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| 1 | Probiotics and prebiotics in chronic inflammatory bowel diseases显示文摘The prokaryotic and eukaryotic cells of the colon exist in a highly complex, but harmonious relationship. Disturbances in this remarkable symbiosis can result in the development of inflammatory bowel diseases (IBD). Although the etiology of IBD is not entirely understood, it is known that the chronic inflammation of Crohn’s disease, ulcerative colitis and chronic pouchitis are a result of an overly aggressive immune response to the commensal intestinal flora in genetically susceptible hosts. Recent studies have enhanced our ability to understand the interaction between the host and its intestinal microflora and the role the microflora plays in maintaining intestinal homeostasis. As we begin to understand the benefi ts conferred to the intestine by the microflora, the notion of modifying the composition of the bacterial load to improve human health has arisen. A signifi cant body of research now exists investigating the role of probiotics and prebiotics in ameliorating chronic intestinal inflammation. This article will begin with an overview of the role of the commensal microflora in maintaining mucosal immune homeostasis, and how a dysregulated immune response to the intestinal microflora results in IBD. This will be followed by a summary of the use of probiotics and prebiotics in experimental and human IBD. | Julia B Ewaschuk Levinus A Dieleman | 2006 | World Journal of Gastroenterology2006，12，37： | 41 |
| 2 | MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth显示文摘一幅 microRNA 表示屏幕被执行从良性的 melanocytic nevi 在 laser-microdissected 纸巾分析 157 不同 microRNAs (n = 10 ) 并且主要恶意的黑瘤(n = 10 ) ,用量的即时 PCR。微分表示被作出对有利的裁决 72 microRNAs。microRNAs 的 let-7 家庭的成员是显著地, down 作为与良性的 nevi 相比在主要黑瘤调整了,为是的这些分子的一个可能的角色暗示肿瘤在恶意的黑瘤压制 ors。有趣地,类似的调查结果为肺和结肠癌被描述了。在黑瘤房间试管内 down 的 let-7b 的 Overexpression 调整了 cyclins 的表示 D1, D3,和 A,和 cyclin 依赖的 kinase (Cdk ) 4,所有哪个被描述了在黑瘤开发起一个作用。蛋白质表示上的 let-7b 的效果由于单个 mRNAs 的 3'-untranslated 区域(3'UTRs ) 指向,为 cyclin D1 由记者基因分析例示。与它细胞周期管理者上的 down modulating 效果一致, let-7b 禁止了细胞周期前进和黑瘤细胞的抛锚无关的生长。总起来说,这些调查结果不仅指向早黑瘤开发的新规章的机制,而且可以打开大街因为未来指向了这个肿瘤的治疗。 | Julia Schultz Peter Lorenz Gerd Gross Saleh Ibrahim Manfred Kunz | 2008 | Cell Research2008，18，5： | 45 |
| 3 | 戒烟与复吸影响因素及戒烟者健康状况分析显示文摘目的揭示戒烟水平、戒烟与复吸原因、成功戒烟的影响因素及与其健康状况的关系,为在中国提出更有针对性的控烟对策提供参考。方法利用两次具有全国代表性的中国国家卫生服务调查数据,采用分组分析、logistic回归分析、年龄标准化等方法分析戒烟相关指标和影响因素。结果2003年只有6.1%的戒烟率,7.9%的正在吸烟者有戒烟意愿,老年吸烟者、城市地区、高收入者、患有慢性病者或自感健康较差者比较容易戒烟成功,而户中有多名吸烟者、经常饮酒者不易戒烟成功;戒烟者本身健康状况已较差;54%的复吸者报告是因为'控制不住烟瘾',约29%的人是因为社交或社会环境影响而复吸。结论中国吸烟者的戒烟水平和意愿均较低、因病而戒烟表明戒烟太晚太被动;除现有控烟政策外,更有针对性的控烟活动如对年轻吸烟者、农村地区吸烟者、多吸烟者住户和促进未病先戒等活动也是迫切需要的。 | 钱军程 饶克勤 高军 Julia Critchley 汤胜蓝 蔡敏 | 2009 | 中国卫生统计2009，26，2： | 34 |
