-hu ZHANG Mu-qing LIN Wei-le CHENG Fu ZHANG Chui-ming LI Yu-chang LAI Li-ping LIN Yan-quan CHEN Ru-kai | 2010 | Agricultural Sciences in China2010，9，9： | 9 |
| 6 | Influence of blood glucose on the expression of glucose transporter proteins 1 and 3 in the brain of diabetic rats显示文摘到大脑的从血的葡萄糖的交货包含的背景它越过血大脑障碍(BBB ) 的 endothelial 房间的经过,它被 facilitative 葡萄糖 transporter 蛋白质调停 1 (GLUT1 ) ,然后越过神经房间膜,它被 GLUT3 调停。试图在这些的表示上评估多糖症的动态影响的这研究由在糖尿病的一个老鼠模型在不同的血葡萄糖层次在大脑测量他们的表示充斥。这可能帮助决定在糖尿病的 apoplexy.Methods 糖尿病 mellitus 的治疗的合适的血葡萄糖阀值水平在 30 只老鼠与 streptozotocin (STZ ) 被导致。老鼠随机被划分成 3 个组:没有血葡萄糖控制(组 DM1 ) 的糖尿病的组,与低剂量胰岛素(组 DM2 ) 对待的糖尿病的老鼠,和与高度对待的糖尿病的老鼠开胰岛素(组 DM3 ) 。GLUT1 和 GLUT3 的 mRNA 和蛋白质层次是由反向的 transcriptase 聚合酶链反应(RT-PCR ) 和 immunohistochemistry 的 assayed, respectively.Results 与正常控制老鼠相比, GLUT1 mRNA 被 46.08% 减少, 29.80% ,(P0.01 )19.22% 分别地在 DM1, DM2,和 DM3 组织;并且 GLUT3 mRNA 被 75.00% , 46.75% ,和 17.89% 减少(P0.01 ) 分别地在 DM1, DM2,和 DM3 组织。许多 GLUT1 和 GLUT3 蛋白质与血葡萄糖水平(P0.01 ) 有否定关联。在糖尿病的老鼠的大脑的 microvessels 的密度没与在 mRNA 和蛋白质的长期的多糖症 downregulates GLUT1 和 GLUT3 表示在老鼠大脑铺平的正常 rats.Conclusions 相比显著地变化,它不由于 microvessels 的密度的减少。GLUT1 和 GLUT3 表示的 downregulation 可能是身体的适应反应阻止过多的葡萄糖进入可以导致房间损坏的房间。 | HOU Wei-kai XIAN Yu-xin ZHANG Li LAI Hong HOU Xin-guo XU Yu-xin YU Ting XU Fu-yu FU Chun-li ZHANG Wen-wen CHEN Li | 2007 | Chinese Medical Journal2007，，19： | 8 |
| 7 | Effects of neuregulin-1 on autonomic nervous system remodeling post-myocardial infarction in a rat model显示文摘Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocardial infarction(MI). Increasing evidence indicates that neuregulin-1(NRG-1) improves cardiac function following heart failure. Since its impact on cardiac function and neural remodeling post-MI is poorly understood, we aimed to investigate the role of NRG-1 in autonomic nervous system remodeling post-MI. Forty-five Sprague-Dawley rats were equally randomized into three groups: sham(with the left anterior descending coronary artery exposed but without ligation), MI(left anterior descending coronary artery ligation), and MI plus NRG-1(left anterior descending coronary artery ligation followed by intraperitoneal injection of NRG-1(10 μg/kg, once daily for 7 days)). At 4 weeks after MI, echocardiography was used to detect the rat cardiac function by measuring the left ventricular end-systolic inner diameter, left ventricular diastolic diameter, left ventricular end-systolic volume, left ventricular end-diastolic volume, left ventricular ejection fraction, and left ventricular fractional shortening. m RNA and protein expression levels of tyrosine hydroxylase, growth associated protein-43(neuronal specific protein), nerve growth factor, choline acetyltransferase(vagus nerve marker), and vesicular acetylcholine transporter(cardiac vagal nerve fiber marker) in ischemic myocardia were detected by real-time PCR and western blot assay to assess autonomous nervous remodeling. After MI, the rat cardiac function deteriorated significantly, and it was significantly improved after NRG-1 injection. Compared with the MI group, m RNA and protein levels of tyrosine hydroxylase and growth associated protein-43, as well as choline acetyltransferase m RNA level significantly decreased in the MI plus NRG-1 group, while m RNA and protein levels of nerve growth factor and vesicular acetylcholine transporters, as well as choline acetyltransferase protein level slightly decreased. Our results indicate that NRG-1 can improve cardiac function and regulate sympathetic and vagus nerve remodeling post-MI, thus reaching a new balance of the autonomic nervous system to protect the heart from injury. | Xin Lai Liang Zhong Hai-xia Fu Song Dang Xin Wang Ning Zhang Gao-ke Feng Zi-qiang Liu Xi Wang Long Wang | 2017 | Neural Regeneration Research2017，12，11： | 7 |
