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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | The intemet of things: a survey 显示文摘 | Atzori L Iiera A Giacomo M | 2010 | Computer Networks2010，54，： | 1 |
| 3 | The internet of things:a survey显示文摘 | ATZORI L IERA A GIACOMO M | 2010 | Computer Networks2010，，54： | 1 |
| 4 | The effects of direct electric current on the viability and metabolism of acidophilic bacteria 显示文摘 | JACKMAN S A GIACOMO M SHARMAN A | 1999 | Enzyme Microbial Technology1999，24，1： | 1 |
| 5 | Characterization Of KNOX genes in Medicago truncatula显示文摘 | Di Giacomo E Sestili F Iannelli M A | 2008 | Plant Molecular Biology2008，67，12： | 1 |
| 6 | Underwater autono- mous manipulation for intervention missions AUVs 显示文摘 | GIACOMO M SONG K CHOI J Y | 2009 | O- cean Engineering2009，31，1： | 1 |
| 7 | Comparison of three peripherally-inserted central catheters:pilot study显示文摘 | Di Giacomo M | 2009 | Br J Nurs2009，18，1： | 1 |
| 8 | Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: Clinical and immunological evidence from three patient cases 显示文摘 | Di Giacomo AM Danielli R Guidoboni M | 2009 | Cancer Immunol Immunother2009，58，8： | 1 |
| 9 | Giardia cysts in wastereater treatment plants in Italy显示文摘 | CACCI S M GIACOMO M D AULICINO F A | 2003 | Applied and Environmental Microbiology2003，69，6： | 1 |
| 10 | Information centric networking over SDN and OpenFlow: architectural aspects and ex periments on the OFELIA testbed显示文摘 | Nicola B M Andrea D Giacomo M | 2013 | Computer networks2013，57，32： | 1 |
| 11 | The internet of things a survey显示文摘 | Atzori 1 Iera A Giacomo M | 2010 | Computer networks2010，54，15： | 1 |
| 12 | The Yinand Yang of CD4 ( + ) regulatory T cells in autoimmunityand cancer 显示文摘 | Galgani M Di Giacomo A Matarese G | 2009 | Curr Med Chem2009，16，35： | 1 |
| 13 | Laser induced breakdown spectroscopy applications to meteorites: Chemical analysis and composition profiles显示文摘 | Dell'aglio M Giacomo A D Gaudiuso R | 2010 | Geochimica et Cosmochimica Acta2010，74，24： | 1 |
| 14 | A large interstitial deletion encompassing the amelogenin gene on the short arm of the Y chromosome 显示文摘 | Lattanzi W Giacomo M C Lenato G M | 2005 | Hum Genet2005，116，： | 1 |
| 15 | Gene func tion and expression level influence the insertion/fixation dy namics of distinct transposon families in mammalian introns 显示文摘 | MANUELA S GIORGIA M GIACOMO P C | 2006 | Genome Biol2006，7，12： | 1 |
| 16 | Microbial community structure and dynamics of dark fire-cured tobacco fermentation显示文摘 | GIACOMO M D PAOLINO M SILVESTRO D | 2007 | Applied and Environment Microbiology2007，73，3： | 1 |
| 17 | Derivatized lamellar phosphates and phosphonates of M (Ⅳ) ions 显示文摘 | Dines M B Di M P Giacomo | 1981 | Inorg Chem1981，20，1： | 1 |
| 18 | Identification of early induced genes upon water deficit in potato cell cultures by cDNA - AFLP显示文摘 | Ambrosone A Di Giacomo M Leone A | 2013 | Journal of Plant Research2013，126，1： | 1 |
| 19 | The endonuclease activity of mili fuels piRNA amplification that silences LINE1 el ements显示文摘 | De Fazio S Bartonicek N Di Giacomo M | | 0，，7376： | 1 |
| 20 | Comparison of the UV-degradation chemistry of polypropylene, polyethylene, polyamide 6 and polybutylene teraphthalate显示文摘 | Pieter G Guido M Giacomo V | 1999 | Polym Degra Stab1999，65，3： | 1 |
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