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| 1 | Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw显示文摘Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate(BP)-related osteonecrosis of the jaw(ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts(n530); patients with periodontal disease without a history of BP therapy(Control, n510), patients with periodontal disease having history of BP therapy but without ONJ(BP, n55) and patients with BRONJ(BRONJ, n515). Denaturing gradient gel electrophoresis of polymerase chain reaction(PCR)-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ(71.6%), BP(70.3%) and Control(59.1%). Significant differences(P,0.05) in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay(ELISA)results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ. | Smruti Pushalkar Xin Li Zoya Kurago Lalitha V Ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 2 | Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria 显示文摘 | Yoshida M Kobayashi K Kuo T T Bry L Glickman J N Claypool S M Kaser A Nagaishi T Higgins D E Mizoguchi E Wakatsuki Y Roopenian D C Mizoguchi A Lencer W I and Blumberg R S | 2006 | The Journal of Clinical Investigation2006，116，： | 1 |
| 3 | Electromigration induced void drift andcoalescence simulations and a dynamic scaling theory显示文摘 | NATHAN M GLICKMAN E | 2000 | Appl Phys Lett2000，77，21： | 1 |
| 4 | Tei- choic acid hydrolase activity in soil bacteria 显示文摘 | WISE E M WISE J R GLICKMAN R S | 1972 | Pro- ceedings of the National Academy of Sciences of the United States of America1972，69，1： | 1 |
| 5 | Electromigration-induced void drift and coalescence simulations and a dynamic scaling theory 显示文摘 | Nathan M Glickman E | 2000 | Appl Phys Lett2000，77，21： | 1 |
| 6 | Retinal pigment epithelium granules stimulate the photo-oxidation of unsatureated fatty acids显示文摘 | DONTSOV A E GLICKMAN R D OSTROVSKY M A | 1999 | Free Radic Biol Med1999，26，1112： | 1 |
| 7 | Optimal allocation of risk-reduction resources in event trees 显示文摘 | SHERALI H D DESAI E GLICKMAN T S | 2008 | Management Science2008，54，7： | 1 |
| 8 | Selecting optimal alternatives and risk reduction strategies in decision trees 显示文摘 | SHERALI H D DALKIRAN E GLICKMAN T S | 2011 | Operations Research2011，59，3： | 1 |
| 9 | Increased S100beta is associated with reduced cognitive function in healthy older adults显示文摘 | Yadavalli S Gunstad J Glickman E | 2008 | Neuropsychobiology2008，57，3： | 1 |
| 10 | The cost and risk impacts of rerouting railroad shipments of hazardous materials显示文摘 | Theodore S Glickman Erhan E | | 0，，02： | 1 |
| 11 | Brenner tumors of the ovary:sonographic and computed tomographic imaging fea- tures显示文摘 | Green G E Mortele K J Glickman J N | 2006 | J Ultrasound Med2006，25，10： | 1 |
| 12 | Electron-Beam-Induced Domain Poling in LiNbO3 for Two-Dimensional Nonlinear Frequency Conversion 显示文摘 | Glickman Y Winebrand E Arie A | 2006 | Applied Physics Letters2006，88，01： | 1 |
| 13 | Assessment of hazardous material risks for rail yard safety显示文摘 | Glickman T S Erkut E | 2007 | Safety Science2007，45，： | 1 |
| 14 | Blood pressure and survival in the oldest old 显示文摘 | OATES D J BERLOWITZ D R GLICKMAN M E | 2007 | J Am Geriatr Soc2007，55，3： | 1 |
| 15 | Sexual differentiation in three unconventional mammals:spotted hyenas,elephants and tammar wallabies显示文摘 | Glickman S E Short R V Renfree M B | | 0，，04： | 1 |
| 16 | Mechanisms of selective action of pyrethroid insecticides 显示文摘 | Casida J E Gammon D W Glickman A H | 1983 | Annual Review of Pharmacology and Toxicology1983，23，1： | 1 |
| 17 | Temperature and blood pressure following amlodipine overdose显示文摘 | Blankfield RP Iftikhar I Glickman E | 2008 | Wilderness Environ Med2008，19，1： | 1 |
| 18 | Increased S100beta isassociated with reduced cognitive function in healthy older adults显示文摘 | Yadavalli S Gunstad J Glickman E | 2008 | Neuropsychobiology2008，57，3： | 1 |
| 19 | Mechanism of selective action of pyrethroid insecticides显示文摘 | Casida J E Gammon D W Glickman A H | 1983 | Ann Rev Pharmacol Toxicol1983，23，： | 1 |
| 20 | Limitations in the use of SS-CP analysis显示文摘 | Fan E Levin DB Glickman BW | 1993 | Mutat Res1993，288，1： | 1 |
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