| 8 | Sustainable Management of Rice Insect Pests by Non-Chemical-Insecticide Technologies in China显示文摘Chemical pesticides play crucial roles in the management of crop diseases and pests. However, excessive and irrational use of pesticides has become a major concern and obstacle to sustainable agriculture. As a result, the quality and security of agricultural products are reduced, and the ecological and environmental integrities are threatened. Recently, environment-friendly pest management measures have been introduced and adopted to manage rice insect pests and reduce the use of insecticides. This paper reviewed the advancements in development and application of non-chemical technologies for insect pest management during rice production in China. | XU Hong-xing YANG Ya-jun LU Yan-hui ZHENG Xu-song TIAN Jun-ce LAI Feng-xiang FU Qiang LU Zhong-xian | 2017 | Rice science2017，24，2： | 6 |
| 9 | Posthepatectomy HBV Reactivation in Hepatitis B–Related Hepatocellular Carcinoma Influences Postoperative Survival in Patients With Preoperative Low HBV-DNA Levels显示文摘 | Gang Huang Eric C. H. Lai Wan Yee Lau Wei-ping Zhou Feng Shen Ze-ya Pan Si-yuan Fu Meng-chao Wu | 2013 | Annals of Surgery2013，，3： | 5 |
| 10 | Novel ionic liquids as reaction medium for atom transfer radical polymerization of methyl methacrylate显示文摘Atom transfer radical polymerization (ATRP) of methyl methacrylate (MMA) employing ethyl 2-bromoisobutyrate (EBiB)/ CuBr as the initiating system was investigated at 50℃ in the absence of any additional ligand in the three room temperature ionic liquids (RTIL_s), 1-methyl-imidazolium acetate ([mim][CH_3COO]), 1-methylimidazolium propionate ([mim][CH_3CH_2COO]) and 1-methylimidazolium butyrate ([mim][CH_3CH_2CH_2COO]), respectively. All the polymerization in the three RTILs proceeded in a well-controlled manner. The sequence of the apparent polymerization rate constants was kapp([mim][CH_3COO]) > kapp([mim] [CH_3CH_2COO]) > kapp ([mim][CH_3CH_2CH_2COO]). | Guo Qiao Lai Fu Min Ma Zi Qiang Hu Hua Yu Qiu Jian Xiong Jiang Ji Rong Wu Li Min Chen Lian Bin-Wu | 2007 | Chinese Chemical Letters2007，18，5： | 4 |
| 11 | A TRANSFER FORECASTING MODEL FOR CONTAINER THROUGHPUT GUIDED BY DISCRETE PSO显示文摘 | XIAO Jin XIAO Yi FU Julei LAI Kin Keung | 2014 | Journal of Systems Science & Complexity2014，27，1： | 4 |
| 12 | An Improvement to Multiple Criteria ABC Inventory Classification Using Shannon Entropy显示文摘This paper extends the Ng-model [Ng, 2007] for multiple criteria ABC inventory classification based upon Shannon entropy. The proposed approach determines the common weights associated with all criteria importance rankings, and provides a comprehensive scoring scheme by aggregating all rankings of the criteria importance. A numerical illustration is presented to compare the model with previous studies. | ZHENG Shanshan FU Yelin LAI Kin Keung LIANG Liang | 2017 | Journal of Systems Science & Complexity2017，30，4： | 4 |
