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| 1 | Laboratory Investigation of Disintegration Characteristics of Purple Mudstone under Different Hydrothermal Conditions显示文摘Disintegration of rock is one of the primary processes of soil formation and geomorphology and is affected considerably by water and heat.This study focused on the disintegration characteristics under laboratory conditions of typical purple mudstone from the Tuodian group of Jurassic red beds(J3t) in Tuodian Town,Shuangbai county,Yunnan Province of southern China.The fresh mudstone was subjected to alternating applications of water,heat and hydrothermal interaction during five treatments:wetting-drying(WD),saturation(ST),refrigeration-heating(RH),a combination of wetting-drying and refrigeration-heating(WDRH),and a combination of saturation and refrigeration-heating(STRH).Each treatment was run in twenty-four cycles.The results showed that there are three types of disintegration:collapsing disintegration,exfoliation disintegration and imperceptible disintegration.The cumulative disintegration rate(percentage of cumulative disintegrated mass to the initiative sample mass passed through a 2 mm sieve) produced a 'S'-shape function when related to treatment cycle time and closely fit a logistic model(R2 > 0.99).The rank order of the cumulative disintegration rate resulting from the five treatments was as the following:WDRH > STRH > ST > WD > RH.Because of alternating periods of moisture and dryness,WD caused the most disintegration,while RH alone resulted in imperceptible disintegration.Additionally,there was a negative correlation between the disintegration rate of each treatment cycle(percentage of disintegrated mass to the treated sample mass) and treatment cycle number.There was a positive correlation between this rate and temperature change under moist conditions,indicating that a change in temperature greatly accelerates the disintegration of parent rock when water was supplied. | ZHANG Dan CHEN Anqiang LIU Gangcai | 2012 | Journal of Mountain Science2012，9，1： | 17 |
| 2 | Mercury indicating inflow zones and ruptures along the Wenchuan Ms 8.0 earthquake fault显示文摘During the Wenchuan Fault Scientific Drilling Project,we determined the values of total mercury(HgT)and gaseous elemental mercury(GEM) from drilled cores and drilling mud,respectively.Geochemical analysis shows HgT values ranging from 0.24 to 6.45 ng/g for the Penguan complex and from 2.90 to 137.54 ng/g for T3 sediment.The average levels of HgT for the Penguan complex and T3 sediments are 1.81 ± 0.26 ng/g and23.96 ± 4.80 ng/g,respectively.Major anomalous peaks of HgT appear at depth of 614,731,993 and 1,107 m,which correspond to the long-term high seismic activity during crustal deformation in response to tectonic stresses.Gaseous elemental mercury dissolved in drilling mud was also analyzed.We found fluid inflow zones with high GEM at depths of 590-750 m,suggesting that fluid-filled ruptures exist in the LMS fault zone.It indicates that mercury provides geochemical evidence for inflow zones and ruptures/fault zones in the Wenchuan Ms 8.0 earthquake fault. | Yang Duoxing Zhang Lei Liu Yaowei Ren Hongwei Xie Furen Chen Gangcai | 2015 | Chinese Journal Of Geochemistry2015，34，2： | 5 |
| 3 | BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis显示文摘As a BET bromodomain inhibitor, JQ1 has been proven have efficacy against a number of different cancers. In terms of male reproduction, JQ1 may be used as a new type of contraceptive, since JQ1 treatment in male mice could lead to germ cell defects and a decrease of sperm motility, moreover, this effect is reversible. However, the mechanism of JQ1 acting on gene regulation in spermatogenesis remains unclear. Here, we performed single-cell RNA sequencing (scRNA-seq) on mouse testes treated with JQ1 or vehicle control to determine the transcriptional regulatory function of JQ1 in spermatogenesis at the single cell resolution. We confirmed that JQ1 treatment could increase the numbers of somatic cells and spermatocytes and decrease the numbers of spermatid cells. Gene Ontology (GO) analysis demonstrated that differentially expressed