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| 1 | Patients with hematological malignancies and serological signs of prior resolved hepatitis B显示文摘Hepatitis B virus (HBV) infection affects a large part of the world population. Within the different virological HBV categories that have been identified, patients with occult HBV infection represent a peculiar group. These individuals harbor a replication competent virus, inhibited in its replicative function. Accordingly, cases of reactivations have been observed in immunosuppressed individuals who lose immunological control over the infection. Patients with hematological malignancies (HM) are treated with intense myeloand immunosuppres-sive chemotherapy regimens which favor HBV reactivation. This event can have severe consequences, such as hepatitis flare, hepatic failure and even death. In addition, it can lead to delays or interruptions of curative treatments, resulting in a decreased disease free and overall survival. In this review, we will examine the event of HBV reactivation in patients with signs of resolved HBV infection undergoing treatment for HM and propose possible management strategies. | Massimo Marignani Elia Gigante Paola Begini Alfredo Marzano Michela di Fonzo Ilaria Deli Sara Gallina Maria Christina Cox Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，3： | 3 |
| 2 | MiR-183-5p-PNPT1 Axis Enhances Cisplatin-induced Apoptosis in Bladder Cancer Cells显示文摘Objective:It has been reported that intrinsic apoptosis is associated with the progression of bladder cancer(BC).Recent evidence suggests that polyribonucleotide nucleotidyltransferase 1(PNPT1)is a pivotal mediator involved in RNA decay and cell apoptosis.However,the regulation and roles of PNPT1 in bladder cancer remain largely unclear.Methods:The upstream miRNA regulators were predicted by in silico analysis.The expression levels of PNPT1 were evaluated by real-time PCR,Western blotting,and immunohistochemistry(IHC),while miR-183-5p levels were evaluated by qPCR in BC cell lines and tissues.In vitro and in vivo assays were performed to investigate the function of miR-183-5p and PNPT1 in apoptotic RNA decay and the tumorigenic capability of bladder cancer cells.Results:PNPT1 expression was decreased in BC tissues and cell lines.Overexpression of PNPT1 significantly promoted cisplatin-induced intrinsic apoptosis of BC cells,whereas depletion of PNPT1 potently alleviated these effects.Moreover,oncogenic miR183-5p directly targeted the 3′UTR of PNPT1 and reversed the tumor suppressive role of PNPT1.Intriguingly,miR-183-5p modulated not only PNPT1 but also Bcl2 modifying factor(BMF)to inhibit the mitochondrial outer membrane permeabilization(MOMP)in BC cells.Conclusion:Our results provide new insight into the mechanisms underlying intrinsic apoptosis in BC,suggesting that the miR-183-5p-PNPT1 regulatory axis regulates the apoptosis of BC cells and might represent a potential therapeutic avenue for the treatment of BC. | Qing-gang HU Zhi YANG Jia-wei CHEN Gallina KAZOBINKA Liang TIAN Wen-cheng LI | 2022 | Current Medical Science2022，42，4： | 2 |
| 3 | Acute - phase markers of inflammation and glomerular structure in patients with type 2 diabetes 显示文摘 | Dalla Vestra M Mussap M Gallina P | 2005 | J Am Soc Nephrol2005，16，1： | 1 |
| 4 | Extended pelvic lymph node dissection in prostate cancer: a 20-year audit in a single center 显示文摘 | Abdollah F Suardi N Gallina A | 2013 | Ann Oncol2013，24，： | 1 |
| 5 | 显示文摘 | Vionnet N Dupont S Gallina S | 2000 | Am J Hum Genet2000，67，： | 1 |
| 6 | An unusual case of 'complicated' adrenal hemorrhage显示文摘 | Gallina MR Roncati D Grassino E | 2013 | Minerva Pediatr2013，65，4： | 1 |
| 7 | Mitral valve surgery for functional mitral regurgitation: should moderate-or-more tricuspid regurgitation be treated? a propensity score analysis显示文摘 | Calafiore AM Gallina S Iacb AL | 2009 | Ann Tho- rac Surg2009，87，3： | 1 |
| 8 | Dynamic model with slip for wheeled omnidirectional robots显示文摘 | CARTER B E GALLINA P | 2002 | IEEE transactions on robotics and automation2002，18，3： | 1 |
| 9 | Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes 显示文摘 | Dalla Vestra M Mussap M Gallina P | 2005 | J Am Soc Nephrol2005，16，1： | 1 |
| 10 | Guided reso-, nances in photonic crystals with point-defected ape-riodically-ordered supercells 显示文摘 | Gallina I Pisco M Ricciardi A | 2009 | Opt Express2009，17，19： | 1 |
| 11 | Neural network painting defect classification using Karhunen-Loevetransformation显示文摘 | PAOLO GALLINA | 1999 | Optics and Lasers in Engineering1999，32，1： | 1 |
| 12 | Obstructive sleep apnoea syndrome (OSAS): effects on the vestibular system显示文摘 | Gallina S Dispenza F Kulamarva G | 2010 | Acta Otorhinolaryngol Ita2010，30，6： | 1 |
| 13 | Dissipation of glufosinate ammonium in two Ontario soils显示文摘 | Gallina M A Stephenson G R | 1992 | Agric Food chem1992，40，： | 1 |
| 14 | Design and testing of a 5-degrees-of freedom,large working range micropositioning stage显示文摘 | Scuor N Gallina P | | 0，，04： | 1 |
| 15 | Delayed reference control for hotwire cutting of expandable polystyrene foam 显示文摘 | Gallina | 2006 | Journal of Manufacturing Science and Engineering Transactions of the ASME2006，128，1： | 1 |
| 16 | Variation in FTO contributes to childhood obesity and severe adult obesity 显示文摘 | DINA C MEYRE D GALLINA S | 2007 | Nature Genetics2007，39，5： | 1 |
| 17 | Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1 , 25 - dihydroxyvitamin D3 levels during management of thyrotoxicosis 显示文摘 | IQBAL A A BURGESS E H GALLINA D L | 2003 | Endocr Pract2003，9，6： | 1 |
| 18 | Predicting the riskof bone metastasis in prostate cancer显示文摘 | Briganti A Suardi N Gallina A | 2014 | Cancer Treat2014，40，1： | 1 |
| 19 | Heparinbinding activity of orf virus F1L protein显示文摘 | Scagliarini A Gallina L Dal Pozzo F A | 2004 | Virus Re~2004，105，2： | 1 |
| 20 | Optimizing dissolved air flotation design and saturation显示文摘 | Feris L A Gallina C W Rodrigues R T | 2001 | Water Science and Technology2001，43，8： | 1 |
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