| 13 | Microanatomy of the spermatic cords during microsurgica inguinal varicocelectomy: initial experience in Asian met显示文摘腹股沟的精索的 microanatomy 从来没在亚洲被报导过。这研究的目的是在精索描述静脉,动脉和 lymphatics 的数字和关系并且在亚洲男人澄清管 deferens 的地点。收到一位单身的外科医生从 2011 年 4 月执行到 2012 年 7 月的 79 主要 microsurgical varicocelectomies 的 51 个病人被学习。在腹股沟的 microsurgical varicocelectomy 期间保存的内部、外部的精子的静脉,阴囊的动脉和淋巴的隧道的数字被记录。在权利和左脉管的解剖之间的关系在双边的 varicocelectomies 期间被评估。数据证明那个平均数 1.5 ± 数; 0.9 根动脉, 5.6 ± 2.2 根精子的静脉和 3.6 ± 1.9 lymphatics 在修理期间被识别。内部精子的动脉被支持者静脉的稠密的建筑群在 81.2 % 包围;案例。外部精子的静脉或静脉在 60.8 % 被发现;案例。管 deferens 可以在内部精子的扁带以内被包含。结果建议静脉的数字可能是高度可变的,不到那些在英语文学报导,但是正确、左的精索的腹股沟的 microanatomy 有某类似。进一步的研究被保证澄清我们的结果。 | Xue-Ke Wang Hong-Zhen Wang Ding-Jun Fu Ming-Kuen Lai | 2012 | Asian Journal of Andrology2012，14，6： | 4 |
| 14 | Comparison of outcomes after human leukocyte antigen-matched and haploidentical hematopoietic stem-cell transplantation for multiple myeloma显示文摘Background:Allogeneic stem-cell transplantation (SCT) is a well-established immunotherapeutic strategy for multiple myeloma (MM) with a potent and often sustained graft-vs.-myeloma effect.This multicenter investigation aimed to analyze the complications and survival of haploidentical SCT in patients with MM,and compare the main outcomes with matched-related donors (MRDs).Methods:Haploidentical and MRD SCT was identified from a cohort of 97 patients with MM who received a myeloablative transplantation in 13 hospitals from May 2001 to December 2017.A matched-pair analysis was designed.For each haplo recipient,the recipients were randomly selected from the MRD group and were matched according to the following criteria:year of the hematopoietic SCT (±2 years),disease status at transplantation,and the length of follow-up.ults:Seventy cases received MRD and 27 received haploidendcal transplantation.The two groups showed no significant ifferences regarding age,gender,cytogenetic risk,and diagnostic stage.The cumulative incidences of non-relapse mortality (NRM) at1 and 3 years based on donor type were 20.5%(95% confidence interval [CI],10.90-30.10%) and 24.2%(95% CI,13.81-34.59%) for the MRD group and 16.80%(95% CI,1.71-31.89%) and 28.70%(95% CI,8.71-48.69%) for the haplo group,respectively.Cumulative incidence of NRM did not differ significantly between the two groups (x2 =0.031,P =0.861).The cumulative incidences of progression-free survival (PFS) and 1 year and 3 years by type of donors were 59.8 %(95 % CI,48.24-71.36 %) and 45.4 %(95 % CI,33.44-57.36%),and 65.6%(95% CI,47.18-84.02%) and 26.8%(95% CI,7.59-46.01%) for MRD and haploidentical donor,respectively.Cumulative incidence of PFS did not differ significantly between the two groups (x2 =0.182,P =0.670).In multivariate analyses,no statistically significant differences were observed between haploidentical and MRD for relapse,NRM,PFS,and overall survival.There were no statistically differences on main outcomes after haploidentical and MRD.Conclusion:Haploidentical SCT could be performed safely and feasibly for patients with MM in need. | Yao Chen Wei-Jun Fu Lan-Ping Xu Han-Yun Ren Yong-Rong Lai Dai-Hong Liu Lin Liu Zi-Min Sun Yuan-Bin Wu Xin Wang Ling-Hui Xia Ming Jiang Tong-Lin Hu Ding-Ming Wan Xiao-Jun Huang | 2019 | Chinese Medical Journal2019，，15： | 4 |
| 15 | Rapid identification of Dendrobium officinale using Loop-Mediated Isothermal Amplification (LAMP) method显示文摘Dendrobium officinale is not only an ornamental plant, but also a valuable medicinal herb that is widely used in traditional Chinese medicine. However, distinguishing D. officinale from other Dendrobium species is usually a difficult task. In this study,we developed a rapid identification protocol for D. officinale using the loop-mediated isothermal amplification(LAMP) method. A set of primers were specifically designed to detect a modified internal transcribed spacer region of D. officinale at 65 ℃ within 