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| 1 | Irritable bowel syndrome and small intestinal bacterial overgrowth:Meaningful association or unnecessary hype显示文摘Irritable bowel syndrome(IBS)is a common condition characterized by abdominal pain or discomfort,bloating,and altered stool form and passage.Small intestinal bacterial overgrowth(SIBO)is a condition in which there is overgrowth of bacteria in small bowel in excess of 105colony forming units per milliliter on culture of the upper gut aspirate.Frequency of SIBO varied from 4%-78%among patients with IBS and from 1%-40%among controls.Higher frequency in some studies might be due to fallacious criteria[postlactulose breath-hydrogen rise 20 PPM above basal within 90 min(early-peak)].Glucose hydrogen breath test(GHBT)has a low sensitivity to diagnose SIBO.Hence,studies based on GHBT might have under-estimated frequency of SIBO.Therefore,it is important to analyze these studies carefully to evaluate whether the reported association between IBS and SIBO is over or under-projected.This review evaluates studies on association between SIBO and IBS,discordance between different studies,their strength and weakness including methodological issues and evidence on therapeutic manipulation of gut flora on symptoms of IBS. | Uday C Ghoshal Deepakshi Srivastava | 2014 | World Journal of Gastroenterology2014，20，10： | 29 |
| 2 | Pathogenesis of achalasia cardia显示文摘Achalasia cardia is one of the common causes of motor dysphagia.Though the disease was first described more than 300 years ago,exact pathogenesis of this condition still remains enigmatic.Pathophysiologically,achalasia cardia is caused by loss of inhibitory ganglion in the myenteric plexus of the esophagus.In the initial stage,degeneration of inhibitory nerves in the esophagus results in unopposed action of excitatory neurotransmitters such as acetylcholine,resulting in high amplitude non-peristaltic contractions(vigorous achalasia);progressive loss of cholinergic neurons over time results in dilation and low amplitude simultaneous contractions in the esophageal body(classic achalasia).Since the initial description,several studies have attempted to explore initiating agents that may cause the disease,such as viral infection,other environmental factors,autoimmunity,and genetic factors.Though Chagas disease,which mimics achalasia,is caused by an infective agent,available evidence suggests that infection may not be an independent cause of primary achalasia.A genetic basis for achalasia is supported by reports showing occurrence of disease in monozygotic twins,siblings and other first-degree relatives and occurrence in association with other genetic diseases such as Down's syndrome and Parkinson's disease.Polymorphisms in genes encoding for nitric oxide synthase,receptors for vasoactive intestinal peptide,interleukin 23 and the ALADIN gene have been reported.However,studies on larger numbers of patients and controls from different ethnic groups are needed before definite conclusions can be obtained.Currently,the disease is believed to be multi-factorial,with autoimmune mechanisms triggered by infection in a genetically predisposed individual leading to degeneration of inhibitory ganglia in the wall of the esophagus. | Uday C Ghoshal Sunil B Daschakraborty Renu Singh | 2012 | World Journal of Gastroenterology2012，18，24： | 20 |
