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| 1 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 2 | Use of genotype-environment interactions to elucidate the pattern of maize root plasticity to nitrogen deficiency显示文摘Maize(Zea mays L.) root morphology exhibits a high degree of phenotypic plasticity to nitrogen(N) de ficiency,but the underlying genetic architecture remains to be investigated Using an advanced BC_4F_3 population,we investigated the root growth plasticity under two contrasted N levels and identi fied the quantitative trait loci(QTLs) with QTL-environment(Q×E)interaction effects. Principal components analysis(PCA) on changes of root traits to N de ficiency(D LN-HN) showed that root length and biomass contributed for 45.8% in the same magnitude and direction on the first PC,while root traits scattered highly on PC_2 and PC_3. Hierarchical cluster analysis on traits for D LN-HN further assigned the BC_4F_3 lines into six groups,in which the special phenotypic responses to N de ficiency was presented These results revealed the complicated root plasticity of maize in response to N de ficiency that can be caused by genotype environment(G×E) interactions. Furthermore,QTL mapping using a multi-environment analysis identi fied 35 QTLs for root traits. Nine of these QTLs exhibited signi ficant Q×E interaction effects. Taken together,our findings contribute to understanding the phenotypic and genotypic pattern of root plasticity to N de ficiency,which will be useful for developing maize tolerance cultivars to N de ficiency. | Pengcheng Li Zhongjuan Zhuang Hongguang Cai Shuai Cheng Ayaz Ali Soomro Zhigang Liu Riliang Gu Guohua Mi Lixing Yuan Fanjun Chen | 2016 | Journal of Integrative Plant Biology2016，58，3： | 8 |
| 3 | From Green Super Rice to green agriculture:Reaping the promise of functional genomics research显示文摘Producing sufficient food with finite resources to feed the growing global population while having a smaller impact on the environment has always been a great challenge.Here,we review the concept and practices of Green Super Rice(GSR)that have led to a paradigm shift in goals for crop genetic improvement and models of food production for promoting sustainable agriculture.The momentous achievements and global deliveries of GSR have been fueled by the integration of abundant genetic resources,functional gene discoveries,and innovative breeding techniques with precise gene and whole-genome selection and efficient agronomic management to promote resource-saving,environmentally friendly crop production systems.We also provide perspectives on new horizons in genomic breeding technologies geared toward delivering green and nutritious crop varieties to further enhance the development of green agricul-ture and better nourish the world population. | Sibin Yu Jauhar Ali Shaochuan Zhou Guangjun Ren Huaan Xie Jianlong Xu Xinqiao Yu Fasong Zhou Shaobing Peng Liangyong Ma Dingyang Yuan Zefu Li Dazhou Chen Ruifeng Zheng Zhigang Zhao Chengcai Chu Aiqing You Yu Wei Susong Zhu Qiongyao Gu Guangcun He Shigui Li Guifu Liu Changhua Liu Chaopu Zhang Jinghua Xiao Lijun Luo Zhikang Li Qifa Zhang | 2022 | Molecular Plant2022，15，1： | 6 |
| 4 | PEA3 activates CXCR4 transcription in MDA-MB-231 and MCF7 breast cancer cells显示文摘(CXCR4 ) CXC chemokine 受体 4 是被显示了调停的房间表面受体包括肺,胸,肾,和前列腺的许多稳固的肿瘤的转移肿瘤。在这研究,我们发现 et 变体基因 4 的 overexpression (PEA3 ) 能在人的 MDA-MB-231 和 MCF-7 乳癌房间提高 CXCR4 mRNA 水平和 CXCR4 倡导者活动。PEA3 支持了 CXCR4 表示和乳癌转移。染色质 immunoprecipitation 试金证明 PEA3 能与 PEA3 表示向量在房间 transfected 绑在 CXCR4 倡导者。PEA3 siRNA 在 MDA-MB-231 和 MCF-7 房间稀释了 CXCR4 倡导者活动和 PEA3 的绑定到 CXCR4 倡导者。这些结果显示 PEA3 能激活 CXCR4 倡导者抄写并且支持乳癌转移。 | Shengmei Gu Li Chen Qi Hong Tingting Yan Zhigang Zhuang Qiaoqiao Wang Wei Jin Hua Zhu Jiong Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 4 |
| 5 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study显示文摘 | Qiujin Shen Jia Fan Xin-Rong Yang Yexiong Tan Weifeng Zhao Yang Xu Ning Wang Yongdong Niu Zheng Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Bin Yu Ning Tang Wei Chu Min Wang Jinhua Wu Zhigang Zhang Shengli Yang Jianren Gu Hongyang Wang Wenxin Qin | 2012 | Lancet Oncology2012，，8： | 4 |
