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| 1 | Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin显示文摘AIM: To investigate the inhibitory effect of kallistatin (KAL) on angiogenesis and HCT-116 xenograft tumor growth. METHODS: Heterotopic tumors were induced by subcutaneous injection of 2 × 106 HCT-11 cells in mice. Seven days later, 2 × 1011 rAAV-GFP or rAAV-KAL was injected intratumorally (n = 5 for each group). The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining. RESULTS: Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% (171 ± 52 mm3) at d 21 after virus infection compared to the control group (776 ± 241 mm3). Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL. rAAV-KAL also decreased the proportion of proliferating cells (Ki-67 positive cells) in tumors compared with the control group.CONCLUSION: rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer. | Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan Li Kin-Wah Chu Peter WC Fung Nagy Habib Farzin Farzaneh Rui-An Xu | 2007 | World Journal of Gastroenterology2007，13，34： | 15 |
| 2 | 基于两级模糊控制器的独立负载液压系统的压力流量复合控制特性研究(英文)显示文摘目的:常规负载口独立控制研究多采用商业阀进行,因其阀芯位移控制器为封闭式结构,所以阀芯位移的动态特性难以调整,进而影响了系统的压力和流量控制性能。本文旨在探讨负载口独立控制系统中阀芯位移特性对系统压力和流量控制的影响,并研究提高系统压力和流量控制性能的方法。创新点:1.设计基于两级模糊比例积分微分(PID)的压力和流量控制器;2.设计基于阀芯位移反馈的流量控制器;3.建立试验模型,成功实现液压系统高动态压力流量复合控制。方法:1.通过理论分析得到影响系统压力和流量的关键因素(公式(9)和(13));2.提出位移控制为内环、压力和流量控制为外环的两级模糊PID控制算法,并开发相应的控制系统(图2~4);3.通过仿真和实验分析,验证本文提出的控制器所具有的阀芯位移、系统压力和流量的控制效果(图13~18)。结论:1.两级模糊PID控制器具有较好的系统压力和流量控制效果;2.基于阀芯位移反馈的流量控制器具有较高的流量控制精度;3.运用本文设计的可编程控制系统进行液压系统的压力流量复合控制,稳定时间小于200 ms,使系统动态特性得到提高。 | Qi ZHONG Bin ZHANG Hui-ming BAO Hao-cen HONG Ji-en MA Yan REN Hua-yong YANG Rong-fong FUNG | 2019 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2019，0，3： | 5 |
| 3 | Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis显示文摘BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation. | Ka Wing Ma Kelly Hiu Ching Wong Albert Chi Yan Chan Tan To Cheung Wing Chiu Dai James Yan Yue Fung Wong Hoi She Chung Mau Lo Kenneth Siu Ho Chok | 2019 | World Journal of Gastroenterology2019，25，36： | 3 |
| 4 | Liver transplantation:would it be the best and last chance of cure for hepatocellular carcinoma with major venous invasion?显示文摘Background:Hepatocellular carcinoma(HCC)with portal vein tumour thrombus(PVTT)signifies advanced disease,whether LT confers any survival superiority over resection remains uncertain.Methods:A propensity score matched(PSM)analysis of liver transplantation(LT)and liver resection(LR)for HCC with PVTT was performed.Results:A consecutive series of 88 patients who received either LT(10 DDLTs and 3 LDLTs)or LR(n=75)respectively were recruited.Before PSM,the LT group has a higher MELD score(17.3 vs.7.8,P<0.001),lower serum AFP levels(96 vs.2,164 ng/mL,P=0.017)and smaller tumour size(4 vs.10 cm,P<0.001).The 5-year overall survival for LT and LR were 55.4%and 15.9%respectively(P=0.007).After matching for serum AFP levels and tumour size,1-,3-and 5-year overall survival for LT were 81 ng/mL,3.9 cm,80%,70%and 70%and the corresponding rates for LR were 1,417 ng/mL,5.3 cm,51.8%,19,6%and 9.8%(P value=0.12,0.27 and 0.009 respectively).Conclusions:LT is associated with significantly better oncological outcomes in HCC patients with PVTT involving the lobar or segmental level.A modest expansion of selection criteria to include small HCC with segmental PVTT should be considered. | Ka Wing Ma Albert Chi Yan Chan Kenneth Siu Ho Chok Wong Hoi She Tan To Cheung Wing Chiu Dai James Yan Yue Fung Chung Mau Lo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 5 | Validated model for prediction of recurrent hepatocellular carcinoma after liver transplantation in Asian population显示文摘BACKGROUND Liver transplantation(LT) is regarded as the best treatment for both primary and recurrent hepatocellular carcinoma(HCC). Post-transplant HCC recurrence rate is relatively low but significant, ranging from 10%-30% according to different series. When recurrence happens, it is usually extrahepatic and associated with poor prognosis. A predictive model that allows patient stratification according to recurrence risk can help to individualize post-transplant surveillance protocol and guidance of the use of anti-tumor immunosuppressive agents.AIM To develop a scoring system to predict HCC recurrence after LT in an Asian population.METHODS Consecutive patients having LT for HCC from 1995 to 2016 at our hospital were recruited. They were randomized into the training set and the validation set in a60:40 ratio. Multivariable Cox regression model was used to identity factors associated