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| 1 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 2 | Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital显示文摘AIM:To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients.METHODS:In total,789 consecutive outpatients referred for gastrointestinal(GI) endoscopy [381 for esophagogastroduodenoscopy(EGD) and 408 for colonoscopy] were prospectively enrolled in the study.The American Society for Gastrointestinal Endoscopy(ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic f indings.RESULTS:The overall inappropriate rate was 13.3%.The indications for EGD and colonoscopy were,respectively,appropriate in 82.7% and 82.6% of the exams,uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%.The diagnostic yield was signif icant higher forEGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate(EGD:36.6% vs 36.4% vs 11.4%,P = 0.004;Colonoscopy:24.3% vs 20.0% vs 3.3%,P = 0.001).Of the 25 malignant lesions detected,all but one was detected in exams judged appropriate or uncertain.CONCLUSION:This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations,namely in detecting neoplastic lesions.It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures. | Joo Mangualde Marie I Cremers Ana M Vieira Ricardo Freire lia Gamito Cristina Lobato Ana L Alves Fátima Augusto Ana P Oliveira | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 2 |
| 3 | An Accurate Model of Wave Refraction over Shallow Water 显示文摘 | Manuel N Gamito F Kenton Musgrave | 2002 | Computer Graphics (S0097-8930)2002，26，2： | 1 |
| 4 | Trophic food web and ecosystem at-tributes of a water reservoir of the Ria Formosa(South Por-tugal)显示文摘 | Gamito S Erzini K | 2005 | Ecological Modelling2005，181，： | 1 |
| 5 | Accurate multidimensional Poisson -disk sampling 显示文摘 | GAMITO M N MADDOCK S C | 2009 | ACM Trans Graphic2009，29，： | 1 |
| 6 | Progressive refinement rendering of implicit surfaces显示文摘 | Gamito M N Maddock S C | 2007 | Computers & Graphics2007，31，5： | 1 |
| 7 | Growth models and their use in ecological modelling:An application to a fish population显示文摘 | Gamito S | | 0，，： | 1 |
| 8 | A discretised linear elastic model for cloth buckling and drape 显示文摘 | DISS J M S GAMITO M N | 2000 | Textile Res J2000，70，4： | 1 |
| 9 | Ray casting implicit fractal surfaces with reduced affine arithmetic 显示文摘 | Gamito M N Maddock S C | 2007 | The Visual Computer2007，23，3： | 1 |
| 10 | Feedingdiversityindexascomplementaryinformationintheassessmentofecologicalquality status显示文摘 | GamitoS PatrícioJ NetoJ etal | 2012 | EcologicalIndicators2012，19，： | 1 |
| 11 | An accurate model of wave refraction over shallow water显示文摘 | Gamito M N Musgrave F K | 2002 | Computers &Graphics2002，26，2： | 1 |
| 12 | Ray casting implicit fractal surfaces with reduced affine arithmetic显示文摘 | Gamito M N Maddock S C | 2007 | The Visual Computer2007，23，3： | 1 |
| 13 | Growth models and their use in ecological modelling:An application to a fish population 显示文摘 | Gamito S | 1998 | Ecological Modelling1998，113，13： | 1 |
| 14 | Synthesis and antifungal activity of terpenyl-1,4-naphthoquinone and 1,4-anthracenedione derivatives显示文摘 | Mngeles Castro A M Gamito V Tangarife-Castano | 2013 | European Journal of Medicinal Chemistry2013，67，： | 1 |
| 15 | Two-dimensional simulation of gaseous phenomena using vortex particles 显示文摘 | Gamito M N Comes M R | 1995 | Computer Animation and Simulation1995，，： | 1 |
| 16 | Herbal and vitamin supplement use in a prostate cancer screening population显示文摘 | Barqawi Albaha Gamito Eduard O'Donnell Colin | 2004 | Urology2004，63，2： | 1 |
| 17 | A discretised linear elastic model for cloth buckling and drape 显示文摘 | DISS J M S GAMITO M N | 2000 | Textile Res J2000，70，4： | 1 |