| 4 | 昆虫抗药性机理:行为和生理改变及解毒代谢增强(英文)显示文摘杀虫剂抗性是指“生物的一个品系发展了对该生物正常种群中大多数个体具有致死作用剂量的杀虫药剂的能力”。行为改变、生理学上的变化或代谢解毒等抗性机制能够降低毒物到达靶标的有效剂量。行为抗性是指减少昆虫与毒物接触或使昆虫能够存活于对大多数对正常个体致死(或有害)的环境中的任何行为。生理学改变的机制包括杀虫剂对表皮的穿透性降低、增加对药剂阻隔(sequestration)或储存和加速杀虫剂的排泄。细胞色素P450、水解酶和谷胱甘肽S转移酶是杀虫药剂代谢解毒的主要3大酶系。细胞色素P450是一个超基因家族,是生物体内对外源性和内源性化合物解毒代谢或活化最重要的酶系。在许多害虫中发现P450介导的解毒代谢增加导致了对杀虫药剂抗性的增加。谷胱甘肽S转移酶是可溶性的二聚体蛋白,与代谢解毒、大量内源性和外源性化合物的排泄有关,许多昆虫中证明其抗药性与该酶活性增加有关。水解酶实际上是一组异源的酶类,其对抗药性的作用包括通过基因扩增增加酶量,作为结合蛋白隔离杀虫药剂或通过增加酶的活性加强对药剂的水解作用。 | 刘喃喃 朱芳 徐强 Julia W.PRIDGEON 高希武 | 2006 | 昆虫学报2006，49，4： | 27 |
| 5 | Bone–cartilage crosstalk:a conversation for understanding osteoarthritis显示文摘Although cartilage degradation is the characteristic feature of osteoarthritis(OA), it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction(crosstalk) between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage,below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are welldescribed progressive destructive changes in the articular cartilage, which parallel characteristic changes in the underlying bone. This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development. | David M Findlay Julia S Kuliwaba | 2016 | Bone Research2016，4，3： | 27 |
| 6 | Thermal Treatment of Hydrocarbon-Impacted Soils" A Review of Technology Innovation for Sustainable Remediation显示文摘在受烃污染的土壤和底泥的修复处理工艺中,热处理工艺因其能快速且稳定地达到修复标准而占有重要地位。然而,持续高温属于能源密集型操作,且可破坏土壤性质,因此尽管此工艺被广泛应用,关于这些工艺的环境兼容性和可持续性却极少被报道。鉴于此,我们对几个针对烃污染土壤的常用热处理工艺进行了概述,对它们的潜在环境影响进行了评估;并基于能源需求、水需求、系统生态和土壤科学的全面考虑,提出了可持续且影响较小的发展框架。至今还没有一种通用适合的热处理工艺。工艺的恰当选择要根据污染状况(包括环境中存在的烃种类)和场地特征(如被污染土壤的性质、水含量和热敏性)而定。总之,处理工程与土壤科学、生态系统和植物生物学研究的有机结合是攻克技术瓶颈、提高去除率和促进热处理工艺可持续性发展的关键所在。 | Julia E. Vidonish Kyriacos Zygourakis Caroline A. Masiello Gabriel Sabadell Pedro J. J. Alvarez | 2016 | Engineering2016，2，4： | 27 |
| 7 | 洪湖特色水产品对湖水及沉积物中有机氯农药的积累模式显示文摘对洪湖水体、表层沉积物和特色水产品(鲫鱼、莲藕等)进行了调查采样,采用美国EPA方法进行了有机氯农药的提取,用带有电子捕获器的气相色谱(GC-ECD)进行了有机氯农药含量的测定。结果表明:六六六和滴滴涕各异构体在湖水、表层沉积物、特色水产品中绝大部分都有检出,湖水中六六六和滴滴涕的质量浓度远低于其在表层沉积物和特色水产品中的质量分数,这与有机氯农药疏水亲颗粒和溶脂性的特性有关。以分配系数、生物积累因子和生物区系-底泥生物积累因子为基础,建立了洪湖特色水产品对水体及表层沉积物中有机氯农药的积累模式,所得结果能够为洪湖湿地保护与生态恢复措施的决策与制定提供科学依据。 | 苏秋克 祁士华 吴辰熙 胡立嵩 王伟 Ellis Burnet Julia 龚香宜 吕春玲 刘华峰 | 2007 | 地质科技情报2007，26，4： | 26 |
| 8 | 中国大学生吸烟行为和吸烟态度研究显示文摘目的:对我国大学生的吸烟现状进行调查;并检验“吸烟态度与吸烟行为具有一致性”的假设。方法:用问卷法对805名中国大学生进行了研究。结果:大学生中有19.1%的人为当前吸烟者;男生吸烟普遍性显著高于女生;吸烟的普遍性随着年级的增高而增高;大学生对尼古丁没有依赖性;不吸烟者抗烟态度强,吸烟者抗烟态度弱。结论:吸烟态度与吸烟行为具有一致性。 | 吴荣先 Julia A.Lee 章红 | 2002 | 医学理论与实践2002，15，5： | 25 |
