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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma显示文摘瞄准:在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法:COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果:COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论:COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC,从而导致致癌作用。 | Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 3 | 气力输送管道压降预测影响的数值模拟研究显示文摘气力输送管道压降的预测有利于合理设计供风系统。建立了一气力输送实验装置,对某些截面的压力进行了实验测试。运用CFD仿真软件Fluent,建立了3维气固两相湍动双流体压降预测模型,通过对该气力输送系统的水平弯管进行的仿真研究,得到了与实验结果吻合较好的模型,并运用该模型分析了几个主要参数对气力输送系统压降预测的影响。 | 马爱纯 Williams R C 周孑民 Jones M G | 2010 | 武汉理工大学学报2010，32，23： | 9 |
| 4 | 使用二甲双胍的禁忌证 证据显示应该修改二甲双胍的禁忌证显示文摘在英国前瞻性糖尿病研究(UNPOS)中,2型糖尿病患者被随机分入二甲双胍、磺酰脲类或胰岛素强化治疗组,3组患者取得了相似的血糖控制效果,微血管并发症终点事件显著降低。该项研究显示,肥胖患者使用二甲双胍治疗可以降低心血管事件的发生,二甲双胍治疗组的患者没有低血糖事件。 | G C Jones J P Macklin W D Alexander 李玉秀 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 5 | Memory,delusions,and the development of acute posttraumatic stress disorder-related symptoms after intensive care显示文摘 | Jones C Griitiths RD Humphfis G | 2001 | Crit Care Med2001，29，3： | 1 |
| 6 | Virus infection expands a biased subset of T ceils that bind tetrameric class I peptide complexes 显示文摘 | COLES R M JONES C M BROOKS A G | 2003 | Eur J Immunol2003，33，6： | 1 |
| 7 | Thermal Properties of DMNB, A Detection Agent for Exploslves显示文摘 | JONES D E G LIGHTFOOT P D FOUCHARD R C | 2002 | Thermochimic Acta2002，388，12： | 1 |
| 8 | Pereutaneous tracheostomy: a 6 yr prospective evaluation of the single tapered dilator technique显示文摘 | DEMPSEY G A GRANT C A JONES T M | 2010 | Br J Anaesth2010，105，6： | 1 |
| 9 | A first global pro-duction,emission,and environmental inventory for perfluorooctane sulfonate显示文摘 | Paul A G Jones K C Sweetman A J | 2009 | Environmental Science&Technology2009，43，2： | 1 |
| 10 | A first global pro-duction,emission,and environmental inventory for perfluorooctane sulfonate显示文摘 | Paul A G Jones K C Sweetman A J | 2009 | Environmental Science&Technology2009，43，2： | 1 |
| 11 | Treatment of proximal humerus fractures with polarus nail fixation 显示文摘 | Agel J Jones C B Sanzone A G | 2004 | J Shoulder Elbow Surg2004，13，2： | 1 |
| 12 | Disturbed memory amnesia related to intensive care显示文摘 | JONES C GRIFFITHS R D HUMPHRIS G | 2000 | Memory2000，8，2： | 1 |
| 13 | Influence of nitrogen source and availability on amino acids pigments and tissue nitrogen of Gracilaria eduils (Rhodophyta) 显示文摘 | Dennison W C Stewart G R | 1996 | J Phycol1996，32，： | 1 |
| 14 | Imbalanced gp130 signalling in ApoE-deficient mice protects against atheroscle- rosis显示文摘 | Jones G W McLeod L Kennedy C L | 2015 | Atherosclerosis2015，238，2： | 1 |
| 15 | A functional analysis of mouse models of cardiac disease through metabolic profiling显示文摘 | Jones G L Sang E Goddard C | 2005 | J Biol Chem2005，280，9： | 1 |
| 16 | Trace metals in corals from the Great Barrier Reef显示文摘 | Denton G R Jones C B | 1986 | Marine Pollution Bullet in1986，17，： | 1 |
| 17 | Experimental approaches and analytical techniques for determining organic compound bound residues in soil and sediment 显示文摘 | Northcott G L Jones K C | 2000 | Environ Pollution2000，108，： | 1 |
| 18 | Nonclassical effects in the photon-added thermal state显示文摘 | Jones G N Haight J Lee C T | 1997 | Quantum and Semiclass Opt1997，，9： | 1 |
| 19 | Is Adherence to weight monitoring or weight-based diuretic self-adjustment associated with fewer heart failure-related emergency department visits or hospitalizations 显示文摘 | Jones C D Holmes G M | 2012 | J Card Fail2012，18，7： | 1 |
| 20 | Sevoflurane anesthesia does not impair acquisition learning or memory in the Morris water maze in young adult and aged rats 显示文摘 | Callaway J K Jones N C Royse A G | 2012 | Anesthesiology2012，117，5： | 1 |
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