| 18 | Colorectal cancer screening:A review of current knowledge and progress in research显示文摘Colorectal cancer(CRC)is one of the most prevalent malignancies worldwide,being the third most commonly diagnosed malignancy and the second leading cause of cancer-related deaths globally.Despite the progress in screening,early diagnosis,and treatment,approximately 20%-25%of CRC patients still present with metastatic disease at the time of their initial diagnosis.Furthermore,the burden of disease is still expected to increase,especially in individuals younger than 50 years old,among whom early-onset CRC incidence has been increasing.Screening and early detection are pivotal to improve CRC-related outcomes.It is well established that CRC screening not only reduces incidence,but also decreases deaths from CRC.Diverse screening strategies have proven effective in decreasing both CRC incidence and mortality,though variations in efficacy have been reported across the literature.However,uncertainties persist regarding the optimal screening method,age intervals and periodicity.Moreover,adherence to CRC screening remains globally low.In recent years,emerging technologies,notably artificial intelligence,and non-invasive biomarkers,have been developed to overcome these barriers.However,controversy exists over the actual impact of some of the new discoveries on CRC-related outcomes and how to effectively integrate them into daily practice.In this review,we aim to cover the current evidence surrounding CRC screening.We will further critically assess novel approaches under investigation,in an effort to differentiate promising inno-vations from mere novelties. | Sara Ramos Lopes Claudio Martins Inês Costa Santos Madalena Teixeira Élia Gamito Ana Luisa Alves | 2024 | World Journal of Gastrointestinal Oncology2024，16，4： | 0 |
| 19 | 推动蓝色金融,保护江河湖海显示文摘海洋和水系对人类生存至关重要,蓝色经济是全球经济的基石。超过30多亿人的食物、工作和生计依赖海洋。然而,气候变化、过度捕捞和污染正使我们的海洋面临巨大风险,并危及全球经济的可持续发展。同时,发展可持续蓝色经济,包括防止海洋渔业衰退、扩大低碳水产养殖以及海上可再生能源的规模化、海洋运输的脱碳,对于人类共同应对气候迅速变化、自然损失和污染的三重全球危机意义重大。海洋作为重要的热量和碳汇聚集地,吸收了约31%的二氧化碳排放量,有利于全球气候的调节。在推动全球经济体系转型、着力保护和增加清洁水资源、重建海洋繁荣、恢复生物多样性和重塑海洋健康方面,金融机构发挥着重要作用。蓝色金融蕴含着巨大潜力,助力包括中国在内的众多国家和地区实现碳中和等重要发展目标。 | 朱韵 Pushkala Lakshmi Ratan Jose Gamito Pires | 2023 | 中国信用卡2023，，10： | 0 |
| 20 | Systemic mastocytosis: A rare cause of non-cirrhotic portal hypertension显示文摘Mastocytosis is a clonal neoplastic disorder of the mast cells(MC) that can be limited to the skin(cutaneous mastocytosis) or involve one or more extracutaneous organs(systemic mastocytosis). The clinical manifestations of mastocytosis are heterogeneous ranging from indolent disease with a long-term survival to a highly aggressive neoplasm with survival of about 6 mo. Although liver involvement in aggressive systemic mastocytosis(ASM) is relatively common, the development of portal hypertension with or without cirrhosis is rare. We report a case of ASM without skin involvement in a 72-year-old caucasian male who presented with non-cirrhotic portal hypertension based on clinical, analytical, imagiological and endoscopic findings. Given the hematological picture, the correct diagnosis was established based on ancillary tests for MC using bone marrow aspirates and biopsy. Extensive involvement of the liver and gastrointestinal tract was histologically documented. The disease progressed rapidly and severe pancytopenia and recurrent upper gastrointestinal bleeding became the dominant problem. This case illustrates the challenge in establishing a diagnosis of ASM especially when the clinical picture is atypical and without skin involvement. Gastroenterologists should consider infiltrative disease, particularly systemic mastocytosis, as a differential diagnosis in a clinical case of portal hypertension of unknown etiology. | Cláudio Martins Cristina Teixeira Suzane Ribeiro Daniel Trabulo Cláudia Cardoso Joao Mangualde Ricardo Freire élia Gamito Ana Luísa Alves Isabelle Cremers Cecília Alves Anabela Neves Ana Paula Oliveira | 2016 | World Journal of Gastroenterology2016，22，28： | 0 |
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