| 9 | 一种使用重叠换相法的无刷直流电机平均转矩控制显示文摘提出一种使用重叠换相的平均转矩控制,这种方法可以同时抑制无刷直流电机由反电势畸变和换相引起的转矩脉动。平均转矩控制将每个开关周期内的平均转矩作为控制变量,在每个开关周期内使其等于给定量,因此可以抑制由反电势畸变引起的转矩脉动。而对于换相转矩脉动,该方法结合重叠换相法,对高速时的转矩跌落进行补偿,其中重叠角度通过检测关断相电流的过零点来实现。文中提出的控制方法能够适用不同反电势的无刷直流电机,具有通用性强,控制简单的特点。仿真和实验都验证了这种方法可以有效抑制无刷直流电机由反电势畸变和换相引起的转矩脉动。 | 盛田田 王晓琳 顾聪 单涛 Julia Zhang | 2015 | 中国电机工程学报2015，35，15： | 22 |
| 10 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 11 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 12 | 季节性缺氧水库甲基汞的产生及其对下游水体的影响显示文摘本文采用蒸馏-乙基化结合GC-CVAFS法对贵州红枫湖水库及其各入库和出库河流中的甲基汞时空分布和控制因素进行了研究.在春、秋、冬季节总甲基汞浓度和分布无明显时空变化,在0.053-0.333 ng/L之间.春季河流是水库甲基汞一个重要的输入源.夏季水库下层甲基汞显著升高,缺氧层最高值达0.923 ng/L.同时发现.缺氧层升高的甲基汞主要来自于水体自己产生或上层水体甲基汞的沉降,而不是来自于沉积物的释放.各季节湖水和河流样品的总甲基汞和溶解氧存在显著的负相关关系,Personal相关系数r为-0.81(n=78).在春、秋、冬季节溶解态甲基汞比例略低于颗粒态甲基汞,但在夏季,特别是缺氧层,甲基汞主要以溶解态存在.夏季河流入水经水库蓄水后,到再流出时已经富含甲基汞,出库河流中总甲基汞浓度已达到各入湖河流总甲基汞平均值的5.5倍,很明显在复季红枫湖已成为下游水体甲基汞的输入源,必将会对下游生态系统产生一定影响. | 何天容 冯新斌 李仲根 仇广乐 白微杨 LIANG Lian LU Julia | 2006 | 湖泊科学2006，18，6： | 17 |
| 13 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 14 | Activation of Defense Response Pathways by OGs and Fig22 Elicitors in Arabidopsis Seedlings显示文摘 | Carine Denoux Roberta Galletti Nicole Mammarella Suresh Gopalan Danièle Werck Giulia De Lorenzo Simone Ferrari Frederick M. Ausubel Julia Dewdney | 2008 | Molecular Plant2008，1，3： | 13 |
| 15 | Pollen-inferred vegetation and environmental changes in the central Tibetan Plateau since 8200 yr BP显示文摘The ecotone between alpine steppe and meadow in the central Tibetan Plateau is sensitive to climate changes. Here we used the pollen records from three lakes in this region to reconstruct the evolution of local vegetation and climate since 8200 cal. yr BP. The history of temperature and precipitation was reconstructed quantitatively with multi-bioclimatic indexes and a transfer function from pollen records. Results show that the steppe/meadow dominated during the period of 8200―6500 cal. yr BP, especially 8200―7200 cal. yr BP, indicating the central Tibetan Plateau was controlled by strong monsoon. The steppe dominated during the periods of 6000―4900, 4400―3900, and 2800―2400 cal. yr BP. The steppe decreased gradually and the meadow expanded during the period of 4900―4400 cal. yr BP. Three century-scale drought events occurred during 5800―4900, 4400―3900 and 2800 cal. yr BP, respectively. The first time when the regional climate shifted to the present level was at 6500 cal. yr BP in the central Plateau. Since 3000 cal. yr BP, the temperature and precipitation have decreased gradually to the present level. However, the cold climate between 700―300 cal. yr BP likely corresponds to the Little Ice Age. | LIU Kam-Biu Carrie MORRILL Jonathan T. OVERPECK Julia E. COLE | 2009 | Science China Earth Sciences2009，52，8： | 13 |
