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| 1 | Damage control orthopaedics: State of the art显示文摘Damage control orthopaedics(DCO) originally consisted of the provisional immobilisation of long bone-mainly femur-fractures in order to achieve the advantages of early treatment and to minimise the risk of complications, such as major pain, fat embolism, clotting, pathological inflammatory response, severe haemorrhage triggering the lethal triad, and the traumatic effects of major surgery on a patient who is already traumatised(the 'second hit' effect). In recent years, new locations have been added to the DCO concept, such as injuries to the pelvis, spine and upper limbs. Nonetheless, this concept has not yet been validated in well-designed prospective studies, and much controversy remains.Indeed, some researchers believe the indiscriminate application of DCO might be harmful and produce substantial and unnecessary expense. In this respect, too,normalised parameters associated with the acid-base system have been proposed,under a concept termed early appropriate care, in the view that this would enable patients to receive major surgical procedures in an approach offering the advantages of early total care together with the apparent safety of DCO. This paper discusses the diagnosis and treatment of severely traumatised patients managed in accordance with DCO and highlights the possible drawbacks of this treatment principle. | Enrique Guerado Maria Luisa Bertrand Juan Ramon Cano Ana María Cerván Adolfo Galán | 2019 | World Journal of Orthopedics2019，10，1： | 16 |
| 2 | Efficacy of bevacizumab-containing chemotherapy in metastatic colorectal cancer and CXCL5 expression: Six case reports显示文摘BACKGROUND In metastatic colorectal cancer(mCRC),the anti-vascular endothelial growth factor drug bevacizumab(BVZ)plus chemotherapy significantly improves progression-free survival compared to chemotherapy(CT)alone.This benefit is not,however,observed in all patients.While increased chemokine CXCL5 gene expression promoting angiogenesis has been proposed as a prognostic mCRC biomarker,few studies have examined its relationship with drug efficacy.This study sought to analyze tumor CXCL5 gene expression in six patients with different efficacy of BVZ-containing CT in terms of the tumor response to treatment.CASE SUMMARY We report six cases of stage IV KRAS-mutated mCRC.Patients were given first line treatment with BVZ-containing chemotherapy in University Hospital of Fuenlabrada.The six patients differed in terms of primary tumor location(right/left side),tumor burden(mostly hepatic and peritoneal disease)and clinical disease course.Before treatment onset,total RNA was isolated from paraffinated tumor biopsy specimens and CXCL5 gene expression quantified through conventional RT-qPCR procedures.Our main finding was that CXCL5 expression levels were several times higher in three patients with lower progression free survival(under 6 mo)from the start of treatment.CONCLUSION A higher expression of CXCL5 was observed in the three patients showing worse tumor response to treatment. | Apolonia Novillo María Gaibar Alicia Romero-Lorca María Fuencisla Gilsanz Laura Beltrán Miguel Galán Beatriz Antón Diego Malón Amalia Moreno Ana Fernández-Santander | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 3 | Cryopresevation of cattle oocytes: effects of meiotic stage, cycloheximide treatment , and vitrification procedure显示文摘 | Le Gal F Massip A | 1999 | Cryobiology1999，38，： | 2 |
| 4 | A framework for modeling and evaluating automatic semantic reconciliation显示文摘 | Gal A Anaby-Tavor A Trombetta A | 2003 | VLDB Journal2003，14，1： | 1 |
| 5 | Investigation and treat- ment of repeated implantation failure following IVF-ET 显示文摘 | Margalioth E J Ben-Chetrit A Gal M | 2006 | HumReprod2006，21，12： | 1 |
| 6 | Deoxyribonucle- ic acid fingerprint comparisons between selected populations of chickens 显示文摘 | DUNNINGTON E A GAL O SIEGEL P B | 1991 | Pouh Sci1991，70，3： | 1 |
| 7 | A Cognitive Model of Crowd Behavior Based on Social Comparison Theory 显示文摘 | Gal A Kaminka Natalie Fridman | 2006 | American Association for Artificial Intelligence (S0738-4602)2006，7，： | 1 |
| 8 | Lymphoid hypophysitis associated with sudden maternal death: report of a case review of the literature显示文摘 | Gal R Schwartz A Gukovsky-Oren S | 1986 | Obstet Gyneeol Surv1986，41，10： | 1 |
| 9 | Density dependence in kaonic atom显示文摘 | FRIEDMAN E GAL A BATTY C J | 1993 | Phys Lett B1993，308，12： | 1 |
| 10 | Investigation and treat-ment of repeated implantation failure following IVF-ET显示文摘 | Margalioth EJ Ben-Chertrit A Gal M | 2006 | HumReprod2006，21，12： | 1 |
| 11 | Investigation and treatment of repeated implantation failure following IVF-ET显示文摘 | Margalioth EJ Ben-Chetrit A Gal M | 2006 | Hum Reprod2006，21，12： | 1 |
| 12 | Erol-L alpha plays a key role in a HIF- 1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer 显示文摘 | May D hin A Gal O | 2005 | Oncogene2005，24，6： | 1 |
| 13 | Consuming Now or Later? The Interactive Effect of Timing and Attribute Alignability显示文摘 | Malkoc Selin A Gal Zauberman Canan Ulu | 2005 | Psychological Science2005，16，5： | 1 |
| 14 | Managing uncertainty in schema matching with top-k schema mappings显示文摘 | Gal A | 2006 | Journal on Data Semantics2006，6，： | 1 |
| 15 | Gemcitabine monotherapy in elderly patients with advanced non-small cell lung cancer:a muhicenter phase Ⅱ study显示文摘 | Ricci S Antonuzzo A Gal l i L | 2000 | Lung Cancer2000，27，2： | 1 |
| 16 | Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa显示文摘 | GAL A LI Y THOMPSON D A | 2000 | Nature Genetics2000，26，3： | 1 |
| 17 | Monofunctional epoxy - POSS dispersed in epoxy - a- mine networks : Effect of a prereaction on the morphology and crystallinity of POSS domains 显示文摘 | ZUCCHI I A GAL - ANT M J WILLIAMS R J J | 2007 | Macromolecules2007，40，： | 1 |
| 18 | Density dependence of the ∑ nucleus optical potential derived form ∑^- atom data显示文摘 | BATTY C J FRIEDMAN E GAL A | 1994 | Phys Lett1994，335，： | 1 |
| 19 | CD5 immunuoreactivity of epithelial cells in thymic carcinoma and CASTLE using paraffinembeded tissue显示文摘 | Berezowski K Grimes MM Gal A et el | 1996 | Am J CAin Pathol1996，106，4： | 1 |
| 20 | Investiga-tion and treatment of repeated implantation failure fol-lowing IVF-ET 显示文摘 | Margalioth EJ Ben-Chetrit A Gal M | 2006 | Hum Reprod2006，21，12： | 1 |
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