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| 1 | In vivo and in vitro effects of QHF combined with chemotherapy on hepatocellular carcinoma显示文摘Objective:To investigate the synergistic anti-tumor effect of QHF (a Chinese medicine formula with antitumor active ingredients, including 800 mg/kg Cinobufotalin, 14 mg/kg Ginsenoside Rg3, 5.5 mg/kg Notoginseng and 100 mg/kg Lentinan) when combined with the chemotherapy drug cisplatin (DDP). Methods: Hepatocellular carcinoma H22 cells were implanted into mice and after the transplants were successfully established the animals were divided into four groups, namely a normal saline(NS) control group, QHF group, DDP group and QHF+DDP group. The tumor growth was monitored and the survival time determined. In vitro studies employing H22 cells used the first three groups, and determined the effects of QHF and DDP on tumor cell cycle distribution, apoptosis and morphologic changes in vitro. Results: QHF significantly inhibited the growth of tumors and prolonged the survival time of mice with hepatocellular carcinomas. QHF combined with DDP could attenuate DDP-induced leucopenia, spleen and thymus atrophy and other indicators of toxicity. The inhibition rate of tumor growth reached 82.54% with QHF+DDP, and QHF prolonged the life span of DDP-treated mice by 66.83%. In the in vitro experiments tumor cells showed morphological changes characteristic of apoptosis by both light and transmission electron microscopy in the QHF group, and the apoptosis rate was 33.85%. Moreover, the proportion of cells in the G0/G1 phase was increased and those in the S-phase decreased. Conclusion: QHF combined with DDP could significantly inhibit tumor growth, induce the apoptosis of tumor cells and effectively attenuate DDP toxicity. | Chen Tao Li Dan Fuya ling Gongzi Peng | 2010 | The Journal of Biomedical Research2010，24，2： | 9 |
| 2 | DeterminationofP-GlucontentinsolidsubstanceofTanreqinginjectionbyRP-HPLC(痰热清注射液固形物中焦谷氨酸组分的RP-HPLC法测定)显示文摘 | YANGQing-lin(杨清林) FUYa(傅亚) | | JChongqingNormUniv(NatSci)0，，： | 1 |
| 3 | Quantifying out-of-station waiting time in oversaturated urban metro systems显示文摘Metro systems in megacities such as Beijing,Shenzhen,and Guangzhou are under great passenger demand pressure.During peak hours,it is common to see oversaturated conditions(i.e.,passenger demand exceeds network capacity)and a popular control intervention is to restrict the entering rate by setting up out-of-station queueing with crowd control barriers.The out-of-station waiting can make up a substantial proportion of total travel time but is often ignored in the literature.Quantifying out-of-station waiting is important to evaluating the social benefit and cost of metro services;however,out-of-station waiting is difficult to estimate because it leaves no trace in smart card transactions of metros.In this study,we estimate the out-of-station waiting time by leveraging the information from a small group of transfer passengers—those who transfer from nearby bus routes to the metro station.Based on the transfer interval of this small group,we infer the out-of-station waiting time for all passengers by a Gaussian Process regression and then use the estimated out-of-station waiting time to build queueing diagrams.We apply our method to the Tiantongyuan North station of Beijing metro;results show that the maximum out-of-station waiting time can reach 15 min,and the maximum queue length can be over 3000 passengers.We find out-of-station waiting can cause significant travel costs and thus should be considered in analyzing transit performance,mode choice,and social benefits.To the best of our knowledge,this paper is the first quantitative study for out-of-station waiting time. | Kangli Zhu Zhanhong Cheng Jianjun Wu Fuya Yuan Lijun Sun | 2022 | Communications in Transportation Research2022，2，1： | 1 |
| 4 | Cova- lent cross linked polymer gels with reversible Sol-Gel transition and self-healing properties 显示文摘 | Deng Guohua Tang Chuanmei Li Fuya | 2010 | Macromole- cules2010，43，3： | 1 |
| 5 | PreparationandcyGtocompaibilitystudyonelectrospunpoly (D,L,lacticacid)fibrousscaffolds显示文摘 | FuYa HuChengbo XuJing etal | 2012 | JournalofFunctionalMateriGals2012，18，43： | 1 |
| 6 | PrepartionofgraGpheneoxideGnial/layereddoublehydroxideGcarbonfiberscompositematerialandelectrosorption2,6Gdichlorophenolinaqueoussolution显示文摘 | WuJiaan BaoXingchen FuYa etal | 2013 | JournalofFunctionalMaterials2013，20，5： | 1 |
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