|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Depletion of activated hepatic stellate cell correlates with severe liver damage and abnormal liver regeneration in acetaminophen-induced liver injury显示文摘肝的星形的房间(HSC ) 是为肝的祖先房间(HPC ) 和 hepatocytes 的本地干细胞壁龛的重要部分。然而,它至于激活的 HSC 的产品是否被要求稀释 hepatocyte 损害是不清楚的,提高肝新生,或两个。在这研究,我们由弄空执行了功能研究的损失有 gliotoxin 的激活的 HSC。显著地严重的肝损坏和拒绝的幸存率与激活的 HSC 的弄空被相关,这被表明。而且,减少 HSC 激活导致了增殖的 hepatocytes 的数字的 hepatocyte apoptosis 和 66% 减少的 3 褶层增加。这被戏剧的减少在知道在 hepatocyte 复制期间起来调整的五基因的表示层次伴随。特别地,激活的 HSC 的弄空禁止了被 Pank 积极的房间的减少的数字在道和降低的基因表示 cytokeratin 铺平的门附近证实的卵形的房间反应,这被发现 19 (CK19 ) 在对待 gliotoxin 的肝。这些数据提供激活的 HSC 涉及 hepatocyte 死亡和 hepatocytes 的增长,在 acetaminophen (APAP ) 的 HPC 导致了尖锐的肝损害的清楚的证据。 | Kuntang Shen Wenju Chang Xiaodong Gao Hongshan Wang Weixin Niu Lujun Song Xinyu Qin | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 13 |
| 2 | Isolation and culture of hepatic stellate cells from mouse liver显示文摘肝的星形的房间(HSC ) 是在肝以内的主要细胞外的生产矩阵的房间并且有众多的 vitalfunctions。为 HSC 的隔离和文化的一个柔韧的协议是重要的因为房间 functionsand 的进一步的调查在肝疾病联系了机制。鼠标肝的卷比老鼠肝的小得多,哪个对更困难的 makesit 比老鼠 HSC 孤立鼠标 HSC (mHSCs ) 。目前,孤立 mHSCs 仍然是挑战 becausethere 不是有效、柔韧的方法孤立并且文化这些房间。在现在的学习, C57BL/6J 老鼠是有包含 liposome 的 dichloromethylene diphosphate (CL2MDP ) 的 intravenouslyinjected 有选择地从 theliver 消除 Kupffer 房间。老鼠肝然后在 situ 被酒,并且 mHSCs 与一种优化密度坡度 centrifugation 技术被孤立。在磷酸盐缓冲区答案(PBS )-liposome 组, mHSCs 的收益是(1. | Wenj u Chang Mengxuan Yang Lujun Song Kuntang Shen Hongshan Wang Xiaodong Gao Min Li Weixin Niu Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 6 |
| 3 | Fabrication of(TiB/Ti)-TiAl composites with a controlled laminated architecture and enhanced mechanical properties显示文摘The(TiB/Ti)-TiAl composites with a laminated structure composing of alternating TiB/Ti composite layers,α_(2)-Ti_(3)Al interfacial reaction layers of andγ-TiAl layers were successfully pre pared by spark plasma sintering of alternately stacked Tib_(2)/Ti powder layers and TiAl powder layers.And the influence of thickness ratio of Tib_(2)/Ti powder layers to TiAl powder layers on microstructure evolution and mechanical properties of the re sulting(TiB/Ti)-TiAl laminated composites were investigated systemically.The results showed that the thickening ofα_(2)-Ti_(3)Al layers which originated from the reaction of Ti and TiAl was significantly hindered by introducing Tib_(2)particles into starting Ti powders.As the thickness ratio of Tib_(2)/Ti powder layers to TiAl powder layers increased,the bending fracture strength and fracture toughness at room temperature of the final(TiB/Ti)-TiAl laminated composites were remarkably improved,especially for the(TiB/Ti)-TiAl composites prepared by Tib_(2)/Ti powder layers with thickness of 800μm and TiAl powder layers with thickness of 400μm,whose fracture toughness and bending strength were up to 51.2 MPa·m^(1/2)and 1456 MPa,respectively,293%and 108%higher than that of the monolithic TiAl alloys in the present work.This was attributed to the addition of high-performance network TiB/Ti composite layers.Moreover,it was noteworthy that the ultimate tensile strength at 700℃of(TiB/Ti)-TiAl composites fabricated by 400μm thick Tib_(2)/Ti powder layers and 400μm thick TiAl powder layers was as high as that at 550℃of network TiB/Ti composites.This means the service temperature of(TiB/Ti)-TiAl laminated composites was likely raised by 150℃,meanwhile a good combination of high strength and high toughness at ambient tempe rature could be maintained.Finally,the fracture mechanism of(TiB/Ti)-TiAl laminated composites was proposed. | Hao Ding Xiping Cui Naonao Gao Yuan Sun Yuanyuan Zhang Lujun Huang Lin Geng | 2021 | Journal of Materials Science & Technology2021，，3： | 3 |
