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您的检索式：作者名="G.Aleph Prieto"
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| 1 | Neurological manifestations with jugular vein thrombosis linked to an inflammatory profile may be a sequela of long COVID显示文摘More than 670 million cases of coronavirus disease 2019(COVID-19)have been recorded worldwide in the 3 years since the start of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic.About 45%of survivors of COVID-19 develop a syndrome known as long-term COVID,in which symptoms persist even months after the acute infection.About 76%of patients with long COVID experience neurological manifestations.Moreover,patients who have survived COVID-19 have an increased risk of cerebral venous thrombosis.This case report describes a 41-year-old woman who developed neurological manifestations associated with jugular vein thrombosis 24 h after administration of the Oxford–AstraZeneca(ChAdOx1 nCoV-19)vaccine(AstraZeneca-Serum Institute of India).She had been infected with SARS-CoV-2 three months before vaccination.Although initially suspected to be a case of vaccine-induced immune thrombotic thrombocytopenia(VITT)in view of her recent vaccination,the patient did not have any hallmarks of VITT,such as thrombocytopenia,an increased D-dimer level,or antibodies against platelet factor-4.Moreover,the neurological manifestations were associated with a high concentration of inflammatory cytokines,including interleukin(IL)-6,IL-17A,and IL-21,and elevated neutrophil levels in cerebrospinal fluid,suggesting that inflammatory immune components had a role in the development of thrombotic events and pointing to an alternative diagnosis.In this case,the laboratory results indicated that the neurological manifestations associated with jugular vein thrombosis were not associated with VITT.Therefore,we propose that the thrombosis of the left jugular vein was a sequela of SARS-CoV-2 infection. | Elizabeth Mendoza-Portillo Estefania Aleman-Navarro G.Aleph Prieto Yvonne Rosenstein Jose J.Lozano-Nuevo Araceli Perez-Lopez | 2023 | Neuroprotection2023，1，2： | 0 |
| 2 | On the road towards the global analysis of human synapses显示文摘Synapses are essential units for the flow of information in the brain.Over the last 70 years,synapses have been widely studied in multiple animal models including worms,fruit flies,and rodents.In comparison,the study of human synapses has evolved significantly slower,mainly because of technical limitations.However,three novel methods allowing the analysis of molecular,morphological,and functional properties of human synapses may expand our knowledge of the human brain.Here,we briefly describe these methods,and evaluate how the information provided by each unique approach may contribute to the functional and anatomical analysis of the synaptic component of human brain circuitries.In particular,using tissue from cryopreserved human brains,synaptic plasticity can be studied in isolated synaptosomes by fluorescence analysis of single-synapse long-term potentiation(FASS-LTP),and subpopulations of synapses can be thoroughly assessed in the ribbons of brain tissue by array tomography(AT).Currently,it is also possible to quantify synaptic density in the living human brain by positron emission tomography(PET),using a novel synaptic radio-ligand.Overall,data provided by FASS-LTP,AT,and PET may significantly contribute to the global understanding of synaptic structure and function in both healthy and diseased human brains,thus directly impacting translational research. | G.Aleph Prieto Carl W.Cotman | 2017 | Neural Regeneration Research2017，12，10： | 0 |
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