| 16 | 响应曲面法优化磷脂酶Lecitase Ultra用于茶油脱胶工艺的研究显示文摘本研究在单因素试验的基础上,利用Box-Benhnken的中心组合试验设计及响应面分析法优化磷脂酶Lecitase Ultra对茶油脱胶的工艺,建立反应时间、反应温度、酶用量与磷脂脱除率之间的数学模型,确立酶法对茶油脱胶的最佳工艺条件,即反应时间4.3h、反应温度47℃、酶用量44mg/kg。在此最佳工艺条件下,茶油脱胶率达89.41%(n=3)。 | 李晶 胡婕伦 谢明勇 聂少平 张彬 JULIA Goh su-yun | 2008 | 食品科学2008，29，9： | 13 |
| 17 | What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis显示文摘AIM To quantify the risk of gastric cancer in first-degree relatives of patients with the cancer. METHODS A comprehensive literature search was performed. Case-control trials comparing the frequency of a positive family history of gastric cancer in patients with gastric cancer, vs non-gastric cancer controls were retrieved. Studies with missed or non-extractable data, studies in children, abstracts, and duplicate publications were excluded. A meta-analysis of pooled odd ratios was performed using Review Manager 5.0.25. We performed subgroup analysis on Asian studies and a sensitivity analysis based on the quality of the studies, type of the outcome, sample size, and whether studies considered only first-degree relatives. RESULTS Thirty-two relevant studies out of 612 potential abstracts(n = 80690 individuals) were included. 19.0% of the patients and 10.9% of the controls had at least one relative with gastric cancer(P < 0.00001). The pooled relative risk for the development of gastric cancer in association with a positive family history was 2.35(95%CI: 1.96-2.81). The Cochran Q test for heterogeneity was positive(P < 0.00001, I 2 = 92%). After excluding the three outlier studies with the highest relative risks, heterogeneity remained significant(P < 0.00001, I 2 = 90%). The result was not different among Asian studies as compared to others and remained robust in several sensitivity analyses. In the 26 studies which exclusively analysed the history of gastric cancer in first-degree relatives, the relative risk was 2.71(95%CI: 2.08-3.53; P < 0.00001). CONCLUSION Individuals with a first-degree relative affected with gastric cancer have a risk of about 2.5-fold for the development of gastric cancer. This could be due to genetic or environmental factors. Screening and preventive strategies should be developed for this highrisk population. | Mohammad Yaghoobi Julia McNabb-Baltar Raheleh Bijarchi Richard H Hunt | 2017 | World Journal of Gastroenterology2017，23，13： | 13 |