| 3 | Adiponectin: Probe of the molecular paradigm associating diabetes and obesity显示文摘Type 2 diabetes is an emerging health challenge all over the world as a result of urbanization, high prevalence of obesity, sedentary lifestyle and other stress related factors compounded with the genetic prevalence. The health consequences and economic burden of the obesity and related diabetes mellitus epidemic are enormous. Different signaling molecules secreted by adipocytes have been implicated in the development of obesity and associated insulin resistance in type 2 diabetes. Human adiponectin, a 244-amino acid collagen-like protein is solely secreted by adipocytes andacts as a hormone with anti-inflammatory and insulinsensitizing properties. Adiponectin secretion, in contrast to secretion of other adipokines, is paradoxically decreased in obesity which may be attributable to inhibition of adiponectin gene transcription. There are several mechanisms through which adiponectin may decrease the risk of type 2 diabetes, including suppression of hepatic gluconeogenesis, stimulation of fatty acid oxidation in the liver, stimulation of fatty acid oxidation and glucose uptake in skeletal muscle, and stimulation of insulin secretion. To date, no systematic review has been conducted that evaluate the potential importance of adiponectin metabolism in insulin resistance. In this review attempt has been made to explore the relevance of adiponectin metabolism for the development of diabetes mellitus. This article also identifies this novel target for prospective therapeutic research aiming successful management of diabetes mellitus. | Kakali Ghoshal Maitree Bhattacharyya | 2015 | World Journal of Diabetes2015，6，1： | 20 |
| 4 | Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection:A study from northern India显示文摘AIM: To investigate -765G > C COX-2 polymorphism and H pylori infection in patients with gastric adenocarcinoma, peptic ulcer disease (PUD) and non- ulcer dyspepsia (NUD). METHODS: We enrolled 348 adult patients (62 gastric adenocarcinoma, 45 PUD and 241 NUD) undergoing upper gastrointestinal endoscopy at two referral centers between September, 2002 and May, 2007. H pylori infection was diagnosed when any of the four tests (RUT, culture, histopathology and PCR) were positive. Genotyping for -765G > C polymorphism of COX-2 was performed by PCR-RFLP analysis. RESULTS: Frequency of C carrier had significantassociation with gastric adenocarcinoma as compared to NUD [77.4% vs 29%, P < 0.001, odds ratio (OR) 8.20; 95% confidence interval (95% CI), 4.08-16.47] and PUD (77.4% vs 31.1%, P < 0.001; OR 8.04; 95% CI, 3.25-19.90). Risk of gastric adenocarcinoma was significantly higher in patients having C carrier with (OR 7.83; 95% CI 3.09-19.85) and without H pylori infection (OR 7.06; 95% CI, 2.61-19.09). Patients with C carrier and H pylori infection had significant risk for the development of PUD (P < 0.001; OR 5.65; 95% CI, 2.07-15.34). CONCLUSION: -765G > C COX-2 polymorphism with or without H pylori could be a marker for genetic susceptibility to gastric adenocarcinoma. COX-2 polymorphism in presence of H pylori infection might be useful in predicting the risk of PUD. | Ashish Saxena Kashi Nath Prasad Uday Chand Ghoshal Monty Roshan Bhagat Narendra Krishnani Nuzhat Husain | 2008 | World Journal of Gastroenterology2008，14，10： | 18 |