with HCC recurrence. A risk score was assigned to each factor according to the odds ratio. Accuracy of the score was assessed by the area under the receiver operating characteristic curve.RESULTS In total, 330 patients were eligible for analysis(183 in training and 147 invalidation). Recurrent HCC developed in 14.2% of them. The median follow-up duration was 65.6 mo. The 5-year disease-free and overall survival rates were78% and 80%, respectively. On multivariate analysis, alpha-fetoprotein > 400 ng/mL [P = 0.012, hazard ratio(HR) 2.92], sum of maximum tumor size and number(P = 0.013, HR 1.15), and salvage LT(P = 0.033, HR 2.08) were found to be independent factors for disease-free survival. A risk score was calculated for each patient with good discriminatory power(c-stat 0.748 and 0.85, respectively,in the training and validation sets). With the derived scores, patients were classified into low-(0–9), moderate-(> 9–14), and high-risk groups(> 14), and the risk of HCC recurrence in the training and validation sets was 10%, 20%, 54%(cstat 0.67) and 4%, 22%, 62%(c-stat 0.811), accordingly. The risk stratification model was validated with chi-squared goodness-of-fit test(P = 0.425).CONCLUSION A validated predictive model featuring alpha-fetoprotein, salvage LT, and the sum of largest tumor diameter and total number of tumor nodule provides simple and reliable guidance for individualizing postoperative surveillance strategy. | Ka Wing Ma Wong Hoi She Albert Chi Yan Chan Tan To Cheung James Yan Yue Fung Wing Chiu Dai Chung Mau Lo Kenneth Siu Ho Chok | 2019 | World Journal of Gastrointestinal Oncology2019，11，4： | 2 |
| 6 | Mapping of retinal function in diabetic retinopathy using the multifocal electroretinogram显示文摘 | Palmowski AM Sutter EE Bearse MA Fung W | 1997 | Invest Ophthalmol Vis Sci1997，38，12： | 1 |
| 7 | Estimation of the basic reproduction number of enterovirus 71 and coxsackie virus A16 in hand, foot and mouth disease outbreaks 显示文摘 | Ma E Fung C Yip SH | 2011 | Pediatr Infect Dis J2011，30，8： | 1 |
| 8 | Oncogenic role of eIF-5A2 in the development of ovarian cancer显示文摘 | Guan XY Fung JM Ma NF | 2004 | Cancer Res2004，64，12： | 1 |
| 9 | Statistical Fluctua-tion Analysis for Measurement Device IndependentQuantum Key Distribution 显示文摘 | X F Ma C H F Fung M Razavi | 2012 | Physical Review A2012，86，05： | 1 |
| 10 | Management of chronic hepatitis B: Canadian Association for the Study of the Liver consensus guidelines 显示文摘 | Coffin CS Fung SK Ma MM | 2012 | Can J Gastroenterol2012，26，12： | 1 |
| 11 | Variety of TEM-, SHV-, and CTX-M-type beta-lactamases present in recent clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae from Taiwan显示文摘 | Ma L Chang FY Fung CP | 2005 | Microb Drug Resist2005，11，1： | 1 |
| 12 | Statistical Fluctuation Analysis for Measurement-Device- Independent Quantum Key Distribution显示文摘 | MA Xiongfeng FUNG C F RAZAVI M | 2012 | Physical Review A2012，86，05： | 1 |
| 13 | Acrodermatitis en-teropathica and an overview of zinc metabolism显示文摘 | Maverakis E Fung MA Lynch PJ | 2007 | J Am AcadDermatol2007，56，1： | 1 |
| 14 | 'Z-plasty' modi- fication of ulnar-based fasciocutaneous flap for closure of the radial forearm flap donor defect显示文摘 | Bashir MA Fung V Kernohan MD | 2010 | Ann Plast Surg2010，64，1： | 1 |
| 15 | Mapping of retinal function in diabetic retinopathy using the multifocal electroretinogram 显示文摘 | Palmowski AM Sutter EE Bearse MA Fung W | 1997 | Invest Ophthalnol Vis Sci1997，38，12： | 1 |
| 16 | Epstein-Barr virus-induced posttransplant lymphoproliferative disorders, ASI/ASIP EBV-PTLD Task Fome and The Mayo Clinic Organized International Consensus Development Meeting 显示文摘 | Paya CV Fung JJ Nalesnik MA | 1999 | Transplantation1999，68，10： | 1 |
| 17 | Estimation of the basic reproduction number of enterovirus 71 and Coxsackievirus A16 in hand, foot, and mouth disease outbreaks 显示文摘 | Ma E Fung C Yip SH | 2011 | Pediatr Infact Dis J2011，30，8： | 1 |
| 18 | Estimation of the basic reproduction number of enterovirus 71 and coxsackievirus A16 in hand, foot, and mouth disease outbreaks显示文摘 | Ma E Fung C Yip S H | 2011 | Pediatr Infect Dis J2011，30，8： | 1 |
| 19 | Local Identity and Nationalism: Surveys on Hong Kong Cultural Identification 1996 -2006 显示文摘 | Eric Ma Anthony Fung | 2007 | The Chinese Jour- nal of Communication and Society2007，，3： | 1 |
| 20 | Estimation ofthe basic reproduction number of enterovirus 71and cox-sackievirus A16in hand,foot,and mouth disease out-breaks显示文摘 | Ma E Fung C Yip S H Wong C | 2011 | Pediatr Infect Dis J2011，30，8： | 1 |
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