| 18 | Boceprevir,GC-376,and calpain inhibitors Ⅱ,Ⅻ inhibit SARS-CoV-2 viral replication by targeting the viral main protease显示文摘A new coronavirus SARS-CoV-2,also called novel coronavirus 2019(2019-nCoV),started to circulate among humans around December 2019,and it is now widespread as a global pandemic.The disease caused by SARS-CoV-2 virus is called COVID-19,which is highly contagious and has an overall mortality rate of 6.35%as of May 26,2020.There is no vaccine or antiviral available for SARS-CoV-2.In this study,we report our discovery of inhibitors targeting the SARS-CoV-2 main protease(Mpro).Using the FRET-based enzymatic assay,several inhibitors including boceprevir,GC-376,and calpain inhibitorsⅡ,andⅫwere identified to have potent activity with single-digit to submicromolar ICs0 values in the enzymatic assay.The mechanism of action of the hits was further characterized using enzyme kinetic studies,thermal shift binding assays,and native mass spectrometry.Significantly,four compounds(boceprevir,GC-376,calpain inhibitorsⅡandⅫ)inhibit SARS-CoV-2 viral replication in cell culture with EC50 values ranging from 0.49 to 3.37μM.Notably,boceprevir,calpain inhibitorsⅡandⅫrepresent novel chemotypes that are distinct from known substrate-based peptidomimetic Mpro inhibitors.A complex crystal structure of SARS-CoV-2 Mpro with GC-376,determined at 2.15(A)resolution with three protomers per asymmetric unit,revealed two unique binding configurations,shedding light on the molecular interactions and protein conformational flexibility underlying substrate and inhibitor binding by Mpro.Overall,the compounds identified herein provide promising starting points for the further development of SARS-CoV-2 therapeutics. | Chunlong Ma Michael Dominic Sacco Brett Hurst Julia Alma Townsend Yanmei Hu Tommy Szeto Xiujun Zhang Bart Tarbet Michael Thomas Marty Yu Chen Jun Wang | 2020 | Cell Research2020，30，8： | 13 |
| 19 | 青藏高原东南缘贡嘎山地区大气总汞时间序列分析及其影响因子显示文摘使用Tekran 2537A大气汞自动分析仪对中国科学院贡嘎山高山生态系统观测试验站磨西基地站(102°72''E 29°92''N)进行了为期1a的大气总汞(TGM)高时间分辨率观测.研究区域的平均TGM浓度为(4±1.38) ng m-3(N=57310),高于全球大气总汞背景值1.5~2.0 ng m-3.不同季节表现出相似的日变化模式,即白天相对夜晚具有较高的TGM浓度,最大TGM浓度出现在中午,最小值出现在日出前,春季和夏季日变化高峰值出现时间比秋季和冬季早1~2h.以冬季TGM浓度最高,为(6.13±1.78) ng m-3;夏季最低,为(3.17±0.67) ng m-3.观测期间不同风向间TGM浓度无显著差异.相关分析表明,TGM浓度与温度、饱和水汽压、降水量、紫外辐射、大气压有显著相关性,这种相关性随季节而变化.贡嘎山地区大气汞浓度主要受局地源的影响和调节. | 朱万泽 付学吾 冯新斌 Julia Y. Lu | 2007 | 生态学报2007，27，9： | 12 |
| 20 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
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