genes which were down-regulated after JQ1 injection were mainly enriched in “DNA conformation change” biological process in early developmental germ cells and “spermatid development” biological process in spermatid cells. ATAC-seq data further confirmed that JQ1 injection could change the open state of chromatin. In addition, JQ1 could change the numbers of accessible meiotic DNA double-stranded break sites and the types of transcription factor motif that functioned in pachytene spermatocytes and round spermatids. The multi-omics analysis revealed that JQ1 had the ability to regulate gene transcription by changing chromatin conformation in mouse spermatogenesis, which would potentiate the availability of JQ1 in male contraceptive. | Xiaorong Wang Mengmeng Sang Shengnan Gong Zhichuan Chen Xi Zhao Guishuan Wang Zhiran Li Yingying Huang Shitao Chen Gangcai Xie Enkui Duan Fei Sun | 2022 | Genes & Diseases2022，9，4： | 1 |
| 4 | Distribution of heavy metals in an incineration system of solid wastes in the Three-Gorges region of the Yangtze River显示文摘On the basis of investigations on the composition and contents of heavy metals in the domestic refuse in the Three-Gorges region of the Yangtze River, in combination with the experimental results, this paper deals with the distribution rule of heavy metals in the various compartments of an incineration system:leachate pool, fly ash and residue. It is concluded that in the leachate pool heavy metals should not be neglectable since about 30% of Pb and 10% of Cr are leached here; in the incineration system, above 74% of Cr, As and Pb exists in residue; above 96% of Hg exists in fly ash and the contents of Cd in fly ash are close to those of residue. It is also concluded that the physical conditions of incineration have a significant influence on the distribution of heavy metals in the incineration system. | HUANG Chuan WANG Li' ao CHEN Gangcai LUO Yu ZHANG Jun CUI Zhiqiang | 2008 | Chinese Journal Of Geochemistry2008，27，2： | 1 |
| 5 | Microenvironmental time-activity patterns in Chongqing,China显示文摘An investigation using recall questionnaires was conducted in winter and autumn 2006 to evaluate the time-activity patterns in Chongqing,China.The average time spent in seven microenvironments(MEs)including outdoors,transit,living room,bedroom,kitchen,classroom/office,and other indoors were found to be about 3.5,1.1,2.5,9.7,1.4,4.2,and 1.7 h per day,respectively.According to the results of a nonparametric test,the sampling period and day of week were significant for the variation of the time spent in all MEs except for transit and outdoors.The time budget was analyzed using a general linear model(GLM),which exhibited significant variability by demographic factors such as gender,age,residence,education,and household income. | Yu ZHAO Shuxiao WANG Gangcai CHEN Fei WANG Kristin AUNAN Jiming HAO | 2009 | Frontiers of Environmental Science & Engineering2009，3，2： | 1 |
| 6 | Estimated Public Health Exposure to H2S Emissions from a Sour Gas Well Blowout in Kaixian County,China显示文摘 | Gangcai Chen Renjian Zhang | 2006 | Aerosol and Air Quality Research2006，6，4： | 1 |
| 7 | Health risk assessment for typical and abandoned chromium-contaminated sites显示文摘Chromium pollution were investigated by sampling the abandoned chromium contaminated sites in Chongqing. Its health risk was assessed following the procedures made by USEPA. The results showed that the most seriously polluted land was found at the former production area(G4) with average Cr(VI) concentration of 3369.2 mg·kg-1 on the surface soil. The assessment indicated that there was high risk of non-carcinogens for children. The assessed risk of the first layer of office area(G1) for children, chromium slag transition(G2), drainage pipeline chromium slag transition(G3) and production area(G4) for both children and adults were not acceptable(>1.00×10-6). It was strongly suggested that the accessible measures of remediation should be taken for a portion of contaminated sites before the reuse of abandoned lands. | DENG Hongyan CHEN Gangcai | 2014 | Chinese Journal Of Geochemistry2014，33，4： | 0 |
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