| 6 | Adsorption of phenol from aqueous solution by a hierarchical micro-nano porous carbon material显示文摘A hierarchical micro-nano porous carbon material (MNC) was prepared using expanded graphite (EG), sucrose, and phosphoric acid as raw materials, followed by sucrose-phosphoric acid solution impregnation, solidification, carbonization and activation. Nitrogen adsorption and mercury porosimetry show that mixed nanopores and micropores coexist in MNC with a high specific surface area of 1978 m2·g-1 and a total pore volume of 0.99 cm3·g-1. In addition, the MNC is found to consist of EG and activated carbon with the latter deposited on the interior and the exterior surfaces of the EG pores. The thickness of the activated carbon layer is calculated to be about one hundred nanometers and is further confirmed by scanning electron microscope (SEM) and transmission election microscope (TEM). A maximum static phenol adsorption of 241.2 mg·g-1 was obtained by using MNC, slightly higher than that of 220.4 mg·g-1 by using commercial activated carbon (CAC). The phenol adsorption kinetics were investigated and the data fitted well to a pseudo-second-order model. Also, an intra-particle diffusion mechanism was proposed. Furthermore, it is found that the dynamic adsorption capacity of MNC is nearly three times that of CAC. The results suggest that the MNC is a more efficient adsorbent than CAC for the removal of phenol from aqueous solution. | Liu Chengbao Chen Zhigang Ni Chaoying Chen Feng Gu Cheng Cao Yu Wu Zhengying Li Ping | 2012 | Rare Metals2012，31，6： | 4 |
| 7 | Application of Optical Tweezers in the Research of Molecular Interaction between Lymphocyte Function Associated Antigen-1 and Its Monoclonal Antibody显示文摘Lymphocyte function associated antigen-1 (CD11a/CD18, LFA-1) plays an important role in the structure of the immunological synapse and is required for efficient lysis of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. To study the activation mode of LFA-1 on the NK cell surface, optical tweezers were used in the work. As an emerging technology, optical tweezers are widely used to manipulate microscopic objects and measure the forces of molecular interactions in the field of biological research. In our study, a new platform was constructed to study the single molecular behavior of receptor on cell surface using optical tweezers. Based on the platform, the interaction between an NK cell and a polystyrene microsphere coated with anti-LFA-1 antibody was observed. The result confirmed that the adhesion forces between an NK cell and a polystyrene bead were time-dependent. According to our findings, we propose that anti-LFA-1 antibody may cause the clustering of LFA-1 on NK cell surface. | Haodong Chen Kuikui Ge Yinmei Li Jianguang Wu Yongqiang Gu Haiming Wei Zhigang Tian | 2007 | Cellular & Molecular Immunology2007，4，3： | 3 |
| 8 | Optimization of Processing Parameters of Power Spinning for Bushing Based on Neural Network and Genetic Algorithms显示文摘A neural network model of key process parameters and forming quality is developed based on training samples which are obtained from the orthogonal experiment and the finite element numerical simulation. Optimization of the process parameters is conducted using the genetic algorithm (GA). The experimental results have shown that a surface model of the neural network can describe the nonlinear implicit relationship between the parameters of the power spinning process:the wall margin and amount of expansion. It has been found that the process of determining spinning technological parameters can be accelerated using the optimization method developed based on the BP neural network and the genetic algorithm used for the process parameters of power spinning formation. It is undoubtedly beneficial towards engineering applications. | Junsheng Zhao Yuantong Gu Zhigang Feng | 2019 | Journal of Beijing Institute of Technology2019，28，3： | 3 |
| 9 | Enhancing phosphorus uptake efficiency through QTL-based selection for root system architecture in maize显示文摘Root system architecture(RSA) plays an important role in phosphorus(P) acquisition,but enhancing P use efficiency(PUE) in maize via genetic manipulation of RSA has not yet been reported.Here,using a maize recombinant inbred line(RIL) population,we investigated the genetic relationships between PUE and RSA,and developed P-efficient lines by selection of quantitative trait loci(QTLs) that coincide for both traits.In low-P(LP) fields,P uptake efficiency(Pup E) was more closely correlated with PUE(r =0.48-0.54),and RSA in hydroponics was significantly related to Pup E(r=0.25-0.30) but not to P utilization efficiency(Put E).QTL analysis detected a chromosome region where two QTLs for PUE,three for Pup E and three