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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Physical Properties of Polymer/clay Nanocomposites显示文摘 | Clois E Powell Gary W Beall | 2006 | Current Opinion in Solid State and Materials Science2006，0，： | 1 |
| 3 | Harmonic diffractive lenses 显示文摘 | DONALD W S GARY E S | 1995 | Appl Opt1995，34，： | 1 |
| 4 | Besifloxacin,a novel fluoroquinolone,has broad-spectrum in vitro activity against aerobic and anaerobic bacteria显示文摘 | Haas W Chris M P Gary E Z | 2009 | Antimicrob Agents Chemother2009，53，8： | 1 |
| 5 | Quaternary methyl carbonates: novel agents for fabric conditioning 显示文摘 | Gary W Earl Duane E Weisshaar | 2004 | Surfactants and Detergents2004，8，4： | 1 |
| 6 | Modelling recreation demand using choice experiments: Climbing in Scotland 显示文摘 | Hanley N Robert E W Gary K | 2002 | Environmental and Resource Economics2002，22，： | 1 |
| 7 | High temperature lead-free solder for microelectronics 显示文摘 | Framl W Gau e Gary Becka Jerry Badgett | 2001 | J Electron Mater2001，，6： | 1 |
| 8 | Knowledge sharing in high technology companies显示文摘 | Inger V E Gary W D | 2000 | Journal of Marketing2000，48，： | 1 |
| 9 | Framework for multidisciplinary integrated modelling and analysis of space telescopes显示文摘 | Alivier L W Gary E M | 2002 | Integrated Modeling of Telescopes2002，，： | 1 |
| 10 | XPS and FTIR surface characterization of TiO2 particles used in polymer encapsulation显示文摘 | Bedri E Robert A H Gary W S | 2001 | Langmuir2001，17，： | 1 |
| 11 | Genetic algorithm-based method for selecting wavelengths and model size for use with partial least-squares regression:Application to near-infrared spectroscopy显示文摘 | Bangalore Arjun S Shaffer Ronald E Small Gary W | 1996 | Analytical Chemistry1996，68，23： | 1 |
| 12 | Board structure, ownership, and financial distress in banking firms 显示文摘 | Gary Simpson W Anne E Gleason | 1999 | International Review of Economics and Finance1999，，8： | 1 |
| 13 | Free fatty acid induced insulin resistance is associated with activation of protein kinase C and alterations in the insulin signaling cascade显示文摘 | Griffin M E Marcucci M J Gary W | 1999 | DIABETES1999，48，： | 1 |
| 14 | Electrically Conductive Polymer Composites: Polymerization of Acetylene in Polyethylene 显示文摘 | Mary E G Gary E W | 1982 | Poly -mercomm1982，，6： | 1 |
| 15 | Harmonic diffractive lenses显示文摘 | DONALD W S GARY E S | 1995 | Appl Opt1995，34，： | 1 |
| 16 | Meta-Raps approach for the 0-1 Multidimensional Knapsack Problem显示文摘 | Reinaldo J M Gail W D Gary E | 2005 | Computers & Industrial Engineering2005，48，1： | 1 |
| 17 | Optical multlplay- er films based on an amorphous fluoropolymer显示文摘 | ROBERT C GARY E L RAYMOD L W | 1996 | Vacuum Science1996，14，1： | 1 |
| 18 | An effective and simple heuristic for the set covering problem 显示文摘 | Lan Guang-hui Gall W DePuy Gary E Whitehouse | 2007 | European Journal of Operational Research2007，176，1： | 1 |
| 19 | C-peptide reverses TGF- 13 1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy显示文摘 | CLAIRE E H GARY B W NIGEL J B | 2009 | Am J Physiol Renal Physiol2009，296，3： | 1 |
| 20 | An Effective and Simple Heuristic for the Set Covering Problem 显示文摘 | LAN GUANGHUI DEPUY GAIL W WHITEHOUSE GARY E | 2007 | European Journal of Operational Research2007，176，3： | 1 |
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