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| 1 | Timing, method and discontinuation of hydrocortisone administration for septic shock patients显示文摘AIM To characterize the prescribing patterns for hydrocortisone for patients with septic shock and perform an exploratory analysis in order to identify the variables associated with better outcomes.METHODS This prospective cohort study included 59 patients with septic shock who received stress-dose hydrocortisone.It was performed at 2 critical care units in academic hospitals from June 1st, 2015, to July 31 st, 2016. Demographic data, comorbidities, medical management details, adverse effects related to corticosteroids, and outcomes were collected after the critical care physician indicated initiation of hydrocortisone. Univariate comparison between continuous and bolus administration of hydrocortisone was performed, including multivariate analysis, as well as Kaplan-Meier analysis to compare the proportion of shock reversal at 7 d after presentation. Receiver operating characteristic(ROC) curves determined the best cut-off criteria for initiation of hydrocortisone associated with the highest probability of shock reversal. We addressed the effects of the taper strategy for discontinuation of hydrocortisone, noting risk of shock relapse and adverse effects.RESULTS All-cause 30-d mortality was 42%. Hydrocortisone was administered as a continuous infusion in 54.2% of patients; time to reversal of shock was 49 h longer in patients who were given a bolus administration [59 h(range, 47.5-90.5) vs 108 h(range, 63.2-189); P = 0.001]. The maximal dose of norepinephrine after initiation of hydrocortisone was lower in patients on continuous infusion [0.19 μg/kg per minute(range, 0.11-0.28 μg)] compared with patients who were given bolus [0.34 μg/kg per minute(range, 0.16-0.49); P = 0.004]. Kaplan-Meier analysis revealed a higher proportion of shock reversal at 7 d in patients with continuous infusion compared to those given bolus(83% vs 63%; P = 0.004). There was a good correlation between time to initiation of hydrocortisone and time to reversal of shock(r = 0.80; P < 0.0001); ROC curve analysis revealed that the best criteria for prediction of shock reversal was a time to initiation of hydrocortisone of ≤ 13 h after administration of norepinephrine, with an area under the curve of 0.81(P < 0.001). The maximal dose of norepinephrine at initiation of hydrocortisone with the highest association with shock reversal was ≤ 0.28 μg/kg per minute, with an area under the curve of 0.75(P = 0.0002). On a logistic regression model, hydrocortisone taper was not associated with a lower risk of shock relapse(RR = 1.29; P = 0.17) but was related to a higher probability of hyperglycemia [odds ratio(OR), 5.3; P = 0.04] and hypokalemia(OR = 10.6; P = 0.01). CONCLUSION Continuous infusion of hydrocortisone could hasten the resolution of septic shock compared to bolus administration. Earlier initiation corresponds with a higher probability of shock reversal. Tapering strategy is unnecessary. | Miguel A Ibarra-Estrada Quetzalcóatl Chávez-Pe?a Claudia I Reynoso-Estrella Jorge Rios-Zerme?o Pável E Aguilera-González Miguel A García-Soto Guadalupe Aguirre-Avalos | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 2 | Inflammation, complement, ischemia and amoebic survival in acute experimental amoebic liver abscesses in hamsters显示文摘 | A Olivos-Garc??a M Nequiz-Avenda?o E Tello R.D Mart??nez A González-Canto R López-Vancell M.C Garc??a de León I Montfort R Pérez-Tamayo | 2004 | Experimental and Molecular Pathology2004，，1： | 1 |
| 3 | Long-term (5 years) effects of bosentan in patients with pulmonary arterial hypertension 显示文摘 | Avellana P Segovia J Sufrate E Gómez-Bueno M García-Cosío Carmena M D García-Pavía P | 2011 | Rev Esp Cardiol2011，64，： | 1 |
| 4 | A numerical model for the flooding and drying of irregular domains 显示文摘 | BRUFAU P V A ZQUEZ-CEND O N M E GARC I A-NAVARRO P | 2002 | International Journal for Numerical Methods in Fluids2002，39，3： | 1 |
