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| 1 | Efficacy of infliximab in acute severe ulcerative colitis:A single-centre experience显示文摘AIM:To suggest infliximab(IFX) is effective for acute severe ulcerative colitis,from real-life clinical practice.METHODS:All patients receiving IFX for the treatment of acute severe ulcerative colitis in a single centre were included.Data were extracted from clinical records in order to assess response to IFX therapy.The primary endpoint was colectomy-free survival,and secondary outcomes included glucocorticosteroid-free remission and safety,which was evaluated by recording deaths and adverse events.Demographic and clinical characteristics of those who underwent colectomy and those who were colectomy-free,both at discharge from their index admission,and during follow-up after an initial response to IFX were compared.RESULTS:Forty-four patients(16 females,mean age 36 years) received IFX between May 2006 and January 2012 for acute severe ulcerative colitis.The median duration of follow-up post-first infusion was 396 d(interquartile range = 173-828 d).There were 21(47.7%) patients with < 1 year of follow-up,10(22.7%) with 1 years to 2 years of follow-up,and 13(29.5%) with > 2 years of follow-up post-first infusion of IFX.Overall,35(79.5%) responded to IFX,avoiding colectomy during their index admission,29(65.9%) were colectomyfree at last point of follow-up(median follow-up 396 d),and 25(56.8%) were in glucocorticosteroid-free remission at end of follow-up.There was one death from post-operative sepsis,20 d after a single IFX infusion.Colectomy rates were generally lower among those 'bridging' to thiopurine.Of 18 patients 'bridged' to thiopurine therapy,17(94.4%) were colectomyfree,and 15(83.3%) were in glucocorticosteroid-free remission at study end.No predictors of response were identified.CONCLUSION:IFX is effective for acute severe ulcerative colitis in real-life clinical practice.Two-thirds of patients avoided colectomy,and more than 50% were in glucocorticosteroid-free remission. | Stephen J Halpin P John Hamlin Daniel P Gree Lisa Warren Alexander C Ford | 2013 | World Journal of Gastroenterology2013，19，7： | 1 |
| 2 | Mass transfer in rolling rotary kilns : a novel approach 显示文摘 | HEYDENRYCH M D GREE P HEESINK A B M | 2002 | Chemical Engineering Science2002，57，： | 1 |
| 3 | The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death显示文摘 | Manero F Gautier F Gallenne T Cauquil N Gree D Cartron P F | 2006 | Cancer Res2006，66，： | 1 |
| 4 | Trimethylsulfonium methylsulfate, a simple and efficient epoxidizing agent 显示文摘 | Mosset P Gree R | 1985 | Synthetic Communications1985，15，8： | 1 |
| 5 | Immunization against viral respiratory disease:a review显示文摘 | H B GREE NBERG P A PIEDRA | | 0，，11： | 1 |
| 6 | Human papillomavirus testing for primary cervical cancer screening 显示文摘 | Gree M Davies P | 2008 | Expert Rev Mol Diagn2008，8，5： | 1 |
| 7 | Trimethylsulfonium methylsulfate, a simple and efficient epoxidizing agent 显示文摘 | Mosset P Gree R | 1985 | J Org Chem1985，15，8： | 1 |
| 8 | Aging and structure/ activity characteristics of Cr ZSM5 catalysts during exposure to chlorinated VOCs显示文摘 | Rachapudi R Chintawar P S Gree H L | 1999 | Journal of catalysis1999，185，： | 1 |
| 9 | Mass transfer in roiling rotary kilns:a novel approach 显示文摘 | Heydenrych M D Gree P Heesink A B | 2002 | Chemical Engineering Science2002，57，： | 1 |
| 10 | Trimethylsulfonium methyl sulfate,a simple and efficient epoxidizing agent显示文摘 | Mosset P Gree R | | 0，，08： | 1 |
| 11 | Pre-industrial and contemporary fluxes of nitrogen through rivers: a global assessment based on typology显示文摘 | Gree P A Vlxtirtismarty C J Meybeck M | 2004 | Biogeochemistry2004，68，1： | 1 |
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