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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Development of a PCR test to diagnose Haemophilus parasuis infections显示文摘 | Oliveira S Galina L Pijoan C | | 0，，06： | 1 |
| 3 | Sarcoplasmic calcium-binding protein is an EF-hand–type protein identified as a new shrimp allergen显示文摘 | Rosalía Ayuso Galina Grishina María Dolores Ibá?ez Carlos Blanco Teresa Carrillo Ramon Bencharitiwong Silvia Sánchez Anna Nowak-Wegrzyn Hugh A. Sampson | 2009 | The Journal of Allergy and Clinical Immunology2009，，1： | 1 |
| 4 | A bacterial cytokine 显示文摘 | Galina V Mukamolova GV Arseny S | 1998 | Microbilogy1998，95，15： | 1 |
| 5 | Acoustic emission monitoring of rolling element bearings 显示文摘 | Hawman M W Galinaitis W S | 1988 | Ultrasonics symposium1988，，： | 1 |
| 6 | Development of a PCR test to diagnose Haemophilus parasuis in fections 显示文摘 | OLIVEIRA S GALINA L PIJOAN C | 2001 | Vet Di- agn Invest2001，13，6： | 1 |
| 7 | Naturally - farrowed, artificially - reared pigs as an alternative model forexperimental infection by Haemophilus parasuis显示文摘 | Oliveira S Galina L Blanco I | 2003 | Can J Vet Res2003，67，2： | 1 |
| 8 | Naturally-farrowed,artifi-cially-reared pigs as an alternative model for experimental infec-tion by Haemophilus parasuis显示文摘 | Oliveira S Galina L Blanco I | 2003 | Can J Vet Res2003，67，2： | 1 |
| 9 | Development of a PCR test to diagnose Haemophilus parasuis infections 显示文摘 | OLIVEIRA S GALINA L PIJOAN C | 2001 | J Vet Diagn In- vest2001，13，6： | 1 |
| 10 | Development of a PCR test to diag- nose Haemophilus parasuis infections显示文摘 | Oliveira S Galina J Pijoan C | 2001 | Vet Diagn Invest2001，13，6： | 1 |
| 11 | Macrophage Myeloperoxi- dase Regulation by Granulocyte Macrophage Colony - Stimulating Factor in Human Atherosclerosis and Implications in Acute Coronary Syndromes 显示文摘 | Sugiyama S Okada Y Galina K | 2001 | The American Journal of Pathology2001，158，3： | 1 |
| 12 | Development of a PCR test to diag nose Haemophilus parasuis infections显示文摘 | Oliveira S Galina L Pijoan C | 2001 | J Vet Diagn Invest2001，13，6： | 1 |
| 13 | Development of a PCR test to diagnose Haemophilus parasuis infections显示文摘 | Oliveira S Galina L Pijoan C | 2001 | J Vet Diagn Invest2001，13，6： | 1 |
| 14 | Comparison be- tween Haemophilus parasuis infection in colostrums- deprived and sow-reared piglets显示文摘 | Blanco I Galina P L Oliveira S | 2004 | Vet Mierobiol2004，103，12： | 1 |
| 15 | Standard chemotherapy with or without bevacizumab in advanced ovarian cancer: quality-of-life outcomes from the International Collaboration on Ovarian Neoplasms (ICON7) phase 3 randomised trial显示文摘 | Dan Stark Matthew Nankivell Eric Pujade-Lauraine Gunnar Kristensen Lorraine Elit Martin Stockler Felix Hilpert Andrés Cervantes Julia Brown Anne Lanceley Galina Velikova Eduardo Sabate Jacobus Pfisterer Mark S Carey Philip Beale Wendi Qian Ann Marie Swart | 2013 | Lancet Oncology2013，，： | 1 |
| 16 | Development of a PCR test to diagnose Haernophilus parasuis infec- tions显示文摘 | Oliveira S Galina L and Pijoan C | 2001 | J Vet Diagnostic Invest2001，13，6： | 1 |
| 17 | Compensation for hysteresis using bivariate preisach models显示文摘 | Galinaitis W S Rogers R C | 1997 | SPIE1997，3039，： | 1 |
| 18 | A bacterial cytokine显示文摘 | Galina V Mukamolova GV Arseny S | 1998 | Microbilogy1998，95，15： | 1 |
| 19 | Development of a PCR test to diagnose Haemophilus parasuls infections显示文摘 | Oliveira S Galina L Pijoan C | 2001 | Vet Diagn Invest2001，13，6： | 1 |
| 20 | Development of a PCR test to diag- aose Haemophilus parasuis infections显示文摘 | Oliveira S Galina L Pijoan C | 2001 | J Vet Diagn Invest2001，13，6： | 1 |
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