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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Earthquake-induced soft-sediment deformation structures in the Mesoproterozoic Wumishan Formation,North China,and their geologic implications显示文摘Soft-sediment structures are key to defining seismites. Two soft-sediment deformation horizons, bounded by undeformed carbonate strata, have been found in the Wumishan Formation in the Jumahe region, 175 km southwest of Beijing. One is in the lowest part of Wumishan Formation; and the other is in the uppermost part of Litho-member I. The soft-sediment structures in these two horizons fall into three categories: mould-and-sag structures, hydraulic shatterings and liquefaction dikes. The mould-and-sag structures are divided into two types: one developed in tidal-flat sediments, accompa-nied by many liquefaction-related structures and characterized by autochthonous post-earthquake sediments in sags, and the other type developed in deep-water environments, is not associated with liquefaction structures, and is overlain immediately by seismogenic tsunamites. The hydraulic shat-terings are composed of pockets of fluidization conglomerate, sand intrusions, and syndepositional faults. The liquefaction dikes fall into two categories: hydraulic-fracturing dikes and lateral-spreading dikes. The former are steep, planar, and pinch out upwards. The latter are snake-like and characterized by no diapir-related drag structures in surrounding rocks. Examination of the attitudes and strati-graphic positions of these structures suggests that these soft-sediment structures are seismogenic, and consequently, are seismites. Most seismites in the Wumishan Formation are developed near the former western, margin fault of Yanliao rift. This occurrence suggests that they could be related to movements on this fault. Other geological implications are discussed. | ZHANG ChuanHeng WU ZhengJie GAO LinZhi WANG Wei TIAN YanLin MA Chao | 2007 | Science China Earth Sciences2007，50，3： | 15 |
| 3 | Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies显示文摘Dear Editor,Mutations in the β-globin gene,the essential component of adult hemoglobin(HbA;a2p2),results in either a production of aberrant sickle hemoglobin(HbS)leading to sickle cell disease(SCD)or an insufficient β-globin synthesis leading to β-thalassemia.These two major forms of β-hemoglobinopathies cause impaired erythropoiesis and life-threatening anemia.Clinical evidence has suggested that reaaivation of fetal γ-globin(HBG)gene expression which is normally silenced after birth by certain genetic mutations can ameliorate the clinical course of β-hemoglobinopathies. | Liren Wang Linxi Li Yanlin Ma Handan Hu Qi Li Yang Yang Wenbang Liu Shuming Yin Wei Li Bin Fu Ryo Kurita Yukio Nakamura Mingyao Liu Yongrong Lai Dali Li | 2020 | Cell Research2020，30，3： | 14 |
| 4 | Acupuncture preconditioning protects hippocampal neurons from transient ischemia/reperfusion injury显示文摘The present study established a model of brain ischemia in aged rats using four-vessel occlusion.We observed hippocampal CA1 neuronal apoptosis and apoptosis-mediated protease caspase-3 expression following preconditioning of electroacupuncture at Baihui(GV 20).Our results showed that the number of hippocampal CA1 normal neurons was decreased,and degenerated neurons were increased 12 hours to 3 days following cerebral ischemia/reperfusion.The number of hippocampal CA1 apoptotic neurons and caspase-3-positive neurons in rats with cerebral ischemia/reperfusion injury was significantly decreased following acupuncture preconditioning.Acupuncture preconditioning protects aged rats against ischemia/reperfusion injury by regulating caspase-3 protein expression. | Mingshan Wang Haipeng Zhou Fei Shi Shilong Ma Yanlin Bi Yuqiu Liu Hong Liu Haiou Li | 2011 | Neural Regeneration Research2011，6，15： | 12 |
