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| 1 | Inflammatory responses in hypoxic ischemic encephalopathy显示文摘 | Fudong Liu Louise D McCullough | 2013 | Acta Pharmacologica Sinica2013，34，9： | 45 |
| 2 | Regulation of microglial activation in stroke显示文摘当 ischemic 击发生时,氧和精力弄空触发事件的串联,包括导致深刻大脑损害的煽动性的回答, glutamate excitotoxicity,氧化压力,和 apoptosis。煽动性的反应贡献第二等的 neuronal 损坏,它在两尖锐 ischemic 损害和大脑功能的长期的恢复上施加实质的影响。Microglia 是在常常,在正常下面的监视器大脑微型环境调节的大脑的居民免疫者房间。一旦局部缺血发生, microglia 被激活生产有害并且二个抵抗调停人的 neuroprotective 调停人,和平衡决定受伤神经原的命运。microglia 的激活被定义为经典著作(M1 ) 或选择(M2 ) :M1 microglia 分泌支持 inflammatory cytokines (TNF, IL-23, IL-1, IL-12,等等) 并且加重 neuronal 损害,而 M2 显型支持反煽动性的回答,那是修理的。它有重要翻译价值调整 M1/M2 microglial 激活最小化有害效果或最大化保护的角色。这里,我们在 ischemic 击的上下文讨论在 microglia 和神经原之间的 microglia/macrophage 激活和相互作用的各种各样的管理者。 | Shou-cai ZHAO Ling-song MA Zhao-hu CHU Heng XU Wen-qian WU Fudong LIU | 2017 | Acta Pharmacologica Sinica2017，38，4： | 38 |
| 3 | Hydroxysafflor yellow A improves learning and memory in a rat model of vascular dementia by increasing VEGF and NR1 in the hippocampus显示文摘Hydroxysafflor yellow A(HSYA) has angiogenesisregulating and neuro-protective effects, but its effects on vascular dementia(VaD) are unknown. In this study, 30 adult Sprague-Dawley rats were randomly allocated to five groups: normal, sham-operation, VaD alone(bilateral carotid artery occlusion), VaD plus saline(control), and VaD plus HSYA. One week after operation, the HSYA group received one daily tail-vein injection of 0.6 mg/100 g HSYA for two weeks. Five weeks after operation, the spatial memory of all five groups was evaluated by the water maze task, and synaptic plasticity in the hippocampus was assessed by the long-term potentiation(LTP) method. Vascular endothelial growth factor(VEGF) and N-methyl-Daspartic acid receptor 1(NR1) expression in the hippocampus was detected via Western blot. We found that, compared with the group with VaD alone, the group with HSYA had a reduced escape latency in the water maze(P <0.05), and the LTP at CA3-CA1 synapses in the hippocampus was enhanced(P <0.05). Western blot in the late-phase VaD group showed slight up-regulation of VEGF and downregulation of NR1 in the hippocampus, while HSYA significantly up-regulated both VEGF and NR1. Theseresults suggested that HSYA promotes angiogenesis and increases synaptic plasticity, thus improving spatial learning and memory in the rat model of VaD. | Nan Zhang Mengya Xing Yiyi Wang Hao Liang Zhuo Yang Fudong Shi Yan Cheng | 2014 | Neuroscience Bulletin2014，30，3： | 30 |
| 4 | Major Technologies for Safe Construction of High Earth-Rockfill Dams显示文摘 | Hongqi Ma Fudong Chi | 2016 | Engineering2016，2，4： | 22 |
| 5 | Structural insights of phosphorylated into the recognition FUNDC1 by LC3B in mitophagy显示文摘 | Mengqi Lv Chongyuan Wang Fudong Li Junhui Peng Bin Wen Qingguo Gong Yunyu Shi Yajun-Tang | 2017 | Protein & Cell2017，8，1： | 21 |
| 6 | Technical Progress on Researches for the Safety of High Concrete-Faced Rockfill Dams显示文摘The concrete-faced rockfill dam(CFRD) is an important dam type in the selection of high dams to be constructed in Western China,owing to its direct utilization of local materials,good adaptability,and distinct economic advantages.Over the past decades,China has gained successful experience in the construction of 200 m CFRDs,providing the necessary technical accumulation for the development of 250–300 m ultra-high CFRDs.This paper summarizes these successful experiences and analyzes the problems of a number of major 200 m CFRDs around the world.In addition,it discusses the key technologies and latest research progress regarding safety in the construction of 250–300 m ultra-high CFRDs,and suggests focuses and general ideas for future research. | Hongqi Ma Fudong Chi | 2016 | Engineering2016，2，3： | 19 |
| 7 | Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition显示文摘 | Fudong Li Debiao Zhao Jihui Wu Yunyu Shi | 2014 | Cell Research2014，24，12： | 16 |
| 8 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 9 | Delay-dependent stability and added damping of SDOF real-time dynamic hybrid testing显示文摘It is well-recognized that a transfer system response delay that reduces the test stability inevitably exists in real-time dynamic hybrid testing (RTDHT).This paper focuses on the delay-dependent stability and added damping of SDOF systems in RTDHT.The exponential delay term is transferred into a rational fraction by the Padé approximation, and the delay-dependent stability conditions and instability mechanism of SDOF RTDHT systems are investigated by the root locus technique.First, the stability conditions are discussed separately for the cases of stiffness, mass, and damping experimental substructure.The