| 5 | Antiphospholipid syndrome and asymptomatic carriers of antiphospholipid antibody:prospective analysis of 404 individuals显示文摘 | Girón-Gonzólez JA García del Río E Rodríguez C | 2004 | J Rheumatol2004，31，： | 1 |
| 6 | Regular Black Hole in General Relativity Coupled to Nonlinear Electrodynamics显示文摘 | AY(O)N-BEATO E GARC(I)A A | 1998 | Physical Review Letters1998，80，23： | 1 |
| 7 | Effect of carbon fibers on the mechanical properties and cmTosion levels of reinforced portland cement mortars 显示文摘 | Garces P Fraile E J Vilaplana O | 2005 | Cement and Concrete Research2005，35，2： | 1 |
| 8 | Treatment of gynecomastia in patients with prostate cancer and androgen deprivation显示文摘 | Bautista-Vidal C Barnoiu O García-Galisteo E | 2013 | Actas Urol Esp2013，11，： | 1 |
| 9 | The Bardeen Model as a Nonlinear Magnetic Monopole显示文摘 | AY(O)N-BEATO E GARC(I)A A | 2000 | Physics Letters B2000，493，12： | 1 |
| 10 | Primary intraosseoushemangioma of the orbit:report of two cases显示文摘 | Torres-Carranza E García-Perla A Infante-Cossío P | | 0，，04： | 1 |
| 11 | HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium显示文摘BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence factor.AIM To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) cells.METHODS Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional modeling.RESULTS HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium cells.Immunogold technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS cells.Bioinformatics analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein to the external environment. The programs also showed a similarity with the Tip-alpha protein of H. pylori. Tip-alpha is an exotoxin that penetrates cells and induces tumor necrosis factor alpha production, and HP0953 could have a similar function as posttranslational modification sites were found;modifications in turn require enzymes located in eukaryotic cells. Thus, to be functional, HP0953 may necessarily need to be translocated inside the cell where it can trigger different mechanisms producing cellular damage.CONCLUSION The location of HP0953 around infected cells, the probable posttranslational modifications, and its similarity to an exotoxin suggest that this protein is a virulence factor. | Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García Norma Velázquez-Guadarrama | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 12 | Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy显示文摘 | SIM(O) R CARRASCO E GARC(I)A-RAM(I)REZ M | 2006 | Current Diabetes Reviews2006，2，1： | 1 |
| 13 | Flavonoids as anti-inflammatory agents:implications in cancer and cardiovascular disease显示文摘 | GARC(I)A-LAFUENTE A GUILLAM(O)N E VILLARES A | | 0，，9： | 1 |
| 14 | Saccharomyces cerevisiae signature genes for predicting nitrogen deficiency during alcoholic fermentation 显示文摘 | Mendes-Ferreira A del Olmo M García-Martínez J Jiménez-Martí E Le?o C Mendes-Faia1 A Pérez-Ortín JE | 2007 | Appl Environ Microbiol2007，73，16： | 1 |
| 15 | Site preference, size effects and segregation in RuAlB alloys 显示文摘 | Mosca H O Bozzolob G Garce's J E | 2008 | Scripta Materialia2008，58，： | 1 |
| 16 | Hydrocracking of vacuum residue by homogeneous catalysis显示文摘 | JUáREZ E M GARCíA F J O HERNáNDEZ P S | 2014 | Fuel2014，135，： | 1 |
| 17 | Renal failure is a risk factor for cefepime-induced encephalopathy显示文摘 | Garces E O Andrade de Anzambuja M F da Silva D | 2008 | J Nephrol2008，21，4： | 1 |
| 18 | Muscle weakness and tolerance of low doses of rocuronium in healthy awake volunteers breathing spontaneously显示文摘 | Gerónimo Pardo M Martínez González E García Blasco O | 2009 | Rev Esp Anestesiol Reanim2009，56，4： | 1 |
| 19 | Carotenoid retention and storage stability of spray-dried encapsulated paprika oleoresin using gum Arabic and Soy protein isolate as wall materials显示文摘 | Rasc o n Martha Paola Beristain C e sar I Garc i a Hugo S | 2011 | LWT-Food Science and Technology2011，44，： | 1 |
| 20 | Macroscopic assessment of mesorectal excision in rectal cancer:a useful tool for improving quality control in a multidisciplinary team显示文摘 | García-Granero E Faiz O Mu(n)oz E | | 0，，15： | 1 |
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