40 min after adding SYBR~? Green I, which was used for the detection of D. officinale. Unlike commonly used adulterants, reaction mixtures containing D. officinale DNA changed from orange to green, and this color change was easily observed with the naked eye. Thus, this methodology can be used to accurately differentiate D. officinale from other Dendrobium species, is quick as all D. officinale samples were amplified within 40 min, and specific as samples of the adulterants were not amplified. The specificity of this LAMP-based method was confirmed by testing 17 samples of D. officinale and 32 adulterant samples from other Dendrobium species. This LAMP-based rapid identification method does not require expensive equipment or specialized techniques and can be used in field surveys for accurate and fast on-site identification. | YANG Lu WU Wen-Ru ZHOU Hua LAI Hui-Li FU Fei | 2019 | Chinese Journal of Natural Medicines2019，17，5： | 4 |
| 16 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 17 | β-Cypermethrin and its metabolite 3-phenoxybenzoic acid induce cytotoxicity and block granulocytic cell differentiation in HL-60 cells显示文摘 | Bingnan He Xia Wang Lai Wei Baida Kong Yuanxiang Jin Xiaoxian Xie Zhengwei Fu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 3 |
| 18 | Synthesis of O-glycosylα-aryl nitrones显示文摘伪 - 芳基 nitrone 是 nitrones 的最有用的类型之一并且广泛地在最近的年里被探索了。然而,糖一半以前没被介绍进这些分子。我们这里在苯经由代替 N 的 hydroxylamine 和芳基醛 glycosides 的冷凝作用介绍了伪 - 芳基 nitrone O-glycosides 的有效合成。 | Ying Fu Huai Yuan Zhang Yan Hua Liu Xue Feng Li Dan Feng Huang Yu Lai Hu | 2010 | Chinese Chemical Letters2010，21，9： | 3 |
| 19 | Cgr1,a ripe rot resistance QTL in Vitis amurensis‘Shuang Hong’grapevine显示文摘Ripe rot is a serious grapevine disease in Vitis L.and Muscadinia(Planch.)Small.However,resistance to this disease has been reported in some oriental Vitis species.To identify resistance-related Quantitative Trait Loci(QTLs)from the Chinese grape species V.amurensis,an F1 population of V.vinifera‘Cabernet Sauvignon’×V.amurensis‘Shuang Hong’was used to map the ripe rot resistance loci expected in‘Shuang Hong’grape.A total of 7598 single nucleotide polymorphisms(SNPs)between the parents were identified in our previous study,and 934 SNPs were selected for genetic map construction.These SNPs are distributed across the 19 chromosomes covering a total of 1665.31 cM in length,with an average of 1.81 cM between markers.Ripe rot resistance phenotypes among the hybrids were evaluated in vitro using excised leaves for three consecutive years from 2016 to 2018;a continuous variation was found among the F1 hybrids,and the Pearson correlation coefficients of the phenotypes scored in all three years were significant at the 0.01 level.Notably,the first QTL reported for resistance to grape ripe rot disease,named Cgr1,was identified on chromosome 14 of‘Shuang Hong’grapevine.Cgr1 could explain up to 19.90%of the phenotypic variance.In addition,a SNP named‘np19345’was identified as a molecular marker closely linked to the peak of Cgr1 and has the potential to be developed as a marker for the Cgr1 resistance haplotype. | Peining Fu Quanyou Tian Gongti Lai Rongfang Li Shiren Song Jiang Lu | 2019 | Horticulture Research2019，6，1： | 3 |
| 20 | Endoscopic balloon dilatation is a safe method in the management of common bile duct stones显示文摘 | C.-K Lin K.-H Lai H.-H Chan W.-L Tsai E.-M Wang M.-C Wei M.-T Fu C.-C Lo P.-I Hsu G.-H Lo | 2003 | Digestive and Liver Disease2003，，1： | 3 |
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