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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 3 | Kondo effect versus indirect exchange in the two-impurities Anderson model: A Monte Carlo study显示文摘 | FYE R M HIRSH J E SCALAPINO D J | 1987 | Phys Rev B1987，35，： | 1 |
| 4 | Tree-ring reconstructed megadroughts over North America since AD 1300显示文摘 | Stahle D W Fye F K Cook E R | 2007 | Climatic Change2007，83，12： | 1 |
| 5 | The myocarditis of systemic lupus erythematosus: association with myositis 显示文摘 | Bornstein D C Fye W B Arnett F C | 1978 | Ann Intern Med1978，89，： | 1 |
| 6 | Piezoelectric windmill : a novel so- lution to remote sensing显示文摘 | Priya S Chen C T Fye D | 2005 | Japanese Journal of Applied Physics2005，44，1： | 1 |
| 7 | Tree-ring reconstructed megadroughts over North America since AD 1300显示文摘 | Stahle D W Fye F K Cook E R | 2007 | Climatic Change2007，83，12： | 1 |
| 8 | Piezoelectric wind- mill:a novel solution to remote sensing 显示文摘 | Priya S Chen C T Fye D | 2005 | Japanese Journal of Applied Physics2005，44，3： | 1 |
| 9 | 查看详情显示文摘 | Fye R M Martins M J Scalapino D J Wagner J Hanke W | | 0，，： | 1 |
| 10 | Gemfibrozil for the secondary prevention of coronary Heart Disease In Men with Low Levels of High-Density Lipoprotein Cholesterol 显示文摘 | Rubins HB Robins SJ Collins D Fye CL Anderson JW Elam MB Faas FH Linares E Schaefer EJ Schectman G Wilt TJ Wittes J | 1999 | NEngl J Med1999，341，8： | 1 |
| 11 | Piezoelectric Windmill: A Novel Solution to Remote Sensing显示文摘 | Priya S Chen C T Fye D | 2005 | Japanese Journal of Applied Physits2005，44，3： | 1 |
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