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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 3 | Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury显示文摘AIM To investigate the hepatic microcirculatory changes due to Haemoxygenase(HO),effect of HO inhibition on remote ischemic preconditioning(RIPC) and modulation of CINC.METHODS Eight groups of animals were studied- Sham,ischemia reperfusion injury(IRI) the animals were subjected to 45 min of hepatic ischemia followed by three hours of reperfusion,RIPC(remote ischemic preconditioning) + IRI group,remote ischemic preconditioning in sham(RIPC + Sham),PDTC + IR(Pyridodithiocarbamate,HO donor),Zn PP + RIPC + IRI(Zinc protoporphyrin prior to preconditioning),IR-24(45 min of ischemia followed by 24 h of reperfusion),RIPC+IR-24(preconditioning prior to. After 3 and 24 h of reperfusion the animals were killed by exsanguination and samples were taken. RESULTS Velocity of flow(160.83 ± 12.24 μm/s),sinusoidal flow(8.42 ± 1.19) and sinusoidal perfusion index(42.12 ± 7.28) in hepatic IR were lower(P < 0.05) in comparison to RIPC and PDTC(HO inducer). RIPC increased velocity of flow(328.04 ± 19.13 μm/s),sinusoidal flow(17.75 ± 2.59) and the sinusoidal perfusion index(67.28 ± 1.82)(P < 0.05). PDTC(HO induction) reproduced the effects of RIPC in hepatic IR. PDTC restored RBC velocity(300.88 ± 22.109 μm/s),sinusoidal flow(17.66 ± 3.71) and sinusoidal perfusion(82.33 ± 3.5) to near sham levels. Zn PP(HO inhibition) reduced velocity of flow of RBC in the RIPC group(170.74 ± 13.43 μm/s and sinusoidal flow in the RIPC group(9.46 ± 1.34). Zn PP in RIPC(60.29 ± 1.82) showed a fall in perfusion only at 180 min of reperfusion. Neutrophil adhesion in IR injury is seen in both postsinusoidal venules(769.05 ± 87.48) and sinusoids(97.4 ± 7.49). Neutrophil adhesion in RIPC + IR injury is reduced in both postsinusoidal venules(219.66 ± 93.79) and sinusoids(25.69 ± 9.08)(P < 0.05). PDTC reduced neutrophil adhesion in both postsinusoidal venules(89.58 ± 58.32) and sinusoids(17.98 ± 11.01)(P < 0.05) reproducing the effects of RIPC. Zn PP(HO inhibition) increased venular(589.04 ± 144.36) and sinusoidal neutrophil adhesion in preconditioned animals(121.39 ± 30.65)(P < 0.05). IR after 24 h of reperfusion increased venular and sinusoidal neutrophil adhesion in comparison to the early phase and was significantly reduced by RIPC. Hepatocellular cell death in IRI(80.83 ± 13.03),RIPC + IR(17.35 ± 2.47),and PTDC+IR(11.66 ± 1.17) Zn PP + RIPC + IR(41.33 ± 3.07) reduced hepatocellular death. Zn PP significantly increased hepatocellular death(P < 0.05 PTDC/RIPC vs Zn PP and IR). The CINC cytokine levels in sham(101.32 ± 6.42). RIPC + sham(412.18 ± 65.24) as compared to sham(P < 0.05). Hepatic IR(644.08 ± 181.24)(P < 0.05). RIPC CINC-1 levels in the early phase(401.62 ± 78.56). And PDTC(HO inducer) CINC-1 levels in hepatic IR(413.36 ± 63.06) were significantly lower. HO inhibition in preconditioned animals with Zinc protoporphyrin increased serum CINC levels(521.81 ± 74.9)(P < 0.05). The serum CINC levels were high in the late phase of hepatic IR(15306 ± 1222.04). RIPC reduced CINC levels in the late phase of IR(467.46 ± 26.06),P < 0.05.CONCLUSION RIPC protects hepatic microcirculation by induction of HO and modulation of CINC in hepatic IR. | Niteen Tapuria Sameer Junnarkar Mahmoud Abu-amara Barry Fuller Alexander M Seifalian Brian R Davidson | 2016 | World Journal of Gastroenterology2016，22，33： | 3 |