| 5 | Research on the conversion relationships between the river and groundwater in the Yellow River drainage area显示文摘Conversion relationships between the river and groundwater in the Yellow River drainage area are studied in this paper based on the geologic and physiognomy conditions and the data of the groundwater regime, isotope, groundwater flow field and field survey. Then eight recharge and discharge modes on the relationships are put forward and the hydraulic characteristics of the modes are analysed, which provides a scientific basis for quantitatively simulating and assessing the conversion relationships, maintenance mechanism of the Yellow River and the regeneration ability of the groundwater in the area. | WANG Wenke KONG Jinling DUAN Lei WANG Yanlin MA Xiongde | 2004 | Science China(Technological Sciences)2004，47，z1： | 5 |
| 6 | Abscisic acid receptors maintain abscisic acid homeostasis by modulating UGT71C5 glycosylation activity显示文摘Uridine diphosphate-glucosyltransferases(UGTs)maintain abscisic acid(ABA)homeostasis in Arabidopsis thaliana by converting ABA to abscisic acid-glucose ester(ABA-GE).UGT71C5 plays an important role in the generation of ABA-GE.Abscisic acid receptors are crucial upstream components of the ABA signaling pathway,but how UGTs and ABA receptors function together to modulate ABA levels is unknown.Here,we demonstrated that the ABA receptors RCAR12/13 and UGT71 C5 maintain ABA homeostasis in Arabidopsis following rehydration under drought stress.Biochemical analyses show that UGT71C5 directly interacted with RCAR8/12/13 in yeast cells,and the interactions between UGT-71C5 and RCAR12/13 were enhanced by ABA treatment.Enzyme activity analysis showed that ABA-GE contents were significantly elevated in the presence of RCAR12 or RCAR13,suggesting that these ABA receptors enhance the activity of UGT71C5.Determination of the content of ABA and ABA-GE in Arabidopsis following rehydration under drought stress revealed that ABA-GE contents were significantly higher in Arabidopsis plants overexpressing RCAR12 and RCAR13 than in nontransformed plants and plants overexpressing RCAR11 following rehydration under drought stress.These observations suggest that RCAR12 and RCAR13 enhance the activity of UGT71C5 to glycosylate excess ABA into ABA-GE following rehydration under drought stress,representing a rapid mechanism for regulating plant growth and development. | Yanlin Ma Jing Cao Qiaoqiao Chen Jiahan He Zhibin Liu Jianmei Wang Xufeng Li Yi Yang | 2021 | Journal of Integrative Plant Biology2021，63，3： | 3 |
| 7 | Strain heterogeneity,cooccurrence network,taxonomic composition and functional profile of the healthy ocular surface microbiome显示文摘Background:There is growing evidence indicating that the microbial communities that dwell on the human ocular surface are crucially important for ocular surface health and disease.Little is known about interspecies interactions,functional profiles,and strain heterogeneity across individuals in healthy ocular surface microbiomes.Methods:To comprehensively characterize the strain heterogeneity,cooccurrence network,taxonomic composition and functional profile of the healthy ocular surface microbiome,we performed shotgun metagenomics sequencing on ocular surface mucosal membrane swabs of 17 healthy volunteers.Results:The healthy ocular surface microbiome was classified into 12 phyla,70 genera,and 140 species.The number of species in each healthy ocular surface microbiome ranged from 6 to 47,indicating differences in microbial diversity among individuals.The species with high relative abundances and high positivity rates were Streptococcus pyogenes,Staphylococcus epidermidis,Propionibacterium acnes,Corynebacterium accolens,and Enhydrobacter aerosaccus.A correlation network analysis revealed a competitive interaction of Staphylococcus epidermidis with Streptococcus pyogenes in ocular surface microbial ecosystems.Staphylococcus epidermidis and Streptococcus pyogenes revealed phylogenetic diversity