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| 1 | 基于计算试验设计与代理模型的飞行器近似优化策略探讨显示文摘现代飞行器设计优化中广泛应用高精度分析模型以提高设计可信度与综合性能,但是也带来了计算复杂性问题。为了有效缓解计算耗时的问题,基于计算试验设计与代理模型的飞行器近似优化策略成为研究热点。近似优化策略通过构造合理的近似模型引导优化过程快速收敛到最优解,从而达到降低计算成本,缩短设计周期的目的。根据广泛的文献调研,对飞行器近似优化策略的发展现状进行详细探讨。给出近似优化策略的定义、求解流程、特点以及关键技术。对计算试验设计方法、代理模型方法、精度校验与代理模型选择方法等技术进行综述。围绕静态与自适应两类近似优化策略,重点讨论典型的代理模型管理与更新策略与收敛准则。针对飞行器多学科设计优化问题,探讨近似优化策略与分解策略在求解效率与收敛性方面的技术特点。通过数值算例对各项关键技术的特点进行较详尽的对比分析与总结,并依托飞行器设计优化工程实例对近似优化策略的综合性能进行探讨,指出不同近似优化策略的适用范围。研究结果表明,飞行器近似优化策略在优化效率、全局收敛性以及鲁棒性等方面体现出较显著的优势,具有良好的工程应用前景。指出飞行器近似优化策略的未来研究方向。 | 龙腾 刘建 WANG G Gary 刘莉 史人赫 郭晓松 | 2016 | 机械工程学报2016，52，14： | 69 |
| 2 | 染色体异常与男性不育显示文摘不育问题惊人地困扰着15%想要组建新家庭的人群。尽管如此,不育的分子遗传因素大多还不清楚。不过,越来越多不育遗传因素正逐渐被发现。本综述主要讨论目前了解的男性不育的染色体因素,尤其是染色体非整倍体、染色体组型的结构和数量异常和Y染色体微缺失。染色体非整倍体是人类流产和发育残疾的主要原因。非整倍体主要起源于母体,但是人们正在关注单精子注射的安全性,因为不育男性的精子非整倍体水平明显比起配偶高。染色体组型结构和数量异常的男性产生非整倍体精子的风险也越来越高。本文还综述了精子非整倍体如何被翻译至胚胎非整倍体,以及植入前基因诊断在这些病例中的应用。如果可能,文章还会做一下临床方面的建议,并讨论一些新兴的阵列技术在植入前基因诊断中使用以及在男性不育的潜在应用。 | Gary L Harton Helen G Tempest | 2012 | Asian Journal of Andrology2012，14，1： | 25 |
| 3 | 基于信号质量评估和卡尔曼滤波的心率估计算法显示文摘目的:研究基于多导重症监护导联心电分析的逐搏心率估计算法。方法:通过开放源码的QRS搏动识别算法计算逐搏心率,通过分析信号的波形特征、统计特性和相互关系导出反映信号质量好坏的信号质量指数(signalqualityindex,SQI)。应用基于信号质量指数调节的卡尔曼滤波方法进行心率估计,通过残差值和信号质量指数的大小来动态调节卡尔曼滤波器的状态变量,获得逐搏心率的最佳估计。应用美国麻省理工学院多参数智能重症监护数据库II中437例病人的6000多小时高质量数据和人为添加真实心电干扰的数据进行算法评价。结果:与直接心率估计及采样保持等算法比较,本算法在严重干扰存在时,心率估计的均方根误差最小。结论:基于信号质量评估和卡尔曼滤波的心率估计算法在严重干扰存在时仍能提供精确的心率估计。 | 李桥 Roger G Mark Gari D Clifford 俞梦孙 | 2007 | 中国医学物理学杂志2007，24，6： | 8 |
| 4 | Physical rehabilitation for lung transplant candidates and recipients: An evidence-informed clinical approach显示文摘Physical rehabilitation of lung transplant candidates and recipients plays an important in optimizing physical function prior to transplant and facilitating recovery of function post-transplant. As medical and surgical interventions in lung transplantation have evolved over time, there has been a demographic shift of individuals undergoing lung transplantation including older individuals, those with multiple co-morbidites, and candidates with respiratory failure requiring bridging to transplantation. These changes have an impact on the rehabilitation needs of lung transplant candidates and recipients. This review provides a practical approach to rehabilitation based on research and clinical practice at our transplant centre. It focuses on functional assessment and exercise prescription during an uncomplicated and complicated clinical course in the pre-transplant, early and late post-transplant periods. The target audience includes clinicians involved in pre- and posttransplant patient care and rehabilitation researchers. | Lisa Wickerson Dmitry Rozenberg Tania Janaudis-Ferreira Robin Deliva Vincent Lo Gary Beauchamp Denise Helm Chaya Gottesman Polyana Mendes Luciana Vieira Margaret Herridge Lianne G Singer Sunita Mathur | 2016 | World Journal of Transplantation2016，6，3： | 8 |
| 5 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 6 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 7 | Hierarchical genetic algorithm for near-optimal feedforward neural network design 显示文摘 | YEN Gary G LU Hai-ming | 2002 | International Journal of Neural Systems2002，12，1： | 2 |
