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| 1 | Fructose as a key player in the development of fatty liver disease显示文摘We aimed to investigate whether increased consumption of fructose is linked to the increased prevalence of fatty liver.The prevalence of nonalcoholic steatohepatitis(NASH) is 3% and 20% in nonobese and obese subjects,respectively.Obesity is a low-grade chronic inflam-m-atory condition and obesity-related cytokines such as interleukin-6,adiponectin,leptin,and tumor necrosis factor-α may play important roles in the developm-ent of nonalcoholic fatty liver disease(NAFLD).Additionally,the prevalence of NASH associated with both cirrhosis and hepatocellular carcinom-a was reported to be high am-ong patients with type 2 diabetes with or without obesity.Our research group previously showed that consumption of fructose is associated with adverse alterations of plasma lipid profiles and metabolic changes in m-ice,the Am-erican Lifestyle-Induced Obesity Syndrom-e m-odel,which included consum-ption of a high-fructose corn syrup in amounts relevant to that consum-ed by som-e Am-ericans.The observation reinforces the concerns about the role of fructose in the obesity epidem-ic.Increased availability of fructose(e.g.,high-fructose corn syrup) increases not only abnorm-al glucose flux but also fructose m-etabolism-in the hepatocyte.Thus,the anatomic position of the liver places it in a strategic buffering position for absorbed carbohydrates and am-ino acids.Fructose was previously accepted as a beneficial dietary com-ponent because it does not stim-ulate insulin secretion.However,since insulin signaling plays an important role in central m-echanism-s of NAFLD,this property of fructose m-ay be undesirable.Fructose has a selective hepatic m-etabolism,and provokes a hepatic stress response involving activation of c-Jun N-term-inal kinases and subsequent reduced hepatic insulin signaling.As high fat diet alone produces obesity,insulin resistance,and som-e degree of fatty liver with m-inim-al inflam-m-ation and no fibrosis,the fast food diet which includes fructose and fats produces a gene expression signature of increased hepatic fibrosis,inflam-m-ation,endoplasm-ic reticulumstress and lipoapoptosis.Hepatic de novo lipogenesis(fatty acid and triglyceride synthesis) is increased in patients with NAFLD.Stable-isotope studies showed that increased de novo lipogenesis(DNL) in patients with NAFLD contributed to fat accum-ulation in the liver and the developm-ent of NAFLD.Specifically,DNL was responsible for 26% of accum-ulated hepatic triglycerides and 15%-23% of secreted very low-density lipoprotein triglycerides in patients with NAFLD com-pared to an estim-ated less than 5% DNL in healthy subjects and 10% DNL in obese people with hyperinsulinem-ia.In conclusion,understanding the underlying causes of NAFLD form-s the basis for rational preventive and treatm-ent strategies of this m-ajor form-of chronic liver disease. | Metin Basaranoglu Gokcen Basaranoglu Tevfik Sabuncu Hakan Sentürk | 2013 | World Journal of Gastroenterology2013，19，8： | 14 |
| 2 | Novel biomarkers for patients with idiopathic acute anterior uveitis:neutrophil to lymphocyte ratio and platelet to lymphocyte ratio显示文摘AIM: To assess the levels of the neutrophil to lymphocyte ratio(N/L) and the platelet to lymphocyte ratio(P/L) in patients with idiopathic acute anterior uveitis(AAU) and to compare with healthy controls.METHODS: Thirty-six male patients with idiopathic AAU and 36 male healthy subjects were enrolled in this retrospective study.Complete ophthalmological examination and complete blood count measurements results of all subjects were evaluated.RESULTS: There was a significant difference in N/L and P/L between idiopathic AAU and control groups(P=0.006,P=0.022).Also,correlation analysis revealed a significant correlation between C-reactive protein(CRP) and N/L(P= 0.002;r=0.461).CONCLUSION: Our study for the first time provides evidence of N/L and P/L may be useful biomarkers in patients with idiopathic AAU.N/L is correlated with CRP,so it can be a useful biomarker to predict the prognosis in idiopathic AAU. | Cem Ozgonul Erdim Sertoglu Onder Ayyildiz Tarkan Mumcuoglu Murat Kucukevcilioglu Gokcen Gokce Ali Hakan Durukan | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 5 |
| 3 | Comment on survival analysis following early surgical success in intermittent exotropia surgery显示文摘Dear Editor,W e read the article by Lee et al^([1])with great interest.We would like to congratulate the authors for venturing into this area that assess the consecutive recurrence following early success of intermittent exotropia[X(T)]surgery and to determine the clinical factors that affect the survival.However,we would like to make the following comments.In the present study,it was discussed about the correlation of early postoperative overcorrection with long-term outcomes.It is known that most authors would agree to an early postoperative overcorrection in adult patients with X(T)。 | Onder Ayyildz Gokhan Ozge Cem Ozgonul Gokcen Gokce Fatih Mehmet Mutlu | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 2 |
