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| 1 | 大亚湾海域多溴联苯醚的生物累积特征显示文摘于2003年9月在大亚湾海域采集生物(鱼、虾、蟹和乌贼)样品,分析其多溴联苯醚(PBDEs)的浓度和脂含量,以及同位素δ15N与δ13C的值.结果表明,鱼、虾、蟹和乌贼的PBDEs总平均含量分别为5.43±3.97,1.18±0.67,3.37±2.33,5.66ng/g脂重.肉食性的鱼类PBDEs的生物累积比植食性的鱼类相对较高.BDE47为最优势组分,占总PBDEs的30%,且在所有样品中均被检出.生物体中PBDEs的含量与脂含量和δ15N值均呈正相关,脂含量对生物体富集PBDEs的影响远比生物所处的营养级的影响大. | 丘耀文 张干 郭玲利 Zheng Gene J 李向东 李军 刘向 | 2006 | 中国环境科学2006，26，6： | 17 |
| 2 | 深圳湾海域多溴联苯醚(PBDEs)生物累积及其高分辨沉积记录显示文摘深圳湾,毗邻香港,是深圳经济特区的重要经济发展和生态调节区域。为了更好地了解该湾多溴联苯醚(PBDEs)的生物累积规律及其污染历史,作者采集该海域19个鱼、2个虾、2个蟹和柱状沉积物样品,分析其中PBDE的组分与含量,以及生物体的δ15N同位素、总脂含量和柱状沉积物的沉积年龄(210Pb)、总有机碳(TOC)。结果表明,深圳湾海域鱼类Σ15PBDEs组分的残余量为21—167ng/glw(或0.17—4.16ng/gfw),平均为(67±42)ng/glw或(2.00±1.14)ng/gfw,其含量与生物体的δ15N同位素和脂含量正相关,BDE-47、BDE-100为生物体中PBDE最优势组分且在所有生物样品中均检出,分别占46.5%、13.5%,肉食性的鱼类较植食性的鱼类PBDEs的生物累积总体上较高。柱状沉积物中Σ22PBDEs含量(0.07—4.85ng/gdw)近二十几年来有明显的上升趋势,平均沉积通量为0.25ng/(cm2·a),丰度最高的PBDE组分为BDE-47、BDE-49、BDE-99、BDE-183(不包括BDE-209);PBDEs在生物体和柱状沉积物中的含量位于全球PBDEs含量的中低端范围;鱼类等生物体中PBDE的生物-沉积物累积比值(BSAF)比值(<0.8)较小,与相应的PBDE的log KOW(辛醇/水分配比)存在一定的正相关性。 | 丘耀文 张干 郭玲利 Gene J Zheng 李军 刘向 | 2009 | 海洋与湖沼2009，40，3： | 15 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Polybrominated diphenyl e- thers (PBDEs) in sediments and mussel tissues from Hong Kong marine waters 显示文摘 | LIU Y GENE J Y YU H X | 2005 | Marine Pollution Bulletin2005，50，11： | 1 |
| 5 | Persistent toxic substances in remote lake and coastal sediments from Svalbard, Norwegian Arctic: levels, sources and fluxes 显示文摘 | Liping Jiao Gene J Zheng Tu Binh Minh | 2009 | Environmental Pollution2009，157，： | 1 |
| 6 | Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiat into astrocytes after injection into neonatal mouse brains 显示文摘 | Kopen Darwin J | 1999 | Proc Natl Acad Sci1999，96，10： | 1 |
| 7 | What is the best strategy for diagosis and treatment of Helicobacter pylori in the prevention of recurrent peptic ulcer bleeding?A cost-effectiveness analysis显示文摘 | Gene E Sanchez-Delgado J Calvet X | 2009 | Value Health2009，12，5： | 1 |
| 8 | The Relation Between NOx Emissions and Precipitation NO3-in the Eastern USA显示文摘 | Thomas J B Gene L Francoise M | 2003 | Atmospheric Environment2003，37，： | 1 |
| 9 | Enhancement of LTP in aged rats is dependent on endogenous BDNF显示文摘 | Diógenes M J Costenla A R Lopes L V | 2011 | Neuropsychopharmacology2011，36，9： | 1 |
| 10 | Public participation methods:A framework for evaluation显示文摘 | Rowe Gene Lynn J Frewer | 2000 | Science Technology & Human Value2000，18，3： | 1 |
| 11 | Developments in fungal taxonomy 显示文摘 | GUARRO J GENE J ALBEOM | 1999 | Clinical Microbiology Reviews1999，12，4： | 1 |
| 12 | Molecular and morphological identification of Colletotrichum species of clinical interest 显示文摘 | Cano J Guarro J Gene J | 2004 | Journal of Clinical Microbiology2004，42，6： | 1 |
| 13 | PCC7002 显示文摘 | Sakmoto T Higashi S C Wada H J et aLLow-temperature- induced desaturation of fatty acid sandex pression of desaturase genes in the Cyanobacterium Synechocoeeus sp | 1997 | FEMS Microbiol Letters1997，152，2： | 1 |
| 14 | Syphilis in pregnancy显示文摘 | William J Ledger | 2000 | Sex transm Inf2000，，76： | 1 |
| 15 | Single nucleotide polymorphism its associations with chicken 显示文摘 | Ouyang J H Xie L Nie Q (SNP) at the GHR gene and growth and fat deposition traits (2): 87-95 | 2008 | Brit Pouh Sci2008，49，： | 1 |
| 16 | Prediction and confidence intervals for nonlinear measurement error models without identifiability information显示文摘 | Huwang L Gene H J T | 2002 | Statistics and Probability Letters2002，58，4： | 1 |
| 17 | Polybrominated diphenyl ethers (PBDEs) in sediments and mussel tissues from Hong Kong marine waters 显示文摘 | LIU Y GENE J Z YU HX | 2005 | Marine Pollution Bulletin2005，50，11： | 1 |
| 18 | Molecular phylogeny of Sporothrix schenckii 显示文摘 | Marimon R Gene J Cano J | 2006 | J Clin Mierobiol2006，44，9： | 1 |
| 19 | Agility:competitive weapon of the 1990s and beyond显示文摘 | FLIEDNER GENE VOKURKA ROBERT J | 1997 | Production and Inventory Management1997，8，3： | 1 |
| 20 | Typhimurium显示文摘 | Olsen JE Hoegh-Andersen KH Casades6s J The role of flagella and chemotaxis genes in host pathogen interaction of the host adapted Salmonellaenterica serovar Dublin compared to the broad host range serovar S | 2013 | BMC Microbiol2013，13，1： | 1 |
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