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| 1 | Morinda citrifolia (Noni): A literature review and recent advances in Noni research^1显示文摘Morinda citrifolia L(Noni) has been used in folk remedies by Polynesians for over 2000 years,and is reported to have a broad range of therapeutic effects,including antibacterial,antiviral,antifungal,antitumor,antihelmin,analgesic,hypotensive,anti-inflammatory,and immune enhancing effects.In order to reveal the nutritional and medicinal value of the Noni plant,and to summarize scientific evidence that supports the Polynesians' claim,a literature review and recent advances in Noni research is given below. | Brett J WEST CJarakae JENSEN Diane NOWICKI SU Chen Afa K PALU Gary ANDERSON | 2002 | Acta Pharmacologica Sinica2002,23,12: | 80 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020,23,9: | 5 |
| 3 | Living high training low induces physiological cardiac hypertrophy accompanied by down-regulation and redistribution of the renin-angiotensin system显示文摘 | Wei SHI J Gary MESZAROS Shao-ju ZENG Ying-yu SUN Ming-xue ZUO | 2013 | Acta Pharmacologica Sinica2013,34,3: | 4 |
| 4 | Laser-induced microjet-assisted ablation for high-quality microfabrication显示文摘Liquid-assisted laser ablation has the advantage of relieving thermal effects of common laser ablation processes, whereas the light scattering and shielding effects by laser-induced cavitation bubbles, suspended debris, and turbulent liquid flow generally deteriorate laser beam transmission stability, leading to low energy efficiency and poor surface quality. Here, we report that a continuous and directional high-speed microjet will form in the laser ablation zone if laser-induced primary cavitation bubbles asymmetrically collapse sequentially near the air-liquid interface under a critical thin liquid layer. The laser-induced microjet can instantaneously and directionally remove secondary bubbles and ablation debris around the laser ablation region, and thus a very stable material removal process can be obtained. The shadowgraphs of high-speed camera reveal that the average speed of laser-induced continuous microjet can be as high as 1.1 m sin its initial 500 μm displacement. The coupling effect of laser ablation, mechanical impact along with the collapse of cavitation bubbles and flushing of high-speed microjet helps achieve a high material removal rate and significantly improved surface quality. We name this uncovered liquid-assisted laser ablation process as laser-induced microjet-assisted ablation(LIMJAA) based on its unique characteristics. High-quality microgrooves with a large depth-to-width ratio of 5.2 are obtained by LIMJAA with a single-pass laser scanning process in our experiments. LIMJAA is capable of machining various types of difficult-to-process materials with high-quality arrays of micro-channels, square and circle microscale through-holes. The results and disclosed mechanisms in our work provide a deep understanding of the role of laser-induced microjet in improving the processing quality of liquid-assisted laser micromachining. | Yang Guo Pei Qiu Shaolin Xu Gary J Cheng | 2022 | International Journal of Extreme Manufacturing2022,4,3: | 3 |
| 5 | A review on microstructures and properties of high entropy alloys manufactured by selective laser melting显示文摘High entropy alloys(HEAs)with multi-component solid solution microstructures have the potential for large-scale industrial applications due to their excellent mechanical and functional properties.However,the mechanical properties of HEAs limit the selection of processing technologies.Additive manufacturing technology possesses strong processing adaptability,making itthe best candidate method to overcome this issue.This comprehensive review examines the current state of selective laser melting(SLM)of HEAs.Introducing SLM to HEAs processing is motivated by its high quality for dimensional accuracy,geometric complexity,surface roughness,and microstructure.This review focuses on analyzing the current developments and challenges in SLM of HEAs,including defects,microstructures,and properties,as well as strengthing prediction models of fabricated HEAs.This review also offers directions for future studies to address existing challenges and promote technological advancement. | Chen Zhang Junkai Zhu Huai Zheng Hui Li Sheng Liu Gary J Cheng | 2020 | International Journal of Extreme Manufacturing2020,2,3: | 3 |