| 8 | 针对高维优化问题的快速追峰采样方法显示文摘基于计算试验设计和代理模型的近似优化策略在现代复杂系统工程设计中得到了广泛应用,其中追峰采样方法(Modepursuing sampling, MPS)是一种代表性的近似优化策略。分析并针对MPS处理高维优化问题时效率低下的缺陷,提出了基于重点设计空间的快速追峰采样方法(RMPS-SDS),将重点设计空间的思想引入MPS框架,定制了一套样本点分配策略以增强MPS的局部搜索能力与收敛速度,从而提高求解高维优化问题的效率。采用一系列标准数值测试问题和工程设计问题检验RMPS-SDS方法的性能,并与MPS和GA进行了对比研究。研究结果表明,在相同模型调用次数前提下,RMPS-SDS的优化结果更接近理论全局最优解,且鲁棒性更好。与标准MPS相比,RMPS-SDS方法求解高维优化问题的效率、收敛性和鲁棒性都具有明显优势,更具有工程实用性。 | 武宇飞 龙腾 史人赫 WANG G Gary | 2019 | 机械工程学报2019，55，3： | 2 |
| 9 | Cellular Motility Driven by Assembly and Disassembly of Actin Filaments显示文摘 | Thomas D Pollard Gary G Borisy | 2003 | Cell2003，，4： | 2 |
| 10 | Reliable Space Pursuing for Reliability-based Design Optimization with Black-box Performance Functions显示文摘Reliability-based design optimization(RBDO) is intrinsically a double-loop procedure since it involves an overall optimization and an iterative reliability assessment at each search point.Due to the double-loop procedure, the computational expense of RBDO is normally very high.Current RBDO research focuses on problems with explicitly expressed performance functions and readily available gradients.This paper addresses a more challenging type of RBDO problem in which the performance functions are computation intensive.These computation intensive functions are often considered as a'black-box'and their gradients are not available or not reliable.On the basis of the reliable design space(RDS) concept proposed earlier by the authors, this paper proposes a Reliable Space Pursuing(RSP) approach, in which RDS is first identified and then gradually refined while optimization is performed.It fundamentally avoids the nested optimization and probabilistic assessment loop.Three well known RBDO problems from the literature are used for testing and demonstrating the effectiveness of the proposed RSP method. | SHAN Songqing WANG G Gary | 2009 | Chinese Journal of Mechanical Engineering2009，22，1： | 2 |
| 11 | 膳食脂肪和心脏代谢健康:证据、争议和指导共识显示文摘Nita G Forouhi及其同事认为,尽管在营养研究和制定指南方面存在困难,但公众越来越能理解膳食脂肪和整体饮食的复杂性。 | Nita G Forouhi Ronald M Krauss Gary Taubes Walter Willett 仲琳(译) 王春筱(译) 杨军(校) | 2021 | 英国医学杂志中文版2021，24，3： | 2 |
| 12 | Effective- ness of Grass Strips to Filter Catfish Pond Effluent 显示文摘 | Ghate S R Gary J Burtle George Vellidis G Larry Newton | 1997 | Aquacultural Engineering1997，16，： | 2 |
| 13 | Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage显示文摘AIM:To evaluate whether desferrioxamine decreases ischemia and perfusion injury aggravated by cold storage(CS)in a rat liver perfusion model. METHODS:Isolated rat livers were kept in CS in University of Wisconsin Solution for 20 h at 4℃,then exposed to 25 min of warm ischemia(WI)at 37℃ followed by 2 h of warm perfusion(WP)at 37℃with oxygenated(95%oxygen and 5%carbon dioxide) Krebs-Henseleit buffer.Desferrioxamine(DFO),an iron chelator,was added at different stages of storage,ischemia and perfusion:in CS only,in WI only,in WP only, in WI and perfusion,or in all stages.Effluent samples were collected after CS and after WI.Perfusate samples and bile were collected every 30 min(0,0.5,1,1.5 and 2 h)during liver perfusion.Cellular injury was assessed by the determination of lactate dehydrogenase(LDH) and aspartate aminotransferase(AST)in the effluent and perfusate samples.Total iron was analysed in the perfusate samples.After WP,the liver was collected for the determination of liver swelling(wet to dry ratio) and liver morphological examination(hematoxylin and eosin staining). RESULTS:Increased CS time caused increased liver dysfunction during WP.After 2 h of