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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Resolution of persistent periapical infection by endodontic surgery显示文摘 | Ferreira F B Ferreira A L Gomes B P | 2004 | Int Endod J2004，37，1： | 1 |
| 3 | Combining me- ta-learning and search techniques to select parameters for support vector machines 显示文摘 | Taciana A F Gomes Ricardo B C Prudeneio | 2012 | Neuroeomputing2012，75，1： | 1 |
| 4 | Communication from the Commission:A Sustainable Europe for a Better World:A European Union Strategy for Sustainable Development显示文摘 | GOMES F B MORAES J C DE | 2014 | Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine2014，228，4： | 1 |
| 5 | Comparative study of geometry and bonding character for methoxy radical adsorption on noble metals显示文摘 | GOMES J R B GOMES J A N F | 2000 | J Mol Struct-Theochem2000，503，3： | 1 |
| 6 | Array comparative genornic hybridization in prenatal diagnosis :another experience显示文摘 | Vialard F Molina Gomes D Leroy B | 2009 | Fetal Diagn Ther2009，25，： | 1 |
| 7 | Modeling of superheated fuel spray and vaporization显示文摘 | Zuo B F Gomes A M Rutland C J | 2000 | International Journal of Engine Research2000，1，4： | 1 |
| 8 | A DFT study of the methanol oxidation catalyzed by a copper surface显示文摘 | GOMES J R B GOMES J A N F | 2001 | Surf Sci2001，471，13： | 1 |
| 9 | In vitro antimicrobial activity and arnica Montana against oral pathogens显示文摘 | Koo H Gomes B P F A Rosalen P L | 2000 | Arch Oral Biol2000，45，： | 1 |
| 10 | Three-year outcome after coronary stenting versus bypass surgery for the treatment of multivessel disease显示文摘 | Legrand VM Serruys PW Unger F van Hout BA Vrolix MC Fransen GM Nielsen TT Paulsen PK Gomes RS de Queiroz e Melo JM Neves JP Lindeboom W Backx B Arterial Revascularization Therapy Study (ARTS) Investigators | 2004 | Circulation2004，109，9： | 1 |
| 11 | Array comparative genomic hybridization in prenatal diagnosis another experience显示文摘 | Vialard F Molina Gomes D Leroy B | 2009 | Fetal Diagn Ther2009，25，2： | 1 |
| 12 | Induction melting of y- TiM in CaO crucibles 显示文摘 | Gomes F Joaquim B Silva R C | 2008 | Intermetallics2008，16，11： | 1 |
| 13 | Effectiveness of 2% chlorhexidine gel and calcium hydroxide against Enterococcus faecalis in bovine root dentine in vitro显示文摘 | Gomes B P Souza S F Ferraz C C | 2003 | Int Endod J2003，36，4： | 1 |
| 14 | Minerals and clay minerals in medical geology显示文摘 | Gomes C S F Silva J B P | 2007 | Applied Clay Science2007，36，13： | 1 |
| 15 | Microbio- logical examination of infected dental root canals显示文摘 | GOME B P F A PINHEIRO E T GADE-NETO C R | 2004 | Oral Microb Im- munol2004，19，2： | 1 |
| 16 | Chemical characterization of aromatic compounds inextra heavy gas oil by comprehensive two-dimensionalgas chromatography coupled to time*of-flight massspectrometry显示文摘 | AVILA B M F PEREIRA R GOMES A 0 | 2011 | Journal of Chromatography A2011，1218，： | 1 |
| 17 | Natural and ge- netically engineered proteins for tissue engineering 显示文摘 | GOMES S LEONOR I B MANOJ F | 2012 | Prog Polym Sci2012，37，1： | 1 |
| 18 | Array comparativegenomic hybridization in prenatal diagnosis another experience显示文摘 | Vialard F Molina Gomes D Leroy B | 2009 | Fetal Diagn Ther2009，25，2： | 1 |
| 19 | Array comparative genomic hybridization in prenatal diagnosis:another experience显示文摘 | Vialard F Molina Gomes D Leroy B | 2009 | Fetal Diagn Ther2009，25，2： | 1 |
| 20 | In vitro assessm ent of the imm ed iate and pro longed ant in icrobial action of ch lorhexidine gel as an endodont ic irrigant against Enterococcus faecal is显示文摘 | Dametto F R Ferraz C C Gomes B P | 2005 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2005，99，6： | 1 |
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