|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Themathematical modeling of hot rolling 显示文摘 | Hodgson P D Mcfarlane D Gibbs R K | 1987 | Journal ofJapan Society for Technology of Plasticity1987，28，： | 1 |
| 3 | Structural interactions between Kisspeptin and GnRH neurons in the me- diobasal hypothalamus of the male rhesus monkey (Maeaca mulatta) as revealed by double immunofluoreseenee and eonfo-al microscopy 显示文摘 | Ramaswamy S Guerriero K A Gibbs R B | 2008 | Endocrinology2008，149，9： | 1 |
| 4 | Interactive software for calculating and displaying X-ray or neutron powder diffractometer patterns of crystalline materials 显示文摘 | Downs R T Bartelmehs K L Gibbs G V | 1993 | American Mineralogist1993，78，910： | 1 |
| 5 | Ultrafine ferrite in low carbon steel显示文摘 | Hodgson P D Hickson M R Gibbs R K | 1999 | Scripta Materialia1999，40，10： | 1 |
| 6 | Texture formation in bulk iron processed by simple shear显示文摘 | Gibbs M A Hartwig K T Cornwell L R | 1998 | Scr Mater1998，39，： | 1 |
| 7 | The effect of chemistry on the formation of ultrafine ferrite in steel显示文摘 | Hickson M R Gibbs R K Hodgson P D | 1999 | ISIJ Int1999，39，11： | 1 |
| 8 | The production of ultrafine ferrite in low-carbon steel by strain-induced transformation显示文摘 | Hickson M R Hurley P J Gibbs R K | 2002 | Metall Mater Trans A2002，33，： | 1 |
| 9 | Ultrafine ferrite in low carbon steel显示文摘 | Hodgson P D Hickson M R Gibbs R K | 1999 | Scripta Materialia1999，40，10： | 1 |
| 10 | Inhibition of endometrial Cancer cell lines by mifepristone (RU486) 显示文摘 | Gibb R K Taglor D D | 1998 | J Soc Gynecol Investy1998，5，6： | 1 |
| 11 | Ruthenium(Ⅲ) chloride-catalyzed chemoselective synthesis of acetals from aldehydes 显示文摘 | De S K Gibbs R A | 2004 | Tetrahedron Lett2004，45，： | 1 |
| 12 | A Mathematical Model to Predict the Mechanical Properties of Hot Rolled C-Mn and Microalloyed Steels显示文摘 | Hodgson P D Gibbs R K | 1992 | ISIJ International1992，32，12： | 1 |
| 13 | The presence of ammonium facilitates nitrite reduction under PHB driven simultaneous nitrification and denitrification显示文摘 | GIBBS B M SHEPHARD L R THIRD K A | 2004 | Water Science and Technology2004，50，10： | 1 |
| 14 | Lion - Human con- flict in the gir forest, India 显示文摘 | Saberwal V K Gibbs J P Chellam R | 1994 | Conservation Biology1994，8，2： | 1 |
| 15 | The production of ultrafine ferrite in low-carbon steel by strain-induced transformation显示文摘 | Hickson M R Hurley P J Gibbs R K | 2002 | Metall Mater Trans A2002，33，4： | 1 |
| 16 | Apoptosis as a Measure of Chemosensitivity to Cisplatin and Taxol Therapy in Ovarian Cancer Cell Lines 显示文摘 | Gibb R K Taylor D D Wan T | 1997 | Gynecol Oncol1997，65，： | 1 |
| 17 | A mathematical model to predict the mechanical properties of hot rolled C-Mn and microalloyed steels 显示文摘 | HODGSON P D GIBBS R K | 1992 | ISIJ International1992，32，12： | 1 |
| 18 | A mathematical model to predict the mechanical properties of hot rolled C-Mn and microalloyed steels 显示文摘 | Hodgson P D Gibbs R K | 1992 | ISU International1992，32，12： | 1 |
| 19 | The production of ultrafine ferrite in low-carbon steel by strain induced transformation显示文摘 | Hickson M R Hurley P J Gibbs R K | 2002 | Metall Mater Trans A2002，33，： | 1 |
| 20 | A mathematical model to predict the mechanical properties of hot rolled C-Mn and microaUoyed steels 显示文摘 | HODGSON P D GIBBS R K | 1992 | ISIJ International1992，32，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员