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| 1 | ddRAD sequencing-based genotyping for population structure analysis in cultivated tomato provides new insights into the genomic diversity of Mediterranean‘da serbo’type long shelf-life germplasm显示文摘Double digest restriction-site associated sequencing(ddRAD-seq)is a flexible and cost-effective strategy for providing in-depth insights into the genetic architecture of germplasm collections.Using this methodology,we investigated the genomic diversity of a panel of 288 diverse tomato(Solanum lycopersicum L.)accessions enriched in‘da serbo’(called‘de penjar’in Spain)long shelf life(LSL)materials(152 accessions)mostly originating from Italy and Spain.The rest of the materials originate from different countries and include landraces for fresh consumption,elite cultivars,heirlooms,and breeding lines.Apart from their LSL trait,‘da serbo’landraces are of remarkable interest for their resilience.We identified 32,799 high-quality SNPs,which were used for model ancestry population structure and non-parametric hierarchical clustering.Six genetic subgroups were revealed,clearly separating most‘da serbo’landraces,but also the Spanish germplasm,suggesting a subdivision of the population based on type and geographical provenance.Linkage disequilibrium(LD)in the collection decayed very rapidly within<5 kb.We then investigated SNPs showing contrasted minor frequency allele(MAF)in‘da serbo’materials,resulting in the identification of high frequencies in this germplasm of several mutations in genes related to stress tolerance and fruit maturation such as CTR1 and JAR1.Finally,a mini-core collection of 58 accessions encompassing most of the diversity was selected for further exploitation of key traits.Our findings suggest the presence of a genetic footprint of the‘da serbo’germplasm selected in the Mediterranean basin.Moreover,we provide novel insights on LSL‘da serbo’germplasm as a promising source of alleles for tolerance to stresses. | Salvatore Esposito Teodoro Cardi Gabriele Campanelli Sara Sestili María JoséDíez Salvador Soler Jaime Prohens Pasquale Tripodi | 2020 | Horticulture Research2020，7，1： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Paradoxical sleep deprivation increases plasma endothelin levels 显示文摘 | Palma B D Gabriel A Bignotto M | 2002 | Braz J Med Biol Res2002，35，1： | 1 |
| 4 | Retrofitting existing chemical scrubbers to biotrickling filters for H2S emission control 显示文摘 | Gabriel D A M Deshusses | 2003 | Proceedings of the National Academy of Science of the United States of America2003，100，11： | 1 |
| 5 | Absence of Brea2 causes genome instability by chromosome breakage and loss associated with centrosome amphfication 显示文摘 | Tutt A Gabriel A Bertwistle D | 1999 | Curt Biol1999，9，19： | 1 |
| 6 | Effect of internal recycle on the nitrogen removal efficiency of an anaerobic/anoxic/oxic (A2/O) wastewater treatment plant (WWTP) 显示文摘 | Baeza J A Gabriel D Lafuente J | 2004 | Process Biochemistry2004，39，： | 1 |
| 7 | A novel metabolic pathway for degradation of 4-nonylphenol environmental contaminants by Sphingomonas xenophaga Bayram: ipso-hydroxylation and intramolecular rearrangement 显示文摘 | GABRIEL F L P HEIDLBERGER A RENTSCH D | 2005 | Journal of Biological Chemistry2005，280，15： | 1 |
| 8 | Experimental results on the implementation of Modelica using DEVS modeling and simulation 显示文摘 | D' Abreu Mariana C Wainer Gabriel A | 2006 | simulation2006，38，1： | 1 |
| 9 | The traffic equilibrium problem with nonadditive path costs显示文摘 | Gabriel S A Bernstein D | 1997 | Transportation Science1997，31，4： | 1 |
| 10 | Corrosion protection of low carbon steel with polyaniline: passivation or inhibition 显示文摘 | COOK A GABRIEL A SIEW D | 2004 | Current Applied Physics2004，4，24： | 1 |
| 11 | Corrosion protection of low carbon steel with polyaniline:passivation or inhibition显示文摘 | COOK A GABRIEL A SIEW D | | 0，，2： | 1 |
| 12 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 13 | A comparative study based on physical characteristics of suitable packing materials in biofihration 显示文摘 | Dorado A D Lafuente F J Gabriel D | 2010 | Environmental Technology2010，31，2： | 1 |
| 14 | Corrosion protection of low carbon steel with polyaniline: passivation or inhibition显示文摘 | Cook A Gabriel A Siew D | 2004 | Current Applied Physics2004，4，： | 1 |
| 15 | Improving the nitrogen removal efficiency of A^2/O based WWTP by using an on-line knowledge expert system 显示文摘 | Baeza J A Gabriel D Lafuente J | 2002 | Water Research2002，36，： | 1 |
| 16 | Diterpenoid alkaloids from Delphinium pictum Willd显示文摘 | GABRIEL D L F RAFAEL D A TOMAS O | 1989 | Heterocycles1989，29，2： | 1 |
| 17 | Apoptosis in u- terine epithelium and decidua in response to implantation:evidence for two different pathways 显示文摘 | JOSWIG A GABRIEL H D KIBSCHULL M | 2003 | Reprod Biol Endocrinol2003，1，1： | 1 |
| 18 | Effect of internal recycle on the nitrogen removal efficiency of an anaerobic/anoxic/oxic(A2/O) waste water treatment plant(wwtp)显示文摘 | Baeza J A Gabriel D Lafuente J | 2004 | Process Biochemistry2004，39，11： | 1 |
| 19 | Delayed ripening of 'Bartlett' pears treated with nitric oxide显示文摘 | GABRIEL O S GUSTAVO D T ADELA A F | 2003 | Journal of Horticultural Science and Biotechnology2003，78，6： | 1 |
| 20 | Neural Adaptations to Fatigue:Implications for Muscle Strength and Training显示文摘 | GABRIEL D A J R BASFORD K-N AN AN | 2001 | Med Sci Sports Exe2001，33，8： | 1 |
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