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| 1 | Aging:A mitochondrial DNA perspective,critical analysis and an update显示文摘The mitochondrial theory of aging, a mainstream theory of aging which once included accumulation of mitochondrial DNA(mt DNA) damage by reactive oxygen species(ROS) as its cornerstone, has been increasingly losing ground and is undergoing extensive revision due to its inability to explain a growing body of emerging data. Concurrently, the notion of the central role for mtDNA in the aging process is being met with increased skepticism. Our progress in understanding the processes of mtDNA maintenance, repair, damage, and degradation in response to damage has largely refuted the view of mt DNA as being particularly susceptible to ROS-mediated mutagenesis due to its lack of 'protective' histones and reduced complement of available DNA repair pathways. Recent research on mitochondrial ROS production has led to the appreciation that mitochondria, even in vitro, produce much less ROS than previously thought, automatically leading to a decreased expectation of physiologically achievable levels of mtDNA damage. New evidence suggests that both experimentally induced oxidative stress and radiation therapy result in very low levels of mtDNA mutagenesis. Recent advances provide evidence against the existence of the 'vicious' cycle of mtDNA damage and ROS production. Meta-studies reveal no longevity benefit of increased antioxidant defenses. Simultaneously, exciting new observations from both comparative biology and experimental systems indicate that increased ROS production and oxidative damage to cellular macromolecules, including mtDNA, can be associated with extended longevity. A novel paradigm suggests that increased ROS production in aging may be the result of adaptive signaling rather than a detrimental byproduct of normal respiration that drives aging. Here, we review issues pertaining to the role of mtDNA in aging. | Inna N Shokolenko Glenn L Wilson Mikhail F Alexeyev | 2014 | World Journal of Experimental Medicine2014，4，4： | 6 |
| 2 | Isolation and proteomic analysis of the SYP61 compartment reveal its role in exocytic trafficking in Arabidopsis显示文摘endomembrane 系统是建筑群和动态细胞内部的 trafficking 网络。它很正在质问在实时追踪单个泡和他们的货物;然而,亲密关系纯化允许泡处于他们的自然状态被孤立以便他们的成分蛋白质能被识别。在植物开创这条途径,我们孤立 SYP61 trans-Golgi 网络分隔空间并且与从另外的细胞器的仅仅最小的干扰执行了它的内容的全面 proteomic 分析。SYP61 的 proteome 揭示了以前没被归功于到这分隔空间的未知功能的蛋白质的协会。我们识别了完全的 SYP61 圈套建筑群,包括规章的蛋白质并且由显示出在 planta 与 SYP61 联系的几这些蛋白质验证了 proteome 数据。我们进一步识别了 SYP121 复杂并且纤维素 synthases,建议那 SYP61 在 exocytic trafficking 和房间墙部件的运输起一个作用到血浆膜。在包括针鼹鼠的 SYP61 proteome 的未知功能的蛋白质的存在提供机会识别新奇 trafficking 部件和货物。处于他们的自然状态的植物泡的亲密关系纯化为复杂 endomembrane 网络的进一步的分析和解剖提供一个基础。途径是广泛地适用的并且能在植物负担得起几张泡人口的学习,它能与 SYP61 泡 proteome 相比。 | Georgia Drakakaki Wilhelmina van de Ven Songqin Pan Yansong Miao Junqi Wang Nana F Keinath Brent Weatherly Liwen Jiang Karin Schumacher Glenn Hicks Natasha Raikhel | 2012 | Cell Research2012，22，2： | 4 |
| 3 | 循环荷载下柔性路面路基变形的动力耦合分析(英文)显示文摘首先简要综述了循环荷载下路基变形的研究现状。然后 ,基于饱和土体的动力耦合分析理论 ,研究了平面应变条件下的柔性路面路基变形的数值分析模型和方法 ,并建立了一个简单的粘弹性动力计算模型来预测路基在循环荷载下的动力反应。该模型可以全面考虑路基材料的剪切模量、阻尼比、孔隙水压力以及永久变形。最后 ,以一个柔性路面为例 ,应用本文方法在循环荷载下的路基变形发展进行了分析。 | 黄雨 Stephen F Brown Glenn R Mcdowell | 2001 | 岩土工程学报2001，23，6： | 3 |
