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| 1 | Cancer stem cell impact on clinical oncology显示文摘Cancer is a widespread worldwide chronic disease. In most cases, the high mortality rate from cancer correlates with a lack of clear symptoms, which results in late diagnosis for patients, and consequently, advanced tumor disease with poor probabilities for cure, since many patients will show chemo-and radio-resistance. Several mechanisms have been studied to explain chemo-and radio-resistance to anti-tumor therapies, including cell signaling pathways, anti-apoptotic mechanisms, stemness, metabolism, and cellular phenotypes. Interestingly, the presence of cancer stem cells(CSCs), which are a subset of cells within the tumors, has been related to therapy resistance. In this review, we focus on evaluating the presence of CSCs in different tumors such as breast cancer, gastric cancer, lung cancer, and hematological neoplasias, highlighting studies where CSCs were identified in patient samples. It is evident that there has been a great drive to identify the cell surface phenotypes of CSCs so that they can be used as a tool for anti-tumor therapy treatment design. We also review the potential effect of nanoparticles, drugs, natural compounds, aldehyde dehydrogenase inhibitors, cell signaling inhibitors, and antibodies to treat CSCs from specific tumors. Taken together, we present an overview of the role of CSCs in tumorigenesis and how research is advancing to target these highly tumorigenic cells to improve oncology patient outcomes. | Mariel E Toledo-Guzmán Gabriele D Bigoni-Ordonez Miguel Ibanez Hernandez Elizabeth Ortiz-Sánchez | 2018 | World Journal of Stem Cells2018，10，12： | 4 |
| 2 | 磺酸多相催化剂用于二甲基亚砜中C_6-单糖脱水制5-羟甲基糠醛(英)显示文摘Sulfonic acid-functionalized heterogeneous catalysts have been evaluated in the catalytic dehydration of C(,monosaccharides into 5-hydroxymethylfurfural(HMF) using dimethyl sulfoxide(DMSO)as solvent.Sulfonic commercial resin Amberlyst-70 was the most active catalyst,which was ascribed to its higher concentration of sulfonic acid sites as compared with the other catalysts,and it gave 93 mol%yield of HMF from fructose in 1 h.With glucose as the starting material,which is a much more difficult reaction,the reaction conditions(time,temperature,and catalyst loading) were optimized for Amberlyst-70 by a response surface methodology,which gave a maximum HMF yield of 33 mol%at 147 °C with 23 wt%catalyst loading based on glucose and 24 h reaction time.DMSO promotes the dehydration of glucose into anhydroglucose,which acts as a reservoir of the substrate to facilitate the production of HMF by reducing side reactions.Catalyst reuse without a regeneration treatment showed a gradual but not very significant decay in catalytic activity. | Gabriel Morales Juan A.Melero Marta Paniagua Jose Iglesias Blanca Hernandez Maria Sanz | 2014 | 催化学报2014，35，5： | 4 |
| 3 | Incidence and predictors of coronary stent thrombosis: Evidence from an international collaborative meta-analysis including 30 studies, 221,066 patients, and 4276 thromboses显示文摘 | Fabrizio D’Ascenzo Mario Bollati Fabrizio Clementi Davide Castagno Bo Lagerqvist Jose M. de la Torre Hernandez Juri?n M. ten Berg Bruce R. Brodie Philip Urban Lisette Okkels Jensen Gabriel Sardi Ron Waksman John M. Lasala Stefanie Schulz Gregg W. Stone Fl | 2013 | International Journal of Cardiology2013，，： | 1 |
| 4 | Dividing wall distillation columns: optimization and control Properties 显示文摘 | FERNANDO I Gomez-Castro JUAN GABRIEL Segovia- Hernandez SALVADOR Hernandez | 2008 | Chemical Engineering & Technology2008，31，9： | 1 |