among different individuals.At the functional level,the pathways related to transcription were the most abundant.We also found that there were abundant lipid and amino acid metabolism pathways in the healthy ocular surface microbiome.Conclusion:This study explored the strain heterogeneity,cooccurrence network,taxonomic composition,and functional profile of the healthy ocular surface microbiome.These findings have important significance for the future development of probiotic-based eye therapeutic drugs. | Yutong Kang Shudan Lin Xueli Ma Yanlin Che Yiju Chen Tian Wan Die Zhang Jiao Shao Jie Xu Yi Xu Yongliang Lou Meiqin Zheng | 2021 | Eye and Vision2021，8，1： | 3 |
| 8 | A new gain-of-function OsGS2/GRF4 allele generated by CRISPR/Cas9 genome editing increases rice grain size and yield显示文摘Grain size is one of the most important factors affecting rice grain quality and yield,and attracts great attention from molecular biologists and breeders.In this study,we engineered a CRISPR/Cas9 system targeting the miR396 recognition site of the rice GS2 gene,which encodes growth-regulating factor 4(OsGRF4)and regulates multiple agronomic traits including grain size,grain quality,nitrogen use efficiency,abiotic stress response,and seed shattering.In contrast to most previous genome editing efforts in which indel mutations were chosen to obtain null mutants,a mutant named GS2^(E) carrying an in-frame 6-bp deletion and 1-bp substitution within the miR396-targeted sequence was identified.GS2^(E) plants showed increased expression of GS2 in consistent with impaired repression by miR396.As expected,the gain-of-function GS2^(E) mutant exhibited multiple beneficial traits including increased grain size and yield and bigger grain length/width ratio.Thousand grain weight and grain yield per plant of GS2^(E) plants were increased by 23.5%and 10.4%,respectively.These improved traits were passed to hybrids in a semidominant way,suggesting that the new GS2^(E) allele has great potential in rice improvement.Taken together,we report new GS2 germplasm and describe a novel gene-editing strategy that can be widely employed to improve grain size and yield in rice.This trait-improvement strategy could be applied to other genes containing miRNA target sites,in particular the conserved miR396-GRF/GIF module that governs plant growth,development and environmental response. | Wenshu Wang Weipeng Wang Yanlin Pan Chao Tan Hongjing Li Ya Chen Xingdan Liu Jing Wei Nian Xu Yu Han Han Gu Rongjian Ye Qi Ding Chonglie Ma | 2022 | The Crop Journal2022，10，4： | 3 |
| 9 | Recent Progress in Atmospheric Chemistry Research in China: Establishing a Theoretical Framework for the “Air Pollution Complex”显示文摘Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 on air pollution(only papers included in the Web of Science Core Collection database were considered),more than 24000 papers were authored or co-authored by scientists working in China.In this paper,we review a limited number of representative and significant studies on atmospheric chemistry in China in the last few years,including studies on(1)sources and emission inventories,(2)atmospheric chemical processes,(3)interactions of air pollution with meteorology,weather and climate,(4)interactions between the biosphere and atmosphere,and(5)data assimilation.The intention was not to provide a complete review of all progress made in the last few years,but rather to serve as a starting point for learning more about atmospheric chemistry research in China.The advances reviewed in this paper have enabled a theoretical framework for the air pollution complex to be established,provided robust scientific support to highly successful air pollution control policies in China,and created great opportunities in education,training,and career development for many graduate students and young scientists.This paper further highlights that developing and low-income countries that are heavily affected by