| 4 | RUSLE Revised universal soil loss equation 显示文摘 | KENNETH G R GEORGE R F GLENN A W | 1991 | Journal of soil and water conservation1991，46，： | 1 |
| 5 | The incidence and causes of death following surgery for nonmalignant biliary tract disease显示文摘 | McSherry C K Glenn F | 1980 | Ann Surg1980，131，： | 1 |
| 6 | Encapsulation of plant oils in porous starch microspheres显示文摘 | Glenn G M Klamczynski A P Woods D F | 2010 | Journal of Agricultural and Food Chemistry2010，58，7： | 1 |
| 7 | Glucose metabolism and milk yield of cows infused abomasally or ruminally with starch显示文摘 | KNOWLTON K F DAWSON T E GLENN B P | 1998 | Dairy Sci1998，81，： | 1 |
| 8 | Analysis of LiDAR-derived Topographic Information for Characterizing and Differentiating Landslide Morphology and Activity显示文摘 | Glenn N F Streutker D R Chadwick D J | 2006 | Geonmrphology2006，73，12： | 1 |
| 9 | High-power nanostructured LiMn2-Jvfix04 high-voltage lithium-ion battery electrodematerials: electrochemical impact of electronic conductivity and morphology显示文摘 | MUHARREM K JAFAR F A GLENN G A | 2006 | Chem Mater2006，18，： | 1 |
| 10 | Per- formance ,ruminal fermentation, and site of starch di- gestion in early lactation cows fed corn grain harvested and processed differently 显示文摘 | KNOWLTON K F GLENN B P ERDMAN R A | 1998 | Journal of Dairy Sci- ence1998，81，7： | 1 |
| 11 | Surgieal planning and prosthesis construction using computed tomography, CAD/CAM technology, and the internet for immediate loading of denta| implants 显示文摘 | Stephen F Glenn J Thomas J | 2006 | J Esther Restor Dent2006，18，6： | 1 |
| 12 | Glucose metabolism and milk yield of cows infused abomasally or ruminally with starch 显示文摘 | KNOWLTON K F DAWSON T E GLENN B P | 1998 | Journal of Dairy Science1998，81，12： | 1 |
| 13 | Myxoma of the left atrium:diagnosismade during life with operative and post-mortem find2ings显示文摘 | Goldberg HP Glenn F Dotter CT | 1952 | Circulati on1952，6，1： | 1 |
| 14 | Adventitious root initiation in hypotocol and epicotyls cuttings of estem white pine (Pmns strobes ) seedings显示文摘 | Goldfarb B Welsley P H Glenn R F | 1998 | Physiologia plantamm1998，102，： | 1 |
| 15 | Analysis of LiDAR-derived topographic information for characterizing and differentiating landslide morphology and activity显示文摘 | Glenn N F Streutker D R Chadwick D J | | 0，，01： | 1 |
| 16 | Milk production of dairy cows fed differing concentrations of rumen degraded protein显示文摘 | Kalscheur K F Baldwin R L Glenn B P | 2006 | J Dairy Sci2006，89，： | 1 |
| 17 | A murine model of isolated cardiac steatosis leads to cardiomyopathy显示文摘 | Glenn DJ Wang F Nishimoto M | 2011 | Hypertension2011，57，2： | 1 |
| 18 | Glucose metabolism and milk yield of cows infused abomasally or ruminally with starch显示文摘 | KNOWLTON K F DAWSON T E GLENN B P | 1998 | Dairy Sci1998，81，： | 1 |
| 19 | The use of geostatistics in relating soil moisture to RADARSAT-1 SAR data obtained over the Great Basin,Nevada,USA显示文摘 | Glenn N F Carr G R | 2003 | Computers & Geosciences2003，29，： | 1 |
| 20 | Simulationsof underground structures subjected to dynamic load-ing using the distinct element method显示文摘 | Morris J P Glenn L A Heuze F E | 2002 | Discrete El-ement Methods2002，，8： | 1 |
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