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161篇 您的检索式:作者名="GRANGE L"
    题名 作者 年代 出处 被引量
1Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?显示文摘Our understanding of the microbial involvement in inflammatory bowel disease(IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or 'dysbiosis' is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity(including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years.Georgina L Hold Megan Smith Charlie Grange Euan Robert Watt Emad M El-Omar Indrani Mukhopadhya 2014World Journal of Gastroenterology2014,20,5:21
2Differences in MMPs and TIMP-1 expression between intervertebral disc and disc herniation 显示文摘Baillet A Grange L Trocme C 2013Joint Bone Spine2013,80,3:1
3The adsorption of nitric oxide on supported Co-Mo hydrodesulfurization catalysts: A review显示文摘PORTELA L GRANGE P DELMON B 1995Catal Rev: Sci Eng1995,37,4:1
4A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximah显示文摘Marotte H Pallot-Prades B Grange L 2007Arthritis Res Ther2007,9,3:1
5Selective catalytic reduction of NO by ammonia on V2O5-SO4^2-/TiO2 catalysts prepared by the sol-gel method显示文摘Baraket L Ghorbel A Grange P 2007Applied catalysis B: Environmental2007,72,12:1
6Splicing factor and exon profiling across human tissues显示文摘DE LA GRANGE P GRATADOU L DELORD M 2010Nucleic Acids Res2010,38,9:1
7A topological route choice model for metro显示文摘RAVEAU S MUNOZ J C GRANGE L D 2011Transportation Research Part A2011,45,2:1
8Application of the Doppler ultrasound blood flow detector in supraclavicular brachial plexus block 显示文摘La Grange P Foster P Pretorius L 1978Br J Anaesth1978,50,9:1
9Coexpreasion of the Bacillus pumilus β-xylosidase (xynB) gene with the Trichoderma reesei β-xylanase 2 (xyn2) gene in the yeast Saccharomyces cerevisiae显示文摘Grange D C L Claeyssem M Pretorius I S 2000Appl Microbiol Biotechnol2000,54,:1
10Early EUS of the bile duct before endoscopic sphincterotomy for acute biliary pancreatitis显示文摘Frédéric Prat Jo?l Edery Bruno Meduri Renaud Chiche Charles Ayoun Michel Bodart Didier Grange Fran?oise Loison Pierre Nedelec Mohamed Sa?d Sbai-Idrissi Alain Valverde Bertrand Vergeau 2001Gastrointestinal Endoscopy2001,,6:1
11Selective catalytic reduction of NO by NH3 on sulfated titanium-pillared clay显示文摘Khalfallah B L Ghorbel A Grange P 2003Catalysis Letters2003,86,4:1
12Selective catalytic reduction of NO by NH3 on sulfated titaniumpillared clay显示文摘BOUDALI L K GHORBEL A GRANGE P 2003Catalysis Letters2003,86,4:1
13Sonography versus electrodiagnosis for the diagnosis of carpal tunnel syndrome in routine practice显示文摘Boutte C Gaudin P Grange L 2009Rev Neurol (Paris)2009,165,5:1
14Application of the Doppler ultrasound bloodflow detector in supraclavicular brachial plexus block显示文摘La Grange P Foster P A Pretorius L K 1978Br J Anaesth1978,50,9:1
15Enantioselectiveα-benzylation of aldehydes via photoredox organocatalysis显示文摘Shih H W Vander Wal M N Grange R L 2010J Am Chem Soc2010,132,13:1
16SCR of NO by NH3 over V2O5 supported sulfated Ti-pillared clay: Reactivity and reducibility of catalysts显示文摘KHALFALLAH BOUDALI L GHORBEL A GRANGE P 2006Appl Catal A : General2006,305,1:1
17Preparation and characterization of sulfated titanium-modified pillared montmorillonite显示文摘Del Castillo H L Gil A Grange P 1997Catalysis Letters1997,43,:1
18Application of the Doppler ultrasound blood flow detector in supraclavicular brachial plexus block显示文摘La Grange P Foster P Pretorius L 1978Br J Anaesth1978,50,9:1
19Epidemiological risk factors associated with high global frequency of inapparent dengue virus infections 显示文摘Grange L Simon-Loriere E Sakuntabhai A 2014Front Immuno]2014,5,:1
20Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes 显示文摘ROUSSET F NGUYEN M V GRANGE L 2013PLoS One2013,8,66:1
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