air pollution can benefit from these research advances,whilst at the same time acknowledging that many challenges and opportunities still remain in atmospheric chemistry research in China,to hopefully be addressed over the next few decades. | Tong ZHU Mingjin TANG Meng GAO Xinhui BI Junji CAO Huizheng CHE Jianmin CHEN Aijun DING Pingqing FU Jian GAO Yang GAO Maofa GE Xinlei GE Zhiwei HAN Hong HE Ru-Jin HUANG Xin HUANG Hong LIAO Cheng LIU Huan LIU Jianguo LIU Shaw Chen LIU Keding LU Qingxin MA Wei NIE Min SHAO Yu SONG Yele SUN Xiao TANG Tao WANG Tijian WANG Weigang WANG Xuemei WANG Zifa WANG Yan YIN Qiang ZHANG Weijun ZHANG Yanlin ZHANG Yunhong ZHANG Yu ZHAO Mei ZHENG Bin ZHU Jiang ZHU | 2023 | Advances in Atmospheric Sciences2023，40，8： | 2 |
| 10 | Structures of the N- and C-terminal domains of MHV-A59 nucleocapsid protein corroborate a conserved RNA-protein binding mechanism in coronavirus显示文摘Coronaviruses are the causative agent of respiratory and enteric diseases in animals and humans.One example is SARS,which caused a worldwide health threat in 2003.In coronaviruses,the structural protein N(nucleocapsid protein)associates with the viral RNA to form the filamentous nucleocapsid and plays a crucial role in genome replication and transcription.The structure of Nterminal domain of MHV N protein also implicated its specific affinity with transcriptional regulatory sequence(TRS)RNA.Here we report the crystal structures of the two proteolytically resistant N-(NTD)and C-terminal(CTD)domains of the N protein from murine hepatitis virus(MHV).The structure of NTD in two different crystal forms was solved to 1.5Å.The higher resolution provides more detailed structural information than previous reports,showing that the NTD structure from MHV shares a similar overall and topology structure with that of SARS-CoV and IBV,but varies in its potential surface,which indicates a possible difference in RNA-binding module.The structure of CTD was solved to 2.0-Åresolution and revealed a tightly intertwined dimer.This is consistent with analytical ultracentrifugation experiments,suggesting a dimeric assembly of the N protein.The similarity between the structures of these two domains from SARS-CoV,IBV and MHV corroborates a conserved mechanism of nucleocapsid formation for coronaviruses. | Yanlin Ma Xiaohang Tong Xiaoling Xu Xuemei Li Zhiyong Lou Zihe Rao | 2010 | Protein & Cell2010，1，7： | 2 |
| 11 | Droplet Manipulation and Crystallization Regulation in Inkjet-Printed Perovskite Film Formation显示文摘Emerging organic–inorganic metal halide perovskite materials have become the focus of the optoelectronics research community owing to their excellent photoelectric properties.Nevertheless,challenges still exist for transferring the lab-made devices to largearea industrial modules.Inkjet printing(IJP)technology provides a promising way to fill the gap because of its precise droplet control and uniform large-scale deposition functions.Hence,an in-depth understanding of inkjet-printed perovskite films in terms of droplet manipulation and crystallization regulation is critical for upscaling the perovskite devices to commercial usage.In this review,we give an overview of inkjet-printed high-quality perovskite films and provide guidelines on inkjet-printing large-scale highperformance perovskite devices.First,we analyze theories of droplet formation and perovskite nucleation/crystallization dynamics and then focus on summarizing the perovskite film-formation strategies via IJP,in the aspects of ink engineering,the printing process,and posttreatment.Furthermore,we review the recent advances of inkjet-printed perovskite films on optoelectronic devices,such as perovskite solar cells,perovskite light-emitting diodes,and perovskite photodetectors.Finally,we highlight the“Trilogy Strategies,”including ink engineering,printing process,and posttreatment for printing high-quality perovskite films. | Yajie Cheng Hangjuan Wu Junjie Ma Pengwei Li Zhenkun Gu Shuangquan Zang Liyuan Han Yiqiang Zhang Yanlin Song | 2022 | CCS Chemistry2022，4，5： | 1 |