| 6 | Transanal total mesorectal excision:a valid option for rectal cancer?显示文摘Low anterior resection can be a challenging operation, especially in obese male patients and in particular after radiotherapy. Transanal total mesorectal excision(Ta TME) might offer technical advantages over laparoscopic or open approaches particularly for tumors in the distal third of the rectum. The aim of this article is to review the current experience with Ta TME. The limits and future developments are also explored. Although the experience with Ta TME is still limited, it might be a promising alternative to laparoscopic TME, especially for difficult cases where laparoscopy is too demanding. The preliminary data on complications and short-term oncological outcomes are good, but also emphasize the importance of careful patient selection. Finally, there is a need for large-scale trials focusing on long-term outcomes and oncological safety before widespread adoption can be recommended. | Nicolas C Buchs Gary A Nicholson Frederic Ris Neil J Mortensen Roel Hompes | 2015 | World Journal of Gastroenterology2015,21,41: | 3 |
| 7 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003,,1: | 2 |
| 8 | Tuberculosis显示文摘 | Gary Maartens Robert J Wilkinson | 2007 | The Lancet2007,,9604: | 2 |
| 9 | Endogenous testosterone and mortality risk显示文摘在人,肥胖和新陈代谢的复杂并发症与更低的浆液睾丸激素被联系(T) 和 dihydrotestosterone 和增加的风险,和死亡从(DHT ) ,除了心血管的疾病(CVD ) 的多重长期的疾病。在这些因素之间的原因的相互关系仍然是争论的一件事。在有 hypogonadotropic 性腺机能减退的未经治疗的先天、终生的形式的人,看起来不是增加的风险。有 Klinefelters 症候群的人有癌症,以及 CVD 的各种各样的类型的增加的风险,尽管有 T,它坚持治疗。当 hypothalamic-pituitary-gonadal 轴的病理不在时,在在使人变老的浆液 T 的谦虚减小的效果是不清楚的。低浆液 T 集中的流行在有癌症,肾的疾病,和呼吸疾病的人高并且是可能的是全身的疾病,不是性腺机能减退的严厉的指示物。一些基于人口的研究发现了低浆液 T 与归因于癌症,肾的疾病,和呼吸疾病的死亡的更高的风险被联系,当其它没有时。尽管纵的研究的元分析显示出在低浆液 T 和所有原因死亡之间的一个协会,在研究之间的显著异质限制了一个坚挺的结论。因此,当在以后特别地发生在生活的 T 的减少可以与人的所有原因和死亡的特定的类型的增加被联系时,如果有的话,微分效果作为与健康和生活方式因素相比 T 和另外的性别类固醇是未知的在当前的时间。 | Emily J Meye Gary Wittert | 2018 | Asian Journal of Andrology2018,20,2: | 2 |
| 10 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007,,: | 2 |
| 11 | 细胞内蛋白质磁共振(英文)显示文摘细胞内的环境异常复杂,其中生物大分子的浓度超过300mg/mL并占据着大约30%的细胞内空间.然而,直到目前为止大多数的蛋白质研究仍然在细胞外或是甚至非常稀的缓冲液中进行.细胞内磁共振(In-cell NMR)提供了一个可以直接非损伤地获取细胞内原子水平信息的方法.虽然In-cell NMR在近10年里有了较大的发展,但是这一技术尚未成熟.在该篇综述中,作者首先总结制约这一技术发展的因素以及研究中需要注意的事项,最后讨论了未来的发展方向. | 王亚强 李从刚 PIELAK Gary J | 2012 | 波谱学杂志2012,29,4: | 2 |
| 12 | Autophagy regulates adipose mass and differentiation in mice显示文摘 | Singh Rajat Xiang Youqing Wang Yongjun Baikati Kiran Cuervo Ana Maria Luu Yen K Tang Yan Pessin Jeffrey E Schwartz Gary J Czaja Mark J | 2009 | Journal of Clinical Investigation2009,,11: | 2 |
| 13 | Predictors of progression in Barrett’s esophagus III: baseline flow cytometric variables显示文摘 | Peter S Rabinovitch Gary Longton Patricia L Blount Douglas S Levine Brian J Reid | 2001 | The American Journal of Gastroenterology2001,,11: | 2 |
| 14 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001,,10: | 2 |
| 15 | Effective- ness of Grass Strips to Filter Catfish Pond Effluent 显示文摘 | Ghate S R Gary J Burtle George Vellidis G Larry Newton | 1997 | Aquacultural Engineering1997,16,: | 2 |
| 16 | Laser in situ keratomileusis for myopia and astigmatism: safety and efficacy显示文摘 | Alan Sugar Christopher J Rapuano William W Culbertson David Huang Gary A Varley Peter J Agapitos Vincent P de Luise Douglas D Koch | 2002 | Ophthalmology2002,,1: | 2 |
| 17 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013,,1: | 2 |
| 18 | Returns to research and development in Chinese industry:Evidence from state-owned enterprises in Beijing显示文摘 | ALBERT G HU GARY H J | 2004 | China Economic Review2004,15,1: | 1 |
| 19 | Marked improvement of PAC and BAG cloning is achieved using electroelution of pulsed-field gelseperated partial digested of genomic DNA显示文摘 | Scott J S Yuko O Gary W L | 1997 | Nucleic Acids Res1997,25,: | 1 |
| 20 | Reproductive strategy and population variability in the facultative apomict Hieracium llosella(Asteraceae) 显示文摘 | GARY J HOULISTON HAZEL M | 2001 | American Journal of Botany2001,88,6: | 1 |