| 4 | Proliferation and differentiation potential of mouse adult hepatic progenitor cells cultured in vitro显示文摘,这研究试图孤立干细胞或祖先存在,从正常成年老鼠肝并且调查他们增长和区别的潜力。Hepatocytes 被修改二拍子的圆舞肝灌注方法和 centrifugation 孤立,然后在为观察的修改包含浆液的 DMEM 有教养超过 60 天。Immunofluorescence 技术被使用检查 hepatocytes 并且与白朊, -fetoprotein (法新社) 和 cytokeratin 检验殖民地的形成 19 (CK19 ) 。结果显示出为 hepatocyte 是强烈积极的那一些 hepatocytes 在文化的白天 1 上的特定的标记白朊,能在天被激活 23,由殖民地的快速的增长和形成列在后面。殖民地能不断地膨胀超过 60 天。在白天 5 上,在殖民地的所有房间表示了肝的干细胞(HSC ) 标记法新社。与文化的时间,在殖民地的一些房间失去了能力在天划分 1315,并且区分了进有大细胞质和大约二个原子核的房间,类似于成熟 hepatocytes 的外观词法上。这些区分的房间表明了白朊的强壮的表示。在白天 30 附近,一些大房间在殖民地出现了并且表示了胆汁管房间标记 CK19。因此,老鼠 hepatocytes 的这 subpopulation 能获得不成熟的 hepatocytes 的一些特征并且与区别的一个高增殖能力和双性人潜力显示出肝的祖先房间的侧面。他们从因此,成年人老鼠说出成年肝的祖先房间(AHPC ) 的正常被孤立。老鼠 AHPC 可以为 hepatocytes 移植和 hepatopathy 学习被用作一个 HSC 模型。 | Lujun Song Hongshan Wang Xiaodong Gao Kuntang Shen Weixin Niu Xinyu Qin | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 3 |
| 5 | Immunohistochemical expression of mTOR negatively correlates with PTENexpression in gastric carcinoma显示文摘 | Min Li Huawen Sun Lujun Song Xiaodong Gao Wenju Chang Xinyu Qin | 2012 | Oncology Letters2012，，6： | 2 |
| 6 | Striatal extracts promote the dopaminergic differentiation of GFP-bone mesenchymal stem cells显示文摘 | Shuhua Yang Qing Gao Lihua Bao Jing Zhang Yanlai Hu Lujun Bing Jinlong Sun Jing Hao Chao Chen Shangzhi Li W.S. Poon Jinhao Sun Yingmao Gao | 2012 | Neuroscience Letters2012，，2： | 2 |
| 7 | Isobaric vapor–liquid equilibrium for ternary system of ethanol, ethyl propionate and para-xylene at 101.3 kPa显示文摘Isobaric vapor–liquid equilibrium(VLE) data for the binary system ethyl propionate(2) + para-xylene(3) and ternary system ethanol(1) + ethyl propionate(2) + para-xylene(2) at atmospheric pressure(101.3 k Pa)were obtained by a VLE modified othmer still. All the experimental data passed a point to point consistency test of Van Ness method, which verified the data reliability. The Wilson and UNIQUAC activity coefficient models were employed to correlate the binary VLE data to obtain binary interaction parameters. Based on binary interaction parameters, ternary VLE data of ethanol(1) + ethyl propionate(2) + para-xylene(3) were predicted by Wilson and UNIQUAC models, which proved that predicted values are consistent with the experimental data.Furthermore, azeotropic phenomenon between ethanol and ethyl propionate disappears when the mole ratio of para-xylene and binary system of ethanol and ethyl propionate is 1:1. Therefore, this paper convinced that para-xylene is a proper extractive additive that could be used in extractive distillation to separate the binary azeotropic system of ethanol and ethyl propionate. | Zhongpeng Xing Yujie Gao Hui Ding Xianqin Wang Lujun Li Hang Zhou | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 1 |
| 8 | Transplantation of bone marrow derived cells promotes pancreatic islet repair in diabetic mice显示文摘 | Xiaodong Gao Lujun Song Kuntang Shen Hongshan Wang Weixin Niu Xinyu Qin | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 1 |
