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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | The expression of Fhit protein is related Inversely to disease progression on inpa- tients with breast carcinoma 显示文摘 | Gatalica Z Lele SM Rampy BA' | 2000 | Cancer2000，88，6： | 1 |
| 3 | The expression of FHIT protein is related inversely to disease progression in patient with breast carcinoma显示文摘 | GATALICA Z LELE S M RAMPY B A | 2000 | Cancer2000，88，6： | 1 |
| 4 | ER-a36, a novel iso- form of ER-ct66, is commonly ovER-expressed in apocrine and adenoid cystic carcinomas of the breast 显示文摘 | Vranic S Gatalica Z Deng H | 2011 | J Clin Patho12011，1，： | 1 |
| 5 | MMP13 pro- moter polymorphism is associated with atherosclerosis in the ab- dominal aorta of young black males 显示文摘 | YOON S KUIVANIEMI H GATALICA Z | 2002 | Matrix Biol2002，21，6： | 1 |
| 6 | The expression of FHIT protein is related inversely to disease progression on inpatients with breast carcinoma显示文摘 | Gatalica Z Lele SM Rampy BA | 2000 | Cancer2000，88，6： | 1 |
| 7 | The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma显示文摘 | Gatalica Z Lele SM Rampy BA | 2000 | Cancer2000，88，6： | 1 |
| 8 | The expression of Fhit protein is related inversely to disease progression in patient with breast carcinoma显示文摘 | Gatalica Z Ide S M Rampy B A | 2000 | Cancer2000，88，6： | 1 |
| 9 | The expression of fhit protein is related inversely to disease progression in patients with breast carcinoma显示文摘 | Gatalica Z Lele SM Rampy BA | 2000 | Cancer2000，88，6： | 1 |
| 10 | The expression of Fhit protein is related inversely to disease progressionin patients with breast carcinoma显示文摘 | GATALICA Z LELE S M RAMPY B A | 2000 | Cancer2000，88，6： | 1 |
| 11 | Immunohistochemical analysis of steroid Hormone receptors in nasopharyngeal angiofibromas 显示文摘 | Gatalica Z | 1998 | Cancer Let1998，127，1： | 1 |
| 12 | IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection显示文摘 | Haeberle H A Casola A Gatalica Z | 2004 | J Virl2004，78，5： | 1 |
| 13 | The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma显示文摘 | Gatalicae Z Lele SM Rampy BA | 2000 | Cancer2000，88，6： | 1 |
| 14 | Syk tyrosine kinase expression during multistep mammary carcinogenesis显示文摘 | Gatalica Z Bing Z | 2005 | Croat Med J2005，46，3： | 1 |
| 15 | The expression of Fhit protein is related inversely to disease progression in patientswitb breast carcinoma显示文摘 | Gatalica Z Lele SM Rampy BA | 2000 | Cancer2000，88，6： | 1 |
| 16 | Syk tyrosine kinase expression during multistep mammary carcinogenesis显示文摘 | Gatalica Z B ing Z | 2005 | Croat Med j2005，46，3： | 1 |
| 17 | The expression of FHIT protein is related inversely to disease progression on inpatients with breast carcinoma 显示文摘 | Gatalica Z Lele SM Rampy BA | 2000 | Cancer2000，88，6： | 1 |
| 18 | ER-alpha36, a novel isoformof ER-alpha66, is commonly over-expressed in apocrine andadenoid cystic carcinomas of the breast显示文摘 | Vranic S Gatalica Z Deng H | 2011 | J Clin Pathol2011，64，1： | 1 |
| 19 | P53 protein expression and gene mutation in phyllodes tumors of the breast 显示文摘 | Gatalica Z Finkelstein S Lucio E | 2001 | Parbol Res Praet2001，197，3： | 1 |
| 20 | MMP13 promoter polymorphism is associated with atherosclerosis in the abdominal aorta of young black males显示文摘 | Yoon S Kuivaniemi H Gatalica Z | 2002 | Matrix Biol2002，21，6： | 1 |
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