use of root locus plots shows that the added damping effect and instability mechanism for mass are different from those for stiffness.For the stiffness experimental substructure case, the instability results from the inherent mode because of an obvious negative damping effect of the delay.For the mass case, the delay introduces an equivalent positive damping into the inherent mode, and instability occurs at an added high frequency mode.Then, the compound stability condition is investigated for a general case and the results show that the mass ratio may have both upper and lower limits to remain stable.Finally, a high-emulational virtual shaking table model is built to validate the stability conclusions. | Chi Fudong Wang Jinting Jin Feng | 2010 | Earthquake Engineering and Engineering Vibration2010，9，3： | 13 |
| 10 | Design and Mechanical Performance Analysis of a New Wheel Propeller显示文摘Nowadays,how to enhance the maneuverability of autonomous underwater vehicles(AUVs) is an important issue in the domain of international navigation in that most AUVs just have a single function of underwater navigation or submarine movement,while the design of thrusters is the key of solving the problem.The multi-moving state autonomous underwater vehicle in this paper can achieve four functions,such as wheels,legs,thrust,and course control depend on the characteristics of spatial deflexion and continual circumgyratetion of the flexible transmission shaft.A new wheel propeller for the multi-moving state autonomous underwater vehicle is presented through analyzing the mechanical characteristics of the ducted propeller and the contracted and loaded tip(CLT) propeller.Then the computational fluid dynamics(CFD) method is used to simulate numerically different propellers open-water performance by using the Reynolds-averaged Navier-Stokes(RANS) equations and Reynolds stress model(RSM) based on sub-domains hybrid meshes.The predicted thrust coefficients,torque coefficients and pressure of the propellers agree well with the experimental data of their open-water performance.The good consistency shows that the numerical method has good accuracy in the prediction of propeller open-water performance,which guides to design the wheel propeller.Moreover,for the sake of ensuring the security and stability of the AUV when it is moving on the ground,finite element method is used to simulate numerically the intensity and vibration characteristics.The proposed final wheel propeller D4-70(WPD4-70) has preferable open-water performance and intensity characteristics,which can realize the agile maneuverability of the multi-moving state autonomous underwater vehicle. | GAO Fudong PAN Cunyun XU Haijun ZUO Xiaobo | 2011 | Chinese Journal of Mechanical Engineering2011，24，5： | 8 |
| 11 | Effect of preparation methods on the performance of CuFe-SSZ-13 catalysts for selective catalytic reduction of NO_x with NH_3显示文摘CuFe-SSZ-13 catalyst showed excellent performance in the selective catalytic reduction of NO_x with NH_3(NH_3-SCR) for diesel engine exhaust purification. To investigate the effect of preparation methods on NH_3-SCR performance, Fe was loaded into one-pot synthesized Cu-SSZ-13 catalysts through solid-state ion-exchange(SSIE), homogeneous deposition precipitation(HDP) and liquid ion-exchange(IE), respectively. Three CuFe-SSZ-13 catalysts showed similar SO_2 resistance, which was better than that of Cu-SSZ-13. The improvement was attributed to the protection of Fe species. Hydrothermal stability of three CuFe-SSZ-13 catalysts was significantly different, which was attributed to the state of active species caused by different preparation methods. Compared with the other two catalysts, more active species existed inside the zeolite pores of CuFe-SSZ-13 SSIE. During hydrothermal aging, the aggregation of these active species in the pores caused the collapse of catalyst structure, ultimately leading to the deactivation of CuFe-SSZ-13 SSIE. In contrast, Fe species was dispersed better on the surface over CuFe-SSZ-13 IE, enhancing the hydrothermal stability of catalysts. Consequently, Fe loading effectively improved the resistance of SO_2 and H_2O over Cu-SSZ-13. For CuFe-SSZ-13, large amounts of active species located inside the zeolite pores are not beneficial for the hydrothermal stability. | Yijiao Wang Lijuan Xie Fudong Liu Wenquan Ruan | 2019 | Journal of Environmental Sciences2019，31，7： | 8 |