| 5 | Thermodynami- cally equivalent distillation schemes to the Petlyuk co- lumn for ternary mixtures 显示文摘 | SALVADOR Hernandez JUAN GABRIEL Segovia-Her- nandez VICENTE Rico-Ramirez | 2006 | Energy2006，31，12： | 1 |
| 6 | Dividing wall distillation col- umns: optimization and control properties 显示文摘 | Fernando I Gomez-Castro Juan Gabriel Segovia-Heman- dez Salvador Hernandez | 2008 | Chemical Engineering & Technology2008，51，9： | 1 |
| 7 | Implementation and operation of a dividing-wall distillation column 显示文摘 | Fabricio Omar Barroso-Munoz Salvador Hernandez Juan Gabriel Segovia-Hernandez | 2011 | Chemical Engi- neering & Technology2011，34，5： | 1 |
| 8 | Thermomechanical and rheological asphalt modification using styrene-butadiene triblock copolymers with different microstructure显示文摘 | Gabriel Hernandez Eva M Medina Ricardo Sanchez | 2006 | Energy Fuels2006，20，5： | 1 |
| 9 | Investigation of Chemical Bath Deposition of ZnO Nanocrystals Thin Films Using Different ZnNO3 Concentration显示文摘 | Miguel Hemandez Hernandez Martin Lazcano Hernendez Juan Hernandez Tecorralcol Gabriel Juarez Diaz Melissa Chavez Portillo Salvador Rosas Castilla L. Chaltel Lima Oscar Portillo Moreno | 2012 | 材料科学与工程(中英文A版)2012，2，5： | 0 |
| 10 | 史密森南广场园区规划显示文摘通过与史密森学会、当地居民以及决策者的密切合作,我们为南广场园区制定了总体规划,作为对旧与新的重新诠释——方案利用园区内的现有元素,在严格监管与历史保护的限制中寻求自由。该提案旨在提升并扩大游客服务和教育空间,在博物馆与花园之间建立清晰的入口和联系,并取代已达到使用寿命的老化建筑机械系统。 | Aaron Hales Alana Goldweit Alexandre Hamlyn Andriani Atmadja Annette Miller Benjamin DiNapoli Benjamin Novacinski Cadence Bayley Choonghyo Lee Chris Falla Daisy Zhong Daniele Pronesti Doug Stechschulte Emily Chen Gabriel Hernandez Solano Janice Rim Jennifer Shen Jeremy Alain Siegel Jihoon Hyun Julian Andres Ocampo Salazar Kalina Pilat Katarzyna Starczewska Lina Bondarenko Mahsa Malek Manon Otto Martin Voelkle Ola Hariri Otilia Pupezeanu Saecheol Oh Sara Ibrahim Stephen Kwok Stephen Steckel Suemin Jeon Tammy Teng Taylor Fulton Tianqi Zhang Vincent Fulia Wells Barber Wesley Chiang Zhifei Xu 陈子钰(译) | 2019 | 城市环境设计2019，0，2： | 0 |
| 11 | 温哥华公寓显示文摘温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的'温哥华主义'建筑的全新解读,配合一座纤细的塔楼,试图保留城市视觉通廊并激活步行通道。住宅塔楼借助高度和毗邻河流的地理位置,是唯一可以同时享受水景和山景的建筑,坐拥温哥华广袤的自然风光。 | Carl McDonald Melissa Bauld Aaron Mark Alan Tansey Alex Wu Alexandra Gustafsson Alina Tamosiunaite Amina Blacksher Aran Coakley Arash Adel Ahmadian Armen Menendian Barbora Srpkova Ben Zunkeler Benjamin Caldwell Benjamin Novacinski Bennett Gale Birk Daugaard Blake Theodore Smith Brian Foster Brian Rome Carolien Schippers Christopher James Malcolm Jr. Christopher Junkin Christopher Tron David Brown David Dottelonde Deborah Campbell Doug Stechschulte Douglass Alligood Edward Yung Elena Bresciani Filip Milovanovic Francesca Portesine Gabriel Hernandez Solano Gabriel Jewell-Vitale Hector Garcia Ivy Hume Jan Leenknegt Janice Rim John Kim Josiah Poland Julian Liang Julianne Gola Julie Kaufman Karol Bogdan Borkowski Kurt Nieminen Lauren Turner Lorenz Krisai Lucio Santos Marcella Martinez Martin Voelkle Matthew Dlugosz Megan Ng Michael Robert Taylor Otilia Pupezeanu Paula Domka Phillip MacDougall Ryan Yang Sean Franklin Sebastian Grogaard Simon Scheller Spencer Hayden Taylor Fulton Terrence Chew Terry Lallak Thomas Smith Tianqi Zhang Tobias Hjortdal Tran Le Valentina Mele Xinyu Wang Yaziel Juarbe Yoanna Shivarova Zach Walters Zhifei Xu Andrew Latreille Glotman Simpson Urban YVR 运小红(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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