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| 1 | Calreticulin and cancer显示文摘Calreticulin(CALR)is an endoplasmic reticulum(ER)-resident protein involved in a spectrum of cellular processes.In healthy cells,CALR operates as a chaperone and Ca^(2+)buffer to assist correct protein folding within the ER.Besides favoring the maintenance of cellular proteostasis,these cell-iintrinsic CALR functions support Ca^(2+)-dependent processes,such as adhesion and integrin signaling,and ensure normal antigen presentation on MHC Class I molecules.Moreover,cancer cells succumbing to immunogenic cell death(ICD)expose CALR on their surface,which promotes the uptake of cell corpses by professional phagocytes and ultimately supports the initiation of anticancer immunity.Thus,loss-of-function CALR mutations promote oncogenesis not only as they impair cellular homeostasis in healthy cells,but also as they compromise natural and therapy-driven immunosurveillanee.However,the prognostic impact of total or membrane-exposed CALR levels appears to vary considerably with cancer type.For instance,while genetic CALR defects promote pre-neoplastic myeloproliferation,patients with myeloproliferative neoplasms bearing CALR mutations often experience improved overall survival as compared to patients bearing wild-type CALR.Here,we discuss the context-dependent impact of CALR on malignant transformation,tumor progression and response to cancer therapy. | Jitka Fucikova Radek Spisek Guido Kroemerc Lorenzo Galluzzi | 2021 | Cell Research2021，31，1： | 12 |
| 2 | Laparoscopy in chronic Pelvicpain-a retrospective cllnical study显示文摘 | Mara M Fucikova Z kuzel D | | Ceska Gynekol0，67，1： | 1 |
| 3 | The antiphospholipid syndrome and antiphospholipid antibodies显示文摘 | Malickova K Fucikova T | 2001 | Cas Lek Cesk2001，140，15： | 1 |
| 4 | Human tumor cells killed by anthracyclines induce a tumor-specific immune response显示文摘 | Fucikova J Kralikova P Fialova A | | 0，，14： | 1 |
| 5 | Hysteroscopic resection of submu- cosal myoma in abnormal uterine bleeding: results of a 4 year prospec- tive study 显示文摘 | Kuxel D Toth D Fucikova Z | 1999 | Ceska Gynekol1999，64，6： | 1 |
| 6 | Laparoscopyinchronic-pelVic pain-aretrospeclinicalstudy显示文摘 | Mara M Fucikova Z Kuzel D | 2002 | Ceska Gynekol2002，67，1： | 1 |
| 7 | Laparoscopy in chronic pelvicpain-a retrospective clinical study显示文摘 | Mara M Fucikova z kuzel D | 2002 | Ceska Gynekol2002，67，1： | 1 |
| 8 | Inhibitor of ap- optosis protein antagonists demonstrate divergent immunomodulato- ry properties in human immune subsets with implications for com- bination therapy 显示文摘 | KNIGHTS A J FUCIKOVA J PASAM A | 2013 | Cancer Immunol Immunother2013，62，2： | 1 |
| 9 | Laparoscopy in chronic Pelvicpain-a retrospective clinical study显示文摘 | Mara M Fucikova Z kuzel D | 2012 | Ceska Gynekol2012，67，1： | 1 |
| 10 | Midterm clinical and first reproductive results of a randomized controlled trial comparing uterine fibroid embolization and myomectomy显示文摘 | Mara M Maskova J Fucikova Z | 2008 | Cardiovasc Intervent Radiol2008，31，1： | 1 |
| 11 | Influence of cadmium and zinc sulphates on the function of human T lymphocytes in vitro显示文摘 | Petanova J Fucikova T Bencko V | 2000 | Cent Eur J Public Health2000，8，3： | 1 |
| 12 | Human tumor cells killed by anthraeyelines induce a tumor-specific im- mune response 显示文摘 | Fucikova J Kralikova P Fialova A | 2011 | Cancer Res2011，71，： | 1 |
| 13 | Laparoscopy in chronic pelvic pain--a retrospective clinical study 显示文摘 | Mara M Fucikova Z Kuzel D | 2002 | Ceska Gynekol2002，67，： | 1 |
| 14 | Uterine fibroid embolization versus myomectomy in women wishing to preserve fertility: preliminary results of a randomized controlled trial显示文摘 | Mara M Fucikova Z Maskova J | 2006 | Eur ] Obstet Gynecol Reprod Biol2006，126，2： | 1 |
| 15 | Midterm clinical and first reproductive results of a randomized controlled trial comparing uterine fibroid embolization and myomectomy显示文摘 | Mara M Maskova J Fucikova Z | 2008 | Cardiovasc Intervent Radio/2008，31，1： | 1 |
| 16 | Laparocopy in chronic Pelvicpain - a retrospective clinical study 显示文摘 | Mara M Fucikova Z kuzel D | 2002 | Ceska Gynekol2002，67，1： | 1 |
| 17 | FOCUS on FOCIS:Combined chemo-immunotherapy for the treatment of hormone-refractory metastatic prostate cancer显示文摘 | Rozkova D Tiserova H Fucikova J | 2009 | Clin Immunol2009，131，： | 1 |
| 18 | Human tumor cells killed by anthracyclines induce a tumor-specific immune response显示文摘 | Fucikova J Kralikova P Fialova A | 2011 | Cancer Res2011，71，14： | 1 |
| 19 | Laparoscopy in chronic Pelvicpain-a retrospective clinical study 显示文摘 | Mara M Fucikova Z kuzel D | 2002 | Ceska Gynekol2002，67，1： | 1 |
| 20 | Midterm clinical and first reproductive resuks of a randomized controlled trial comparing uterine fibroid embolization and myomectomy 显示文摘 | Mara M Maskova J Fucikova Z | 2008 | Cardiovasc Intervent Radiol2008，31，15： | 1 |
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