| 12 | Analysis of stability of support and surrounding rock in mining top coal of inclined coal seam显示文摘The study analyzes the characteristics of roof movement in mining top coal of inclined coal seam,and establishes the mechanical model of support and surrounding-rock stability in inclined coal seam.Besides,this study carries out the numerical calculation and field observation of roof movement and support stability,and provides the critical control measures.The results show that the fracture firstly appears in middle-upper roof and extends upwards in top coal caving in inclined coal seam;regular and irregular caving zones appear in middle-upper stress concentration region,and the asymmetric caving arch is finally formed.Support load of middle-upper working face is larger than that of the middle-lower face;dynamic load coefficient of upper support is large,and the load on the front of support is larger than that on the rear of it,which leads to poor support stability.Stability of support and surrounding-rock system depends mainly on upper-support stability. | Xin Yajun Gou Panfeng Ge Fudong | 2014 | International Journal of Mining Science and Technology2014，24，1： | 8 |
| 13 | Madouzi-type (nodular) sedimentary copper deposit associated with the Emeishan basalt显示文摘Ore minerals in the sedimentary-type Cu deposits in the Xuanwei Formation overlying the Emeishan basalt are dominated by copper sulfides and native copper. As the ores mostly exhibit concretionary structure, previous researchers named them the 'Madouzi-type Copper Deposit'. Here the authors carried out mineralogical and isotopic studies on copper nodules in this ore deposit. The mineralogical study shows that copper nodules are composed of copper sulfides that have been cemented by ferruginous amorphous minerals, clay, and carbonaceous fragments in the modes of metasomatism and sedimentation. The nodules are preliminarily present as aggregates of gelatinous material. The isotopic analysis shows that the δ 13CPDB values of an- thraxolite are within the range of-24.8‰--23.9‰, indicating that the anthraxolite is the product of sedimentary metamorphism of in-situ plants. The δ 34SV-CDT values of chalcocite are within the range of 7.6‰-13.1‰, close to those (about 11‰) of Permian seawater. The δ 34SV-CDT values of bornite and chalcopyrite are 21.6‰-22.2‰, similar to the sulfur isotopic composition (20‰) of marine sulfate, indicative of different sources of sulfur. The above characteristics indicate that the copper nodules were formed in such a process that Cu-bearing basalt underwent weathering-leaching and copper-bearing material was transported into waters (e.g., rivers, lakes, and swamps) and then adsorbed on clay and ferruginous amorphous mineral fragments. Then, the copper-bearing material was suspended and transported in the form of gelinite. In lake or swamp environment, it was co-deposited with sediments to form copper nodules. At later stages there occurred metasomatism and hydrothermal su- perimposition, followed by the replacement of chalcocite by bornite and the superimposition of chalcopyrite over bornite, finally resulting in the formation of the 'Madouzi-type' nodular copper deposit. | WANG FuDong ZHU XiaoQing WANG ZhongGang | 2011 | Science China Earth Sciences2011，54，12： | 7 |
| 14 | Modeling experimental study on weathering-leaching of Emeishan basalt and its relation with metallogenesis显示文摘The Emeishan basalt has a high Cu background value (170×10-6 on average), and thus provides a ore-forming material source for copper ores. The collected samples were exposed in basalt lavas of the third segment of the Emeishan basalt eruptive cycle. By using a set of automatically cycling glass apparatuses, weathering-leaching experiments by three kinds of rainwater on the collected samples were carried out in the open system (at normal temperature and normal pressure). The analysis results showed that the most intensive export of Cu occurred under acidic rainwater-induced weathering-leaching conditions, almost 2-3 orders of magnitude the export of Cu by mod-ern air rainwater, and 1-2 orders of magnitude higher than the export of Cu by CO2 rainwater. In addition, the total amount of Zn, Cu, U, Ni and Sr exported by acidic rainwater are greater than 1%. All this indicates that copper in the Emeishan basalt provided the copper source for Cu mineralization at the contact between the basalt and the Maokou Formation limestone at the bottom. | WANG Fudong ZHU Xiaoqing HAN Tao LI Zengsheng | 2010 | Chinese Journal Of Geochemistry2010，29，2： | 6 |
| 15 | Live cell single molecule-guided Bayesian localization super resolution microscopy显示文摘 | Xu, Fan Zhang, Mingshu He, Wenting Han, Renmin Xue, Fudong Liu, Zhiyong Zhang, Fa Lippincott-Schwartz, Jennifer Xu, Pingyong | 2017 | Cell Research2017，27，5： | 6 |