| 4 | FTIR spectroscopic analysis of coals and coal extracts显示文摘 | COOKE N E FULLER M O GAIKWARD R P | 1986 | Fuel1986，65，9： | 2 |
| 5 | Chemical characterization of tribochemical and thermal films generated from neutral and basic ZDDPs using X - Ray Absorption Spectroscopy 显示文摘 | Fuller M Yin Z F Kasrai M | 1997 | Tribology International1997，30，4： | 1 |
| 6 | The Characterisation and Measurement of Land Cover Change Through Remote Sensing: Problems in Operational Applications显示文摘 | Fuller R M Smith G M Devereux B J | 2003 | International Journal of Applied Earth Observation and Geoinformation2003，4，： | 1 |
| 7 | Control of mitochondrial morphology by a human mitofusin显示文摘 | SANTEL A FULLER M T | 2001 | J Cell Sci2001，114，5： | 1 |
| 8 | Magnetic material in the human hippocampus显示文摘 | Dunn JR Fuller M Zoeger J | 1995 | Brain Res Bull1995，36，2： | 1 |
| 9 | An error analysis of failure prediction techniques derived from fracture mechanics 显示文摘 | Wiederhom S M Fuller E R Mandel J | 1976 | Journal of the American Ceramic Society1976，59，910： | 1 |
| 10 | Hysteresis properties of titaimagnetities: Grain-size and compositional dependence 显示文摘 | Day R Fuller M Schmidt V A | 1977 | Physics of the Earth and Planetary Interiors1977，13，4： | 1 |
| 11 | Mechanisms of tribochemical film formation : stability of tribo - and thermally - generated ZDDP films显示文摘 | Bancroft G M Kasrai M Fuller M | 1997 | Tribology Letters1997，3，1： | 1 |
| 12 | Direct comparison of levels of genetic variation among barley accessions detected by RFLPs, AFLPs, SSRs and RAPDs显示文摘 | Russell J R Fuller J D Macaulay M | 1997 | Theoretical and Applied Genetics1997，95，： | 1 |
| 13 | Induction of adhesion molecule expression in liver ischemia-reperfusion injury is associated with impaired hepatic parenchymal microcirculation 显示文摘 | Eiwahsh M Seifalian AM Fuller BJ | 2004 | Br J Surg2004，91，8： | 1 |
| 14 | Functional as ressrnent of chest wall integrity after methlmethacrylate reconstruction显示文摘 | LARDINOIS D MULLER M FULLER M | 2000 | Ann Thorac Surg2000，69，3： | 1 |
| 15 | Magnetic domain observation by electron microscopy显示文摘 | Hale M E Fuller H W Rubinstein H | 1959 | J Appl Phys1959，30，： | 1 |
| 16 | Thermal stability of LixCoO2,LixNiO2 and LixMnO2 and consequences for the safety of Li-ion cells显示文摘 | DAHN J R FULLER E W OBROVAC M | 1994 | Solid State Ionics1994，69，： | 1 |
| 17 | Imaging Techniques for the Assessment of Body Composition 显示文摘 | Fuller M F Fowler P A McNeil1 G | 1994 | Nutr1994，124，： | 1 |
| 18 | Modeling of galvanostatic charge and discharge of the lithium/polymer/insertion cell显示文摘 | Doyle M Fuller T F Newman J | 1993 | Journal of the Electrochemical Society1993，140，6： | 1 |
| 19 | Effect of municipal solid waste leachate composition on zinc immigration through soil 显示文摘 | Boyle M Fuller H W | 1987 | Journal of Environmental Quality1987，16，： | 1 |
| 20 | Direct comparison of levels of genetic variation amongbarley accessions detected by RFLPs,AFLPs,SSRs and RAPDs显示文摘 | Russell J R Fuller J D Macaulay M | 1997 | Theoretical and Applied Genetics1997，95，： | 1 |
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