| 12 | Bioinspired molecules design for bilateral synergistic passivation in buried interfaces of planar perovskite solar cells显示文摘Trap-mediated energy loss in the buried interface with non-exposed feature constitutes one of the serious challenges for achieving high-performance perovskite solar cells(PSCs).Inspired by the adhesion mechanism of mussels,herein,three catechol derivatives with functional Lewis base groups,namely 3,4-Dihydroxyphenylalanine(DOPA),3,4-Dihydroxyphenethylamine(DA)and 3-(3,4-Dihydroxyphenyl)propionic acid(DPPA),were strategically designed.These molecules as interfacial linkers are incorporated into the buried interface between perovskite and SnO_(2) surface,achieving bilateral synergetic passivation effect.The crosslinking can produce secondary bonding with the undercoordinated Pb^(2+) and Sn^(4+) defects.The PSCs treated with DOPA exhibited the best performance and operational stability.Upon the DOPA passivation,a stabilized power conversion efficiency(PCE)of 21.5%was demonstrated for the planar PSCs.After 55 days of room-temperature storage,the unencapsulated devices with the DOPA crosslinker could still maintain 85%of their initial performance in air under relative humidity of-15%.This work opens up a new strategy for passivating the buried interfaces of perovskite photovoltaics and also provides important insights into designing defect passivation agents for other perovskite optoelectronic devices,such as light-emitting diodes,photodetectors,and lasers. | Bin Wang Junjie Ma Zehua Li Gangshu Chen Qiang Gu Shuyao Chen Yiqiang Zhang Yanlin Song Jingbo Chen Xiaodong Pi Xuegong Yu Deren Yang | 2022 | Nano Research2022，15，2： | 1 |
| 13 | Pol- len distribution in large {reshwater lake of arid region: A case study on the sur{ace sediments {tom Bosten Lake, Xinjiang, China 显示文摘 | HUANG Xiaozhong ZHOU Gang MA Yanlin | | Frontiers of Earth Science in China0，4，： | 1 |
| 14 | Conditional ablation of Ezh2 in murine hearts reveals Its essential roles in endocardial cushion formation,cardiomyocyte proliferation and survival显示文摘 | Li Chen Yanlin Ma Eun Young Kim | | 0，，02： | 1 |
| 15 | Thechanging face of HIV in China 显示文摘 | LIN LU MANHONG JIA YANLIN MA | 2008 | Nature2008，455，2： | 1 |
| 16 | Clinical value of serum Epstein-Barr virus DNA assay in the diagnosis of nasopharyngeal carcinoma显示文摘 | Dezhong Sun Zhaoke Yang Yugui Fu Yanlin Chen Shoufeng Wang Yun Zhang Yanyi Ma Xiaoyan Zhang | 2014 | Tumor Biology2014，，9： | 1 |
| 17 | Electrochemical performances of NiO/Ni2N nanocomposite thin film as anode material for lithium ion batteries显示文摘Despite the high specific capacities,the practical application of transition metal oxides as the lithium ion battery(LIB)anode is hindered by their low cycling stability,severe polarization,low initial coulombic efficiency,etc.Here,we report the synthesis of the NiO/Ni2N nanocomposite thin film by reactive magnetron sputtering with a Ni metal target in an atmosphere of 1 vol.% O2 and 99 vol.%N2.The existence of homogeneously dispersed nano Ni2N phase not only improves charge transfer kinetics,but also contributes to the one-off formation of a stable solid electrolyte interphase(SEI).In comparison with the NiO electrode,the NiO/Ni2N electrode exhibits significantly enhanced cycling stability with retention rate of 98.8%(85.6%for the NiO electrode)after 50 cycles,initial coulombic efficiency of 76.6%(65.0%for the NiO electrode)and rate capability with 515.3 mA·h·g^−1(340.1 mA·h·g^−1 for the NiO electrode)at 1.6 A·g^−1. | Yanlin JIA Zhiyuan MA Zhicheng LI Zhenli HE Junming SHAO Hong ZHANG | 2019 | Frontiers of Materials Science2019，13，4： | 1 |