WP,liver injury was indicated by increased release of AST(0.5 h CS:9.4± 2.2 U/g liver vs 20 h CS:45.9±10.8 U/g liver,P<0.05) and LDH(0.5 h CS:59±14 U/g liver vs 20 h CS:297 ±71 U/g liver,P<0.05).There was an associated increase in iron release into the perfusate(0.5 h CS:0.11 ±0.03μmoL/g liver vs 20 h CS:0.58±0.10μmoL/g liver,P<0.05)and reduction in bile flow(0.5 h CS: 194±12μL/g vs 20 h CS:71±8μL/g liver,P<0.05). When DFO was added during WI and WP following 20 h of CS,release of iron into the perfusate was de- creased(DFO absent 0.58±0.10μmoL/g liver vs DFO present 0.31±0.06μmoL/g liver,P<0.05),and liver function substantially improved with decreased release of AST(DFO absent 45.9±10.8 U/g liver vs DFO present 8.1±0.9 U/g liver,P<0.05)and LDH(DFO absent 297±71 U/g liver vs DFO present 56±7 U/g liver,P<0.05),and increased bile flow(DFO absent 71±8μL/g liver vs DFO present 237±36μL/g liver, P<0.05).DFO was also shown to improve liver morphology after WP.Cellular injury(the release of LDH and AST)was significantly reduced with the addition of DFO in CS medium but to a lesser extent compared to the addition of DFO in WP or WI and perfusion.There was no effect on liver swelling or bile flow when DFO was only added to the CS medium. CONCLUSION:DFO added during WI and perfusion decreased liver perfusion injury aggravated by extended CS. | Peter G Arthur Xian-Wa Niu Wen-Hua Huang Bastiaan DeBoer Ching Tat Lai Enrico Rossi John Joseph Gary P Jeffrey | 2013 | World Journal of Gastroenterology2013，19，5： | 2 |
| 14 | Enhanced Offset Averaging Technique for Flash ADC Design显示文摘This paper presents a new combined AC/DC-coupled output averaging technique for input amplifier design of flash analog-to-digital converters (ADC). The new offset averaging design technique takes full advantage of traditional DC-coupled resistance averaging and AC-coupled capacitance averaging techniques to minimize offset-induced ADC nonlinearities. Circuit analysis allows selection of optimum resistance and capacitance averaging factors to achieve maximum offset reduction in ADC designs. The new averaging method is verified in designing a 4 bit 1 Gs/s flash ADC that is implemented in foundry 0.13 μm CMOS technology. | Siqiang FAN He TANG Hui ZHAO Xin WANG Albert WANG Bin ZHAO Gary G ZHANG | 2011 | Tsinghua Science and Technology2011，16，3： | 2 |
| 15 | Returns to research and development in Chinese industry:Evidence from state-owned enterprises in Beijing显示文摘 | ALBERT G HU GARY H J | 2004 | China Economic Review2004，15，1： | 1 |
| 16 | Housing wealth,fi-nancial wealth,and consumption:New evidence from microdata显示文摘 | Raphael B Stuart G Gary P | 2009 | Regional Science and Urban Economics2009，，： | 1 |
| 17 | Evaluation of stress–strain curve estimates in dynamic experiments显示文摘 | Dirk Mohr Gérard Gary Bengt Lundberg | 2009 | International Journal of Impact Engineering2009，，2： | 1 |
| 18 | Paleoshoreline evidence for postglacial tilting in Southern Manitoba显示文摘 | Gary E T Donald R C Bruce G B | 1998 | Journal of Paleolin- nology1998，19，： | 1 |
| 19 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 20 | On the Use of SHPB Techniques Techniques to Determine the Dynamic Behavior of Materials in the Range of Small Strains显示文摘 | Zhao H Gary G | 1996 | Internation of journal of Solid and Structures1996，33，23： | 1 |
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