| 7 | The impact of central and obstructive respiratory events on cerebral oxygenation in adults with sleep disordered breathing显示文摘Obstructive sleep apnea(OSA)and central sleep apnea(CSA)are two main types of sleep disordered breathing(SDB).While the changes in cerebral hemodynamics triggered by OSA events have been well studied using near-infrared spectroscopy(NIRS),they are essentially unknown in CSA in adults.Therefore,in this study,we compared the changes in cerebral oxygenation between OSA and CSA events in adult patients using NIRS.Cerebral tissue oxygen saturation(StO_(2))in 13 severe SDB patients who had both CSA and OSA events was measured using frequency-domain NIRS.The changes in cerebral StO_(2)desaturation and blood volume(BV)in the¯rst hour of natural sleep were compared between different types of respiratory events(i.e.,277 sleep hypopneas,161 OSAs and 113 CSAs)with linear mixed-effect models controlling for confounders.All respiratory events occurred during non-rapid eye movement(NREM)sleep.We found that apnea events induced greater cerebral desaturations and BV°uctuations compared to hypopneas,but there was no difference between OSA and CSA.These results suggest that cerebral autoregulation in our patients are still capable to counteract the pathomechanisms of apneas,in particularly the negative intrathoracic pressure(ITP)caused by OSA events.Otherwise larger BV°uctuations in OSA compared to CSA should be observed due to the negative ITP that reduces cardiac stroke volume and leads to lower systematic blood supply.Our study suggests that OSA and CSA may have similar impact on cerebral oxygenation during NREM sleep in adult patients with SDB. | Ramin Khatami Dominik Gnaiger Gordana Hügli Ming Qi Zhongxing Zhang | 2023 | Journal of Innovative Optical Health Sciences2023，16，6： | 1 |
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