| 9 | Interfacial reaction mechanism of TiBw/Ti6Al4V composites and Inconel 718 alloys by GTAW heat transmission显示文摘A good joint of Ti Bw/Ti6Al4V composites and Inconel 718 alloys was obtained by Gas Tungsten Arc Welding(GTAW) heat transmission. The interfacial reaction mechanism of joint was investigated and analyzed in details. Owing to the heat input applied on the surface of Ti Bw/Ti6Al4V composites, a solid-state reaction layer appeared at the interface of Ti Bw/Ti6Al4 V composites to Inconel 718 alloys. The thickness of the reaction layer was obviously increased with increasing heat input.Developing of reaction layer mainly depended on the diffusion of elements of Ti and Ni through the interface during welding to form solid solutions and intermetallic compounds(IMCs). The reaction layer can be divided into Ti-rich zone(layer 2) and Nirich zone(layer 1). In Ni-rich zone, relatively coarse dendrites were the predominant, however, more brittle IMCs like Ti2Ni were found in the Ti-rich zone. Micro hardness of reaction layer was much higher than that of base metal. While a slight decrease of hardness was found between Ti-rich zone and Ni-rich zone due to the formation of TiNi. | GAO YaNan HUANG LuJun SUN Yuan AN Qi ZHANG Jie GENG Lin | 2019 | Science China(Technological Sciences)2019，62，12： | 1 |
| 10 | Transplantation of bone marrow derived cells promotes pancreatic islet repair in diabetic mice 显示文摘 | Gao Xiaodong Song Lujun Shen Kuntang | 2008 | Biochem Biophys Res Commun2008，371，： | 1 |
| 11 | Revealing the dominant factor of domain boundary resistance on bulk conductivity in lanthanum lithium titanates显示文摘Perovskite-type lithium lanthanum titanates(LLTO)display a high bulk ionic conductivity and are considered a promising electrolyte for building up to advanced solid-state Li-ion batteries.The LLTO crystals contain a high concentration of intrinsically formed 90ο-rotated domain boundaries(DBs)serving as barriers to bulk Li-ion conduction.However,the mechanism of how the DB concentration and DB resistance can compete with each other to determine the bulk conductivity of LLTO is still unknown.Here we report a comprehensive study of LLTO compounds,aimed to unravel the mechanism and hence explore new path(s)for further improving the conductivity of this material.Our results show that both the sintering temperature and chemical composition can affect significantly the domain structures in LLTO.It is found that a decrease in the DB concentration is always accompanied by increased DB resistance due to the increased lattice mismatch at DBs,and vice versa.By unifying the electrochemical impedance spectroscopy and transmission electron microscopy analysis,it is clearly shown that the high DB resistance,instead of DB concentration,acts as the dominant factor governing the bulk conductivity of LLTO.The results thus renew the conventional understanding of the bulk Li-ion conduction in LLTO and shed light on developing novel LLTO electrolyte materials with improved ionic conductivity. | Xuefeng Zhou Cong Gao Dandan Wang Shang Peng Lujun Huang Wenge Yang Wen-Hua Zhang Xiang Gao | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 12 | 8-Oxoguanine DNA glycosylase protects cells from senescence via the p53-p21 pathway显示文摘Cellular senescence is an important factor leading to pulmonary fibrosis.Deficiency of 8-oxoguanine DNA glyco-sylase(OGG1)in mice leads to alleviation of bleomycin(BLM)-induced mouse pulmonary fibrosis,and inhibition of the OGG1 enzyme reduces the epithelial mesenchymal transition(EMT)in lung cells.In the present study,we find decreased expression of OGG1 in aged mice and BLM-induced cell senescence.In addition,a decrease in OGG1 expression results in cell senescence,such as increases in the percentage of SA-β-gal-positive cells,and in the p21 and p-H2AX protein levels in response to BLM in lung cells.Furthermore,OGG1 promotes cell transformation in A549 cells in the presence of BLM.We also find that OGG1 siRNA impedes cell cycle progression and inhibits the levels of telomerase reverse