| 4 | Factors affecting recurrence after surgical treatment in cases with ocular surface squamous neoplasia显示文摘AIM: To evaluate the risk factors leading to recurrence in patients with ocular surface squamous neoplasia(OSSN)METHODS: The records of 112 patients with OSSN who underwent treatment and follow-up between February 1999 and August 2018 were reviewed retrospectively.RESULTS: Totally 67 patients(59.8%) were male and 45 patients(40.2%) were female. The mean age at presentation was 63.7 y(range 22-87 y). Partial lamellar scleroconjunctivectomy(PLSC) was performed in 105(93.7%) cases and enucleation was performed in 7(6.3%) cases due to bulbus invasion as the first step treatment. Treatments used in addition to PLSC included cryotherapy in 78 eyes(74.3%), alcohol epitheliectomy in 57 eyes(54.3%) for presence of corneal involvement, and amniotic membrane transplantation in 17 eyes(16.2%) for ocular surface reconstruction. Topical mitomycin C was used in 10 patients(9.5%) and strontium-90(Str-90) treatment in 4(3.8%) patients because surgical margins were tumor positive at the histopathological examination. Postoperative histopathologic diagnoses were squamous cell carcinoma(52 cases), carcinoma in situ(44 cases), moderate conjunctival intraepithelial neoplasia(11 cases), and mild conjunctiva intraepithelial neoplasia(5 cases). At a mean follow-up of 20.1 mo, tumor recurrence was observed in 21(18.8%) cases. The rate of recurrence was found to be lower in cases that underwent supplemental cryotherapy compared to those that did not(P<0.001). There was no metastasis in any case. CONCLUSION: In our series, the recurrence rate is 18.8% and overall globe salvage rate is 90.2% for OSSN at relatively short-term follow-up. | Ibadulla Mirzayev Ahmet Kaan Gunduz Funda Seher Ozalp Ates Gokcen Ozcan Mehmed Ugur Isik | 2019 | International Journal of Ophthalmology(English edition)2019，12，9： | 2 |
| 5 | Piping network design of geothermal district heating systems:Case study of a university campus显示文摘 | YILDIRIM N TOKSOY M GOKCEN G | | 0，，： | 1 |
| 6 | The As(arsenic)System显示文摘 | Gokcen N A | 1989 | Bulletin of Alloy Phase Diagrams1989，10，1： | 1 |
| 7 | Empathic abilities in people with schizophrenia显示文摘 | Bora E Gokcen S Veznedaroglu B | 2008 | Psychiatry Res2008，160，1： | 1 |
| 8 | Thermodynamic assessment of gas removal systems for single-flash geothermal power plants显示文摘 | Ozcan N Y Gokcen G | 2009 | Ap- plied Thermal Engineering2009，29，1415： | 1 |
| 9 | Synthesis of new mannich bases of arylpyridazinones as analgesic and antiinflammatory agents显示文摘 | Mehtap G Gokcen B Mustafa F S | 2005 | Arzneimittelforsch2005，55，6： | 1 |
| 10 | Binary integer formulation for mixedmodel assembly line balancing problem显示文摘 | GOKCEN H EREL E | 1998 | Computers and Industrial Engineering1998，34，2： | 1 |
| 11 | An analytic hierarchy process and two-sided matching based decision support system for military personnel assignment显示文摘 | KORKMAZ I GOKCEN H GETIN~OKUS T | 2008 | Infor- mation Sciences2008，178，14： | 1 |
| 12 | Binary integer formulation for mixed-model assembly line balancing problem显示文摘 | Gokcen H Erel E | 1998 | Computers & Industrial Engineering1998，34，2： | 1 |
| 13 | A shortest route formulation of simpleU-type assembly line balancing problem显示文摘 | Gokcen H Agpak K Gencer C | 2005 | AppliedMathenaticalMode-lling2005，29，4： | 1 |
| 14 | Patterns of osteolysis around total hip components inserted with and with out cement 显示文摘 | Zicat B Engh CA Gokcen E | 1995 | J Bone Joint Surg1995，77，： | 1 |
| 15 | The Mn-N (Manganese-Nitrogen) system显示文摘 | N. A. Gokcen | 1990 | Bulletin of Alloy Phase Diagrams1990，，1： | 1 |
| 16 | Evaluation of the Potential for Districts/Counties to Become Provinces with Respect to the Level of Urbanization in Turkey显示文摘 | Gokcen Kilinc NuranZeren Gulersoy | 2011 | European Planning Studies2011，，8： | 1 |
| 17 | 显示文摘 | Celik E Gokcen Z Ak Azem N F | 2006 | Mate Sci Eng B2006，132，3： | 1 |
| 18 | An analytic hierarchy process and two-sided matching based decision support system for military personnel assignment显示文摘 | Korkmaz I Gokcen H Cetinyokus T | 2008 | Information Sciences2008，178，14： | 1 |
| 19 | A Goal Programming Approach to Mixed-Model Assembly Line Balancing Problem显示文摘 | Gokcen H Erel E | 1997 | International Journal of Production Economics1997，，2： | 1 |
| 20 | Shortest-route formulation of mixed-model assembly line balancing problem显示文摘 | EREL E GOKCEN H | 1999 | European Journal of Operational Research1999，116，1： | 1 |
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