| 18 | Structural regularized twin support vector machine based on within-class scatter and between-class scatter显示文摘Robust minimum class variance twin support vector machine(RMCV-TWSVM) presented previously gets better classification performance than the classical TWSVM. The RMCV-TWSVM introduces the class variance matrix of positive and negative samples into the construction of two hyperplanes. However, it does not consider the total structure information of all the samples, which can substantially reduce its classification accuracy. In this paper, a new algorithm named structural regularized TWSVM based on within-class scatter and between-class scatter(WSBS-STWSVM) is put forward. The WSBS-STWSVM can make full use of the total within-class distribution information and between-class structure information of all the samples. The experimental results illustrate high classification accuracy and strong generalization ability of the proposed algorithm. | Wu Qing Fu Yanlin Fan Jiulun Ma Tianlu | 2021 | The Journal of China Universities of Posts and Telecommunications2021，28，4： | 0 |
| 19 | Selective targeted adsorption and inactivation of antibiotic-resistant bacteria by Cr-loaded mixed metal oxides显示文摘Herein we provide a novel high-efficiency nanocomposite for bacterial capture based on mixed metal oxides(MMOs)with deleterious chromium properties.With both the layer structure of layered double hydroxides(LDHs)and the magnetic properties of Fe,MMOs enrich the location of ionic forms on the surface,providing a good carrier for adsorption of the heavy metal Cr(VI).The capacity for adsorption of Cr(VI)by MMOs can be as high as 98.80 mg/g.The prepared Cr(VI)-MMOs achieved extremely expeditious location of gram-negative antibiotic-resistant E.coliNDM-1 by identifying lipid bilayers.Cr-MMOs with a Cr loading of 19.70 mg/g had the best bactericidal effect,and the concentration of E.coliNDM-1 was decreased from~10^(8) to~10^(3) CFU/mL after 30 min of reaction.The binding of nitrogen and phosphorus hydrophilic groups to chromate generated realistic models for density functional theory(DFT)calculations.The specific selectivity of MMOs toward bacterial cells was improved by taking Cr(VI)as a transferable medium,thereby enhancing the antibacterial activity of Cr-MMOs.Under the combined action of chemical and physical reactions,Cr(VI)-MMOs achieved high capacity for inactivation of bacteria.Moreover,the metallic elements ratio in Cr-MMOs remained stable in their initial valence states after inactivation.This guaranteed high removal efficiency for both heavy metals and bacteria,allowing recycling of the adsorbent in practical applications. | Yanlin Li Bo Wang Lei Zhu Yixing Yuan Lujun Chen Jun Ma | 2022 | Frontiers of Environmental Science & Engineering2022，16，6： | 0 |
| 20 | Application of next-generation sequencing in thalassemia screening:A systematic review and meta-analysis显示文摘Objective:To evaluate the value of next-generation sequencing(NGS)in the prevention and management of thalassemia.Methods:A systematic search was performed in eight databases including China Biomedical Literature Database,Chinese National Knowledge Infrastructure,Chinese Scientific Journals Database,Wanfang database,PubMed,EMBASE,Web of Science,and Cochrane Library from the inception to 1 June 2022.Stata 17.0 and Review Manager 5.4 were used for the meta-analysis.Results:Nine studies containing 14794 participants were included in the meta-analysis.Compared with the routine genetic testing(including Gap-PCR and reverse dot blot),NGS had higher detection rates in screening thalassemia(RR 1.22,95%CI 1.13-1.31,P<0.01),particularly for theα-thalassaemia mutation carriers(RR 1.24,95%CI 1.07-1.44,P<0.01).However,no significant difference was found in the screening ofβ-thalassemia(RR 1.10,95%CI 0.99-1.23,P>0.05).Conclusions:Compared with routine genetic testing,NGS had a higher detection rate in general,particularly in the detection ofα-thalassemia. | Xingyi Fang Yi Gong Yanlin Ma Yuanhua Huang | 2023 | Asian Pacific Journal of Tropical Medicine2023，16，2： | 0 |
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