for RSA were assigned into two QTL clusters,Cl-bin3.04 a and Cl-bin3.04 b.These QTLs had favorable effects from alleles derived from the large-rooted and high-Pup E parent.Marker-assisted selection(MAS) identified nine advanced backcross-derived lines carrying Cl-bin3.04 a or Cl-bin3.04 b that displayed mean increases of 22%e26% in PUE in LP fields.Furthermore,a line L224 pyramiding Clbin3.04 a and Cl-bin3.04 b showed enhanced Pup E,relying mainly on changes in root morphology,rather than root physiology,under both hydroponic and field conditions.These results highlight the physiological and genetic contributions of RSA to maize Pup E,and provide a successful study case of developing P-efficient crops through QTL-based selection. | Riliang Gu Fanjun Chen Lizhi Long Hongguang Cai Zhigang Liu Jiabo Yang Lifeng Wang Huiyong Li Junhui Li Wenxin Liu Guohua Mi Fusuo Zhang Lixing Yuan | 2016 | Journal of Genetics and Genomics2016，43，11： | 3 |
| 10 | A similar particle optimi-zation algorithm for permutation flowshop scheduling to mini-mize makespan显示文摘 | Lian Zhigang Gu Xingsheng Jiao Bin | 2006 | Applied Mathematics and Computation2006，175，1： | 1 |
| 11 | A novel particle optimiza-tion algorithm for permutation flowshop scheduling to minimize makespan显示文摘 | Lian Zhigang Gu Xingsheng Jiao Bin | 2008 | Chaos Solutions&Fractals2008，35，5： | 1 |
| 12 | A Novel particle swarm optimization algorithm for permutation flow shop scheduling to minimize makespan显示文摘 | Lian Zhigang Gu Xingsheng Jiao Bin | 2008 | Chaos Solitons and Fractals2008，35，5： | 1 |
| 13 | A similar panicle swarm optimization algorithm for permutation flowshop scheduling to minimize makespan显示文摘 | Lian Zhigang Gu Xingsheng Jiao Bin | 2006 | Applied Mathematics and Computation2006，175，1： | 1 |
| 14 | A dynamic inertia weight particle swarm optimization algorithm显示文摘 | Bin Jiao Zhigang Lian Xingsheng Gu | 2006 | Chaos, Solitons and Fractals2006，，3： | 1 |
| 15 | Optimization of natural fermentative medium for selenium-enriched yeast by D-optimal mixture design显示文摘 | YIN Hongfei CHEN Zhigang GU Zhenxin | 2009 | LWT-Food Science and Technology2009，42，1： | 1 |
| 16 | A novel particle swarm optimization algorithm for permutation flow-shop scheduling to minimize makespan 显示文摘 | LIAN Zhigang GU Xingsheng JIAO Bin | 2008 | Chaos Solitons and Fractals2008，35，： | 1 |
| 17 | Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells显示文摘 | Jinhai Gu Gang Li Tao Sun Yuhang Su Xulong Zhang Jie Shen Zhigang Tian Jian Zhang | 2008 | Journal of Neuro - Oncology2008，，1： | 1 |
| 18 | Tunable chiroptical application by encapsulating achiral lanthanide complexes into chiral MOF thin films显示文摘Chiral metal-organic frameworks(chirMOFs)have been widely considered on enantioselective adsorption/separation,asymmetric catalysis,biological and nonlinear optical applications.However,chirMOFs are facing a great challenge in development of chiroptical thin films with circularly polarized luminescence(CPL)property.Here,we first report CPL thin films by encapsulating achiral lanthanide complexes Ln(acac)_(3)(Ln=Eu_(a)Tb_(b)Gd_(c))into the pores of surface-coordinated chirMOF thin films(SURchirMOF)[Zn_(2)(cam)_(2)dabco]_(n) with layer by layer(Ibl)encapsulation strategy.Due to the unique combination of chiral porous MOF and adjustable luminescent complexes in the host-guest thin films,the obtained Ln(acac)_(3)@SURchirMOF possess strong and tunable CPL property with high dissymmetry factors.The compared CPL and fluorescent lifetime results show that the advantage of this preparation strategy can effectively achieve energy transfer from Ln(acac)_(3) to SURchirMOF,resulting in an excellent CPL performance.This study not only provides a novel strategy to develop new types of chiral thin films but also offers an efficient approach for tunable chiroptical applications. | Rui Zhai Yihong Xiao Zhigang Gu Jian Zhang | 2022 | Nano Research2022，15，2： | 1 |
| 19 | A Similar Particle Swarm Optimization Algorithm for Permutation Flowshop Scheduling to Minimize Makespan显示文摘 | Lian Zhigang Gu Xingsheng Jiao Bin | 2006 | Applied Mathematics and Computation2006，175，1： | 1 |
| 20 | Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin显示文摘 | Jin Song Zhouhong Ge Xinrong Yang Qin Luo Cun Wang Haiyan You Tianxiang Ge Yun Deng Hechun Lin Yongqi Cui Wei Chu Ming Yao Zhigang Zhang Jianren Gu Jia Fan Wenxin Qin | 2014 | Cancer Letters2014，，： | 1 |
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