transcriptase(TERT)and LaminB1 in BLM-treated lung cells.The increase in OGG1 expression results in the opposite phenomenon.The mRNA levels of senescence-associated secretory phenotype(SASP)components,including IL-1α,IL-1β,IL-6,IL-8,CXCL1/CXCL2,and MMP-3,in the absence of OGG1 are obviously increased in A549 cells treated with BLM.Interestingly,we demonstrate that OGG1 binds to p53 to inhibit the activation of p53 and that silencing of p53 reverses the inhibition of OGG1 on senescence in lung cells.Ad-ditionally,the augmented cell senescence is shown in vivo in OGG1-deficient mice.Overall,we provide direct evidence in vivo and in vitro that OGG1 plays an important role in protecting tissue cells against aging associated withthep53pathway. | Shenglan Gao Lujun Chen Ziying Lin Zhiliang Xu Yahong Wang Huayu Ling Zijun Wu Yu Yin Weimin Yao Keng Wu Gang Liu | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 13 | Geological Settings and Significance of Zigong Global Geopark显示文摘This paper introduced fossil resources,geographical settings and significance of Zigong Global Geopark.In addition,in the long history of local well salt production,remarkable ten great science and technology inventions were created,and numerous well salt production relics were perfectly preserved,thus they have high scientific value and significance.On the basis of field survey and detailed researches,the authors analyzed geological settings in the geopark and significance in depth.The results deduced by the authors can help understand the geoheritage resources in Zigong Global Geopark,and also provide a basis for the protection,development and utilization of geoheritage as well as the planning and management of the geopark. | YOU Yuning TIAN Mingzhong GAO Lujun | 2013 | Journal of Landscape Research2013，5，9： | 0 |
| 14 | Enhancing reversibility of LiNi_(0.5)Mn_(1.5)O_(4)by regulating surface oxygen deficiency显示文摘Oxygen deficiency has crucial effects on the crystal structure and electrochemical performance of spinel oxide lithium electrode materials such as LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)cathode.In particular,the oxygen stoichiometry on the crystal surface differs from that on the crystal interior in LNMO.The detection of local oxygen loss in LNMO and its correlation with the crystal structure and the cycling stability of LNMO remain challenging.In this study,the effect of oxygen deficiency in LNMO controlled by sintering temperature on the surface crystal structure and electrochemical performance of LNMO is comprehensively investigated.The high concentration of oxygen vacancies segregates at the surface regions of LNMO forming a thin rock‐salt and/or deficient spinel surface layer.The atomic‐level surface structure reconstruction was demonstrated by annular dark‐field and annular brightfield techniques.For the synthesis of LNMO,the higher sintering temperature results in higher crystallinity but the higher oxygen deficiency in LNMO.The high crystallinity of LNMO would increase the thermal stability of LNMO cathodes while the high content of oxygen deficiency would decrease the surface structural stability of LNMO.Therefore,the LNMO sintered at a medium temperature of 850°C achieved the best capacity retention.The results suggest a competitive function mechanism between oxygen stoichiometry and the crystallinity of LNMO on the cycling performance of LNMO. | Dandan Wang Cong Gao Xuefeng Zhou Shang Peng Mingxue Tang Yonggang Wang Lujun Huang Wenge Yang Xiang Gao | 2023 | Carbon Energy2023，5，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员