| 5 | Differentiation of Crohn’s disease from intestinal tuberculosis in India in 2010显示文摘Differentiating intestinal tuberculosis from Crohn’s disease (CD) is an important clinical challenge of considerable therapeutic significance. The problem is of greatest magnitude in countries where tuberculosis continues to be highly prevalent, and where the incidence of CD is increasing. The final clinical diagnosis is based on a combination of the clinical history with endoscopic studies, culture and polymerase chain reaction for Mycobacterium tuberculosis, biopsy pathology, radiological investigations and response to therapy. In a subset of patients, surgery is required and intraoperative findings with pathological study of the resected bowel provide a definitive diagnosis. Awareness of the parameters useful in distinguishing these two disorders in each of the different diagnostic modalities is crucial to accurate decision making. Newer techniques, such as capsule endoscopy, small bowel enteroscopy and immunological assays for Mycobacterium tuberculosis, have a role to play in the differentiation of intestinal tuberculosis and CD. This review presents currently available evidence regarding the usefulness and limitations of all these different modalities available for the evaluation of these two disorders. | Anna Benjamin Pulimood Deepak Narayan Amarapurkar Ujjala Ghoshal Mathew Phillip Cannanore Ganesh Pai Duvvur Nageshwar Reddy Birender Nagi Balakrishna Siddhartha Ramakrishna | 2011 | World Journal of Gastroenterology2011，17，4： | 8 |
| 6 | MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer显示文摘 | Fanyin Meng Roger Henson Hania Wehbe–Janek Kalpana Ghoshal Samson T. Jacob Tushar Patel | 2007 | Gastroenterology2007，，2： | 6 |
| 7 | Causal role of Helicobacter pylori infection in gastric cancer: An Asian enigma显示文摘Helicobacter pylori (H pylori ) etiologically 被连接了到胃的 cancer.H pylori 感染在象印度,孟加拉国,巴基斯坦,和泰国一样的少些发达的亚洲国家是更经常的并且比在更多的发达亚洲人国家喜欢日本和中国在早年龄被获得。然而,胃的癌症的频率在与那相比的印度,孟加拉国,巴基斯坦和在日本和中国的泰国是很低的。类似的谜作为与韦斯特相比从非洲被报导了。在印度,孟加拉国,巴基斯坦和泰国的成年人口的 H pylori 感染的 Seroprevalence 从 55% ~ 92% 变化。相反,在中国、日本的成年人的 H pylori 的 seroprevalence 分别地是 44% 和 55% 。在印度,孟加拉国,和泰国的胃的癌症的年度发生率是 10.6, 1.3, 7.1 每 100,000 张人口分别地;相反,那分别地每 100,000 张人口在中国和日本是 32-59 和 80-115。来自印度的几研究没能比控制与胃的癌症在病人显示出 H pylori 感染的高频率。可得到的证据没作为对这个谜的解释在 H pylori 紧张支持差别。尽管有 H pylori 的确定的病因学的角色,因为,状况在亚洲国家是有点神秘的在有感染的高频率的国家,有胃的癌症的更低的率。主人的基因组成和饮食、环境的因素力量解释这个谜。研究着急地被需要解决这个问题。 | Kartar Singh Uday C Ghoshal | 2006 | World Journal of Gastroenterology2006，12，9： | 5 |
| 8 | Impact of Land-Use Change on Soil Microbial Community Composition and Organic Carbon Content in the Dry Tropics显示文摘Restoration of forests poses a major challenge globally, particularly in the tropics, as the forests in these regions are more vulnerable to land-use change. We studied land-use change from natural forest(NF) to degraded forest(DF), and subsequently to either Jatropha curcas plantation(JP) or agroecosystem(AG), in the dry tropics of Uttar Pradesh, India, with respect to its impacts on soil microbial community composition as indicated by phospholipid fatty acid(PLFA) biomarkers and soil organic carbon(SOC) content. The trend of bacterial PLFAs across all land-use types was in the order: NF > JP > DF> AG. In NF, there was dominance of gram-negative bacterial(G^-) PLFAs over the corresponding gram-positive bacterial(G^+) PLFAs. The levels of G^- PLFAs in AG and JP differed significantly from those in DF, whereas those of G^+ PLFAs were relatively similar in these three land-use types. Fungal PLFAs,however, followed a different trend: NF > JP > DF = AG. Total PLFAs, fungal/bacterial(F/B) PLFA ratio, and SOC content followed trends similar to that of bacterial PLFAs. Across all land-use types, there were strong positive relationships between SOC content and G-, bacterial, fungal, and