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| 1 | p63基因在肺癌组织中的表达显示文摘目的 研究肺鳞状细胞癌、腺癌、大细胞肺癌、小细胞肺癌以及淋巴结或肺内转移性肿瘤标本组织中p63基因的mRNA转录因子和蛋白表达水平,探讨p63基因表达与其定位在3q 27-q29区域改变的关系。方法 采用cDNA微阵列技术同时检测72例不同病理组织学类型的原发性肺癌(包括鳞状细胞癌、腺癌、大细胞癌、小细胞癌)和肺癌肺内转移及淋巴结转移灶内的p63基因mRNA水平。另外,利用组织芯片技术构建150例原发性肺癌石蜡包埋标本组织芯片,采用免疫组织化学LSAB法检测p63基因蛋白表达情况。同时应用比较基因组杂交(CGH)技术对70例原发性肺癌标本进行了3号染色体长臂改变的分析。结果 p63mRNA转录因子在肺鳞状细胞癌标本表达明显增强,与腺癌、大细胞癌、小细胞癌相比增多10倍以上。肺癌转移灶内p63基因mRNA表达水平明显高于其相对应的原发性灶,差异有统计学意义(P<0.001)。免疫组织化学染色结果显示:肺鳞状细胞癌阳性表达率为94.64%;腺癌是1.79%;4例大细胞肺癌中2例为阳性染色;但所有小细胞肺癌标本免疫组织化学染色均为阴性。pT1分期肺癌的p63基因蛋白表达阳性率与pT2分期肺癌相比有统计学差异(P<0.05)。比较基因组杂交结果发现:肺鳞状细胞癌3号染色体长臂27-29区域有显著的扩增,腺癌表现为缺失。鳞状细胞癌p63基因的? | 余永伟 Mitchell E Garber KarstenSchlüns ManuelaPacyna-Gengelbach IverPetersen | 2004 | 中华病理学杂志2004，33，4： | 7 |
| 2 | Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: Guidance for prescribing exercise显示文摘 | Garber C E Blissmer B Deschenes M R | 2011 | Medicine & Science in Sports & Exercise2011，43，7： | 1 |
| 3 | Differ- ences in intracellular location of pp60src in rat and chicken cells transformed by Rous sarcoma virus 显示文摘 | KRUEGER JG WANG E GARBER EA | 1980 | Proc Natl Acad Sci USA1980，77，7： | 1 |
| 4 | Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome显示文摘 | Frebourg T Barbier N Yan Y X Garber J E Dreyfus M Fraumeni J | 1995 | Am J Human Genet1995，56，： | 1 |
| 5 | The effect of heat stress on ovarian fun- ction of laying hens显示文摘 | Rozenboim E Tako 0 Garber J | 2007 | Poultry Science2007，86，： | 1 |
| 6 | Radar target identification of aircraft using polarization diverse features 显示文摘 | Chamberlain N F Walton E K Garber F D | 1991 | IEEE Trans AES1991，27，1： | 1 |
| 7 | Bald, a second allele of hairless in the house mouse 显示文摘 | Garber E D | 1952 | J Hered1952，43，： | 1 |
| 8 | Feasibility of immunodiagnostic devices for the detection of ricin, amanitin, and T-2 toxin in food显示文摘 | GARBER E A EPPLEY R M STACK M E | 2005 | Journal of Food Protection2005，68，： | 1 |
| 9 | Spontaneous cholecystocutaneous fistula presenting in the gluteal region显示文摘 | Nicholson T Born MW Garber E | 1999 | J Clin Gastroenterol1999，28，： | 1 |
| 10 | Influence of particle size on the twin-screw extrusion of corn meal显示文摘 | Garber B W Hsieh F Huff H E | 1997 | Cereal Chemistry1997，74，5： | 1 |
| 11 | Detection of ricin in food using electrochemiluminescence-based technology显示文摘 | GARBER E A O' BRIEN T W | 2008 | J AOAC Int2008，91，2： | 1 |
| 12 | Detection of abrin in foodusing enzyme-linked immunosorbent assay and electrochemilumi-nescence technologies显示文摘 | Garber E A Walker J L O'Brien T W | 2008 | Journal of Food Protection2008，71，9： | 1 |
| 13 | Detection of abrin in food using enzyme-linked immunosorbent assay and electrochemiluminescence technologies显示文摘 | GARBER E A WALKER J L O'BRIEN T W | 2008 | J Food Prot2008，71，9： | 1 |
| 14 | Nonparametric methods for identifying differentially expressed genes in microarray data显示文摘 | Troyanskaya Olga G Garber Mitchell E Brown Patrick O | 2002 | Bioinformatics2002，18，11： | 1 |
| 15 | Radar target iden- tification using the bispectrum: a comparative study 显示文摘 | JOUNY I GARBER E D MOSES R L | 1995 | 1EEE Transactions on Aerospace and Electronic Systems1995，31，1： | 1 |
| 16 | Avian cells expressing the murine protein are resistant to influenza infection显示文摘 | Garber E A | 1991 | Virology1991，180，： | 1 |
| 17 | Detection of melamine using commercial enzyme linked immunosorbent assay technology 显示文摘 | GARBER E A E | 2008 | Joumal of Food Protection2008，71，3： | 1 |
| 18 | Detection of melamine using commercialenzyme-linked immunosorbent assay technology显示文摘 | ERIC A GARBER E | 2008 | Journal of FoodProtection2008，71，3： | 1 |
| 19 | Does MRI predict pathologic tumor response in women with breast cancer undergoing preoperative chemotherapy显示文摘 | Partridge D Krop I E Garber J E | 2007 | Surg Oncol2007，96，6： | 1 |
| 20 | A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity,loop-specific binding to TAR RNA显示文摘 | GARBER M E FANG S M | 1998 | Cell1998，92，： | 1 |
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