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| 1 | Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)represents a global health problem.Infections with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this tumor.Regardless of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis.Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence motifs.Here,we summarize the current literature implicating galectins in the pathogenesis of HCC.Expression of'proto-type'galectin-1,'chimera-type'galectin-3 and'tandem repeat-type'galectin-4 is up-regulated in HCC cells compared to their normal counterparts.On the other hand,the'tandemrepeat-type'lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes.The abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor prognosis.Moreover,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take place.Galectin-based therapies have been proposed to attenuate liver pathologies.Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC. | María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F Troncoso | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 2 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 3 | Anthocyanin pigments of sweet potatoes-Ipomoea batatas显示文摘 | Shi Z Bassa I A Gabriel S L | 1992 | Journal of Food Science1992，57，75： | 1 |
| 4 | House Price Differen- tials and Dynamics Evidence from the Los Angeles and San Francisco Metropolitan Areas 显示文摘 | Gabriel A S Mattey P J Wascher W L | 1999 | Economic Review-Federal Reserve Bank of San Francisco1999，，1： | 1 |
| 5 | Prediction of firmness and soluble solids content of blueberries using hyperspectral reflectance imaging显示文摘 | GABRIEL A L LU R F AGUILERA J M | 2013 | Journal of Food Engineering2013，115，： | 1 |
| 6 | Anthocyanin pigments of sweet-potatoes-ipomoea-batatas 显示文摘 | Shi Z L Bassa I A Gabriel S L | 1992 | Journal of Food Science1992，57，3： | 1 |
| 7 | A novel metabolic pathway for degradation of 4-nonylphenol environmental contaminants by Sphingomonas xenophaga Bayram: ipso-hydroxylation and intramolecular rearrangement 显示文摘 | GABRIEL F L P HEIDLBERGER A RENTSCH D | 2005 | Journal of Biological Chemistry2005，280，15： | 1 |
| 8 | Complications and pa- tient satisfaction after periacetabular pelvic osteotomy显示文摘 | Biedermann R Donnan L Gabriel A | 2008 | Int Orthop2008，32，5： | 1 |
| 9 | IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression显示文摘 | Fragale A Gabriele L Stellacci E | | 0，，03： | 1 |
| 10 | Response of mid-water common reed stands to water level variation and winter conditions in lake Poygan, Wisconsin, USA 显示文摘 | Bodensteiner L R Gabriel A O | 2003 | Aquatic Botany2003，76，1： | 1 |
| 11 | Complications and patient satisfaction after periacetabular pelvic osteotomy显示文摘 | Biedermann R Donnan L Gabriel A | 2008 | Int Orthop2008，32，5： | 1 |
| 12 | Diterpenoid alkaloids from Delphinium pictum Willd显示文摘 | GABRIEL D L F RAFAEL D A TOMAS O | 1989 | Heterocycles1989，29，2： | 1 |
| 13 | Microtubule-interfering activi- ty of parthenofide 显示文摘 | Miglietta A Bozzo F Gabriel L | 2004 | Chem Biol Interact2004，149，23： | 1 |
| 14 | Virtual teams:a review of current literature and directions for future research显示文摘 | POWELL A GABRIELE P BLAKE L | | 0，，01： | 1 |
| 15 | Retinal microvascularisation abnormalities and cardiovascular risk显示文摘 | Léa Mimoun Pascale Massin Gabriel Steg | 2009 | Archives of Cardiovascular Diseases2009，，5： | 1 |
| 16 | Nursing Issues in Caring for Children with Moyamoya Vasculopathy and Their Families显示文摘 | Selina Y Gabrielle A Daune L | 2007 | Journal of Neuroscience Nursing2007，39，1： | 1 |
| 17 | Direct medical costs attributable to osteoporotic fractures显示文摘 | GABRIEL S E TOSTESON A N LEIBSON C L | 2002 | Osteoporos Int2002，13，4： | 1 |
| 18 | Mus- cle activation patterns in subjects with and without low back pain 显示文摘 | NEWCOMER K L JACOBSON T D GABRIEL D A | 2002 | Archives of Physical Medicine and Rehabilitation2002，83，6： | 1 |
| 19 | House Price Differentials and Dynamics Evidence from the Angeles and San Franiso Metropolitan Areas显示文摘 | Gabriel S A Mattey J P Wascher W L | 1999 | Economic Review1999，322，： | 1 |
| 20 | Anthocyanin pigments of sweet potatoes显示文摘 | Shi Z L Bassa I A Gabriel S L | 1992 | Food Sci1992，57，3： | 1 |
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