total microbial PLFAs and F/B PLFA ratio. Compared with bacterial PLFAs, fungal PLFAs appeared to be more responsive to land-use change. The F/B PLFA ratio, fungal PLFAs, and bacterial PLFAs explained 91%, 94%,and 73% of the variability in SOC content, respectively. The higher F/B PLFA ratio in JP favored more soil C storage, leading to faster ecosystem recovery compared to either AG or DF. The F/B PLFA ratio could be used as an early indicator of ecosystem recovery in response to disturbance, particularly in relation to land-use change. | Chandra Mohan KUMAR Nandita GHOSHAL | 2017 | Pedosphere2017，27，5： | 5 |
| 9 | Effects of contact lens wearing on keratoconus:a confocal microscopy observation显示文摘AIM: To evaluate the corneal cell morphology of new keratoconus patients wearing two different types of rigid gas-permeable(RGP) contact lenses for 1y.METHODS: Thirty nine eyes of 39 new keratoconus patients were selected and randomly fitted with two types of RGP contact lenses.Group 1 had 21 eyes with regular rigid gas-permeable(RRGP) contact lens and rest 18 eyes were in group 2 with specially designed rigid gas-permeable(SRGP) contact lens.Corneal cell morphology was evaluated using a slit scanning confocal microscope at no-lens wear and after 1y of contact lens wearing.RESULTS: After 1y of contact lens wearing in group 1,the mean anterior and posterior stromal keratocyte density were significantly less(P=0.006 and P=0.001,respectively) compared to no-lens wear.The mean cell area of anterior and posterior stromal keratocyte were also significantly different(P=0.005 and P=0.001) from no-lens wear.The anterior and posterior stromal haze increased by 18.74% and 23.81%,respectively after 1y of contact lens wearing.Whereas in group 2,statistically significant changes were observed only in cell density & area of anterior stroma(P=0.001 and P=0.001,respectively) after 1y.While,level of anterior and posterior stromal haze increased by 16.67% and 11.11% after 1y of contact lens wearing.Polymegathism and pleomorphism also increased after 1y of contact lens wearing in both the contact lens groups.CONCLUSION: Confocal microscopy observation shows the significant alterations in corneal cell morphology of keratoconic corneas wearing contact lenses especially in group 1.The type of contact lens must be carefully selected to minimize changes in corneal cell morphology. | Somnath Ghosh Haliza A Mutalib Sharanjeet Kaur Rituparna Ghoshal Shamala Retnasabapathy | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 4 |
| 10 | 苏哈托后时期印度尼西亚的民主转变和政治发展显示文摘 | 巴拉达斯·戈沙尔(Baladas Ghoshal) 詹向明(译) | 2005 | 南洋资料译丛2005，，4： | 4 |
| 11 | 印度炎症性肠病患者的IL-1受体拮抗剂的基因多态性 | Mittal R.D. Bid H.K. Ghoshal U.C. 郝筱倩 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，12： | 4 |
| 12 | Role of Tumor Necrosis Factor-Alpha (C-863A) Polymorphism in Pathogenesis of Inflammatory Bowel Disease in Northern India显示文摘 | Dinesh Ahirwar Pravin Kesarwani Ranjana Singh Uday Ghoshal Rama Mittal | 2012 | Journal of Gastrointestinal Cancer2012，，2： | 3 |
| 13 | Role of microRNA‐155 at early stages of hepatocarcinogenesis induced by choline‐deficient and amino acid–defined diet in C57BL/6 mice显示文摘 | Bo Wang Sarmila Majumder Gerard Nuovo Huban Kutay Stefano Volinia Tushar Patel Thomas D. Schmittgen Carlo Croce Kalpana Ghoshal Samson T. Jacob | 2009 | Hepatology2009，，4： | 3 |
