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您的检索式：作者名="GONG Tongdan"
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| 1 | Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival显示文摘Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression. | Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，2： | 2 |
| 2 | Heat Transfer Model Founded and Regional Suitability Analysis of Photovoltaic Walls with Different Structures显示文摘The heat transfer performance and suitability of photovoltaic walls with different structures in different regions have been studied. First, a quasi-two-dimensional calculation model was established to realize the simulation of photovoltaic walls with three structural forms(ordinary wall with air layer opening, air layer closed and no air layer);combined with the experimental data, the accuracy of the two-dimensional calculation model was verified. Based on the simulation results, the suitability of different structural forms of photovoltaic walls in areas with different climatic conditions were compared and analyzed. The results of the study show that the southern China that emphasize the purpose of ventilation and heat dissipation should adopt photovoltaic walls with open air layers, and the northern regions that emphasize the purpose of heat preservation and heat insulation should adopt photovoltaic walls with closed air layers;for transitional areas, the type of photovoltaic wall should be considered comprehensively according to environmental conditions and local building conditions. | ZHANG Wenjie ZHAO Yingbo LIU Wei GONG Tongdan LIU Kangyong | 2022 | Journal of Thermal Science2022，31，6： | 0 |
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