| 16 | Design and Analysis of a New AUV's Sliding Control System Based on Dynamic Boundary Layer显示文摘The new AUV driven by multi-vectored thrusters not only has unique kinematic characteristics during the actual cruise but also exists uncertain factors such as hydrodynamic coefficients perturbation and unknown interference of tail fluid,which bring difficult to the stability of the AUV's control system.In order to solve the nonlinear term and unmodeled dynamics existing in the new AUV's attitude control and the disturbances caused by the external marine environment,a second-order sliding mode controller with double-loop structure that considering the dynamic characteristics of the rudder actuators is designed,which improves the robustness of the system and avoids the control failure caused by the problem that the design theory of the sliding mode controller does not match with the actual application conditions.In order to avoid the loss of the sliding mode caused by the amplitude and rate constraints of the rudder actuator in the new AUV's attitude control,the dynamic boundary layer method is used to adjust the sliding boundary layer thickness so as to obtain the best anti-chattering effects.Then the impacts of system parameters,rudder actuator's constraints and boundary layer on the sliding mode controller are computed and analyzed to verify the effectiveness and robustness of the sliding mode controller based on dynamic boundary layer.The computational results show that the original divergent second-order sliding mode controller can still effectively implement the AUV's attitude control through dynamically adjusting the sliding boundary layer thickness.The dynamic boundary layer method ensures the stability of the system and does not exceed the amplitude constraint of the rudder actuator,which provides a theoretical guidance and technical support for the control system design of the new AUV in real complex sea conditions. | GAO Fudong PAN Cunyun HAN Yanyan | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 5 |
| 17 | Parallel architecture and optimization for discrete-event simulation of spike neural networks显示文摘Spike neural networks are inspired by animal brains,and outperform traditional neural networks on complicated tasks.However,spike neural networks are usually used on a large scale,and they cannot be computed on commercial,off-the-shelf computers.A parallel architecture is proposed and developed for discrete-event simulations of spike neural networks.Furthermore,mechanisms for both parallelism degree estimation and dynamic load balance are emphasized with theoretical and computational analysis.Simulation results show the effectiveness of the proposed parallelized spike neural network system and its corresponding support components. | TANG YuHua ZHANG BaiDa WU JunJie HU TianJiang ZHOU Jing LIU FuDong | 2013 | Science China(Technological Sciences)2013，56，2： | 5 |
| 18 | Age-related differences in interferon regulatory factor-4 and -5 signaling in ischemic brains of mice显示文摘 | Shou-cai ZHAO Chun WANG Heng XU Wen-qian WU Zhao-hu CHU Ling-song MA Ying-dong ZHANG Fudong LIU | 2017 | Acta Pharmacologica Sinica2017，38，11： | 4 |
| 19 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 20 | Effectiveness and safety of Shenmai injection in treatment of shock:a Meta-analysis显示文摘OBJECTIVE:To evaluate the effectiveness and safety of Shenmai injection for shock.METHODS: Randomized controlled trials(RCTs)that evaluated the therapeutic effect of Shenmai injection on shock(including septic shock, cardiogenic shock, hypovolemic shock, neurogenic shock and anaphylactic shock) were included in this analysis. The major electronic databases were searched until May 2015. The methodological quality of the trials was assessed according to the Cochrane Handbook. Review Manager 5.3 and Stata 12.0 software were applied for data analysis.RESULTS: Thirty RCTs involving 2038 participants were included. The methodological quality of the trials was generally passable. The combined use of Shenmai injection and conventional medicine was significantly more effective at managing shock compared to conventional medicine alone in the outcomes of total effective rate [risk ratio(RR 1.25,95% confidence interval(CI) 1.18 to 1.31] and mortality rate [risk difference(RD)-0.10, 95% CI-0.17 to-0.02]. Likewise, improvements were observed in other metrics. Three trials reported adverse events, but no trial reported serious adverse effects.CONCLUSION: Our results indicated the potential effectiveness of Shenmai injection combined with conventional medicine treatment for shock. However, further rigorously designed trials are needed to collect and weigh up all the evidence for the use of Shenmai injection. | Li Xiaoli Shen Yi He Fan Zhu Yinchao Li Fudong | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 4 |
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