| 14 | Epidemiological and clinical perspectives on irritable bowel syndrome in India, Bangladesh and Malaysia: A review显示文摘Irritable bowel syndrome(IBS) is a chronic gastrointestinal disorder, common in clinic and in the community. It has a significant impact on both society and patients' quality of life. The epidemiology, clinical presentation, and management of IBS may vary in different geographical regions due to differences in diet, gastrointestinal infection, socio-cultural and psychosocial factors, religious and illness beliefs, symptom perception and reporting. Although previous reviews and consensus reports on IBS in Asia have been published, Asia is quite diverse socio-demographically. In this context, India, Bangladesh and Malaysia share some similarities, including:(1) large proportion of the population living in rural areas;(2) rapid development and associated lifestyle changes in urban areas; and(3) dietary, cultural and religious practices. The present review explores the clinical and epidemiological data on IBS from these three major nations in South and South-East Asia. In-depth review of the literature revealed important differences between IBS in the East, as revealed by studies from these three countries, and the West; these include a predominantly rural profile, differences in bowel habit and symptom profile, raising concern with regards to diagnostic criteria and subtyping of IBS, higher dietary fiber consumption, frequent lactose malabsorption, parasitosis, and possible overlap between post-infectious IBS and tropical sprue. Moreover, the current perception on difference in prevalence of the disorder in these countries, as compared to the West, might be related to variation in survey methods. | M Masudur Rahman Sanjiv Mahadeva Uday C Ghoshal | 2017 | World Journal of Gastroenterology2017，23，37： | 3 |
| 15 | Microbial Biomass Dynamics in a Tropical Agroecosystem: Influence of Herbicide and Soil Amendments显示文摘除草剂的影响独自并且在有有在土壤的动力学上对比资源质量的土壤修正案的联合,微生物引起的生物资源 C (MBC ) , N (MBN ) ,和 P (MBP ) 在热带 dryland agroecosystem 在 rice-wheat-summer 休闲庄稼顺序通过二个年度周期被学习。实验与有 N in the forms of 化肥,小麦稻草, Sesbania aculeata,和农场院子粪肥(FYM ) 的相等的数量的各种各样的土壤修正案独自或在联合包括了除草剂(butachlor ) 的申请。微生物引起的生物资源显示出的土壤在两个庄稼周期的不同时间的变化,减少了从对形成谷物的舞台植物,然后在庄稼成熟舞台增加了到最大值。土壤 MBC 在处理由在减少的独自一个的处理在成长大米的时期期间订的除草剂 + FYM,除草剂 + 小麦稻草,除草剂 + 化肥,和除草剂跟随了的除草剂 + Sesbania aculeata 是最高的。在成长小麦的时期和夏天休闲期间,而除草剂 + FYM,除草剂 + Sesbania,和除草剂 + 化肥治疗显示出类似的层次,土壤 MBC 为除草剂 + 小麦稻草治疗达到了最大值。除了土壤 MBN 在成长大米的时期期间在在除草剂 + 小麦稻草处理上的除草剂 + 化肥处理是更高的之外,土壤 MBN 的全面趋势类似于土壤 MBC 和 MBP 的那些。尽管有通过在有除草剂的联合的外长的土壤修正案的 N 的相等的数量的增加,玷污微生物引起的生物资源回答差别到处理。修正案的资源质量更多在动力学上读了影响玷污微生物引起的生物资源,它可以在干燥热带为 rainfed agroecosystems 的长期的可持续性有含意。 | Alka SINGH Mahesh Kumar SINGH Nandita GHOSHAL | 2016 | Pedosphere2016，26，2： | 3 |
| 16 | MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer显示文摘 | Fanyin Meng Roger Henson Hania Wehbe–Janek Kalpana Ghoshal Samson T. Jacob Tushar Patel | 2007 | Gastroenterology2007，，2： | 2 |
| 17 | Global Strategy: an Organizing Framework 显示文摘 | Ghoshal S | 1987 | Strategic Management Journal1987，8，： | 1 |
| 18 | Social Capital, Intellectual Capital, and the Organizational Advantage 显示文摘 | Janine Nahapiet Sumantra Ghoshal | 1998 | The Academy of Management Review1998，，4： | 1 |
| 19 | Variations in soil microbial biomass and crop roots due to differingresource quality inputs in a tropical dryland agroecosystem显示文摘 | SINGH S GHOSHAL N SINGH K P | 2007 | Soil Biology & Biochemistry2007，39，： | 1 |
| 20 | Social capital, intellectual capital, and the organizational advantage 显示文摘 | Nahapiet J Ghoshal S | 1998 | Academy of Management Review1998，23，2： | 1 |
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