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您的检索式：作者名="Gangzheng Hu"
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| 1 | Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair显示文摘间充质的干细胞(MSC ) 为治疗各种各样的疾病有大潜力,特别那些与织物有关损坏包含有免疫力的反应。各种各样的研究证明了 MSC 在 vitro 并且在 vivo 是强烈抑制免疫力的。我们的最近的研究证明了那未刺激的 MSC 确实不能免疫力的抑制;他们与 TNF- 伪, IL-1 伪或 IL-1 尾与激活的淋巴细胞的上层清液,或与 IFN- 纬的联合在刺激之上变得 potently 抑制免疫力。这观察表明在某些情形下面,煽动性的 cytokines 能实际上变得抑制免疫力。我们证明在调停 MSC 的免疫力的抑制的机制有一个种类变化:由告知 cytokine 的老鼠 MSC 的免疫力的抑制被氮的氧化物调停(没有) 而由告知 cytokine 的人的 MSC 的免疫力的抑制通过 indoleamine 被执行 2, 3-dioxygenase (伊多语) 。在有煽动性的 cytokines 的刺激之上,另外,老鼠和人的 MSC 分泌几白血球 chemokines 显然服务与 MSC 吸引有免疫力的房间进最近,在哪儿不或伊多语被预言很活跃。因此,由煽动性的刺激 cytokine 的 MSC 的免疫力的抑制经由 chemokines 的一致行动发生并且免疫者禁止没有或伊多语由 MSC 生产了。因此,我们的结果在对待有免疫力的回答导致的织物损害关于调停 MSC 的免疫力的抑制并且为 MSC 的更好的申请的机制提供新奇信息。 | Yufang Shi Gangzheng Hu Juanjuan Su Wenzhao Li Qing Chen Peishun Shou Chunliang Xu Xiaodong Chen Yin Huang Zhexin Zhu Xin Huang Xiaoyan Han Ningxia Xie Guangwen Ren | 2010 | Cell Research2010，20，5： | 72 |
| 2 | Antigen-non-specific regulation centered on CD25^(+)Foxp3^(+) Treg cells显示文摘CD25^(+)Foxp3^(+) regulatory T cells(Tregs)are of special interest in immunology because of their potent inhibitory function.Many fundamental aspects of Tregs,including their antigenic profile,development and peripheral homeostasis,remain highly controversial.Here,we propose a Treg-centered antigen-non-specific immunoregulation model focused on the T-cell system,particularly on CD41 T cells.The T-cell pool consists of naive T cells(Tnais),Tregs and effector T cells(Teffs).Regardless of antigen specificity,the ratio of the activated T-cell subsets(Treg/Teff/Tnai)and their temporal and spatial uniformity dictate the differentiation of Tnais.Activated Tregs inhibit the activation,proliferation,induction and activity of Teffs;in contrast,activated Teffs inhibit the induction of Tregs from Tnais but cooperate with Treg-specific antigens to promote the proliferation and activity of Tregs.In many cases,these interactions are antigen-non-specific,whereas the activation of both Tregs and Teffs is antigen-specific.Memory T-cell subsets are essential for the maintenance of adaptive immune responses,but the antigen-non-specific interactions among T-cell subsets may be more important during the establishment of the adaptive immune system to a newly encountered antigen.This is especially important when new and memory antigens are presented closely—both temporally and spatially—to T cells,because there are always baseline levels of activated Tregs,which are usually higher than levels of memory T cells for new antigens.Based on this hypothesis,we further infer that,under physiological conditions,Tregs in lymph nodes mainly recognize antigens frequently released from draining tissues,and that these self-reactive Tregs are commonly involved in the establishment of adaptive immunity to new antigens and in the feedback control of excessive responses to pathogens. | Gangzheng Hu Zhongmin Liu Changqing Zheng Song Guo Zheng | 2010 | Cellular & Molecular Immunology2010，7，6： | 2 |
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