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| 1 | Psychosocial mechanisms for the transmission of somatic symptoms from parents to children显示文摘AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress.METHODS:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget Sound.Mothers completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health Cooperative.Mothers with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and education.RESULTS:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in children.There was no significant correlation between parental reinforcement of symptoms and child expression of GI or other symptoms.Hypothesis 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in children.Children of parents with IBS reported more non-GI(8.97 vs 6.70,P<0.01)as well as more GI(3.24 vs 2.27,P<0.01)symptoms.Total health care visits made by the mother correlated with visits made by the child(rho=0.35,P<0.001 for cases,rho=0.26,P<0.001 for controls).Hypothesis 3:children learn to share the methods of coping with illness that their mothers exhibit.Methods used by children to cope with stomachaches differed from methods used by their mothers.Only 2/16 scales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and children share psychological traits such as anxiety,depression,and somatization.Child psychological distress correlated with mother’s psychological distress(rho=0.41,P<0.001 for cases,rho=0.38,P<0.001 for controls).Hypothesis 5:stress that affects the whole family might explain the similarities between mothers and their children.Family exposure to stress was not a significant predictor of children’s symptom reports.Hypothesis 6:the intergenerational transmission of GI illness behavior may be due to multiple mechanisms.Regression analysis identified multiple independent predictors of the child’s GI complaints,which were similar to the predictors of the child’s non-GI symptoms(mother’s IBS status,child psychological symptoms,child catastrophizing,and child age).CONCLUSION:Multiple factors influence the reporting of children’s gastrointestinal and non-gastrointestinal symptoms.The clustering of illness within families is best understood using a model that incorporates all these factors. | Miranda AL van Tilburg Rona L Levy Lynn S Walker Michael Von Korff Lauren D Feld Michelle Garner Andrew D Feld William E Whitehead | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 2 | Effects of hyperglycemia on neurologie outcome in stroke patients 显示文摘 | Paolino A S Garner K M | 2005 | Neurosci Nuts2005，37，3： | 1 |
| 3 | Simulation of the re- cent multidecadel increase of Atlantic hurricane activity using an 18 kin-grid regional model显示文摘 | Knutson T R Sirutis J J Garner S T | | 0，，： | 1 |
| 4 | The place of eprints in scholarly information delivery显示文摘 | Garner J Horwood L Sullivan S | 2001 | Online Information Review2001，25，4： | 1 |
| 5 | Dustbathing by broiler chickens: A comparison of preference for four different substrates显示文摘 | Shields S J J P Garner J A Meneh | 2004 | Appl Anim Behav Sci2004，87，： | 1 |
| 6 | Synthesis of tert-butoxycarbonyl (boc)- protected purines 显示文摘 | Dey S Garner P | 2000 | J Org Chem2000，65，22： | 1 |
| 7 | Effect of sand and wood --shavings beddingon the behavior of broiler ehiekens显示文摘 | Shields S J J P Garner J A Mench | 2005 | Poultry Science2005，84，： | 1 |
| 8 | Natural variations in the abundance ratio and the atomic weight of copper显示文摘 | Shield W R Goldich S S Garner E L | 1965 | J Geophys Res1965，70，： | 1 |
| 9 | Is herniography useful?显示文摘 | Garner JP Patel S Glares J | 2006 | Hernia2006，10，1： | 1 |
| 10 | Circumstances of death in sudden death in epilepsy: interviews of bereaved xelatrces显示文摘 | Nashef L Garner S Sander J W A S | 1998 | J Neurol Neurosurg Psychialt1998，64，： | 1 |
| 11 | Physicalmap location of the Rp s1-kallele in soybean 显示文摘 | Garner M Ekhymowi T Z Tkxu S | 2001 | Crop Sei2001，41，： | 1 |
| 12 | Extraction of acid from water显示文摘 | Garner F H Ellis S R M Pearce C J | 1954 | Chem Eng Sci1954，3，2： | 1 |
| 13 | Acne vulgaris 显示文摘 | Williams HC Dellavalle RP Garner S | 2012 | The Lan- cet2012，379，： | 1 |
| 14 | CDC Guideline for handwashing and hospi tal environmental control显示文摘 | Garner J S Favero M S | 1986 | Infect Control1986，7，： | 1 |
| 15 | The extent and impact of sheep pox and goat pox in the state of Maharashtra,India显示文摘 | GARNER M SAWARKAR S D BRETT E K | 2000 | Trop Anlm Health Prod2000，32，4： | 1 |
| 16 | Irra diation creep and swelling from ,100 to 600 ℃ of the oxide dis persion strengthened ferritic alloy MA957 显示文摘 | TOLOCZKO M B GELLES D S GARNER F A | 2004 | Journal of Nu clear Materials2004，，1： | 1 |
| 17 | Betamimetics for in- hibiting preterm labour 显示文摘 | Anotayanonth S Subhedar NV Garner P | 2004 | Cochrane Database Syst Rev2004，18，00： | 1 |
| 18 | Identification of glutathionyl-3-hydroxynurenine glucoside as a novel fluorophore associated with ageing of the human lens 显示文摘 | Garner B Vazquez S Griffith R | 1999 | J Biol Chem1999，274，20： | 1 |
| 19 | An electronic nose for the monitoring of the flavour of beers显示文摘 | Pearce T C Garner J W Friel S Bartlett P N Blair N | 1993 | Analyst1993，118，： | 1 |
| 20 | Experimental investigation of low temperature dieselcombustion processes显示文摘 | Cong S McTaggart-Cowan G P Garner C P | 2011 | Combust Sci and Tech2011，183，： | 1 |
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