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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 3 | Besifloxacin,a novel fluoroquinolone,has broad-spectrum in vitro activity against aerobic and anaerobic bacteria显示文摘 | Haas W Chris M P Gary E Z | 2009 | Antimicrob Agents Chemother2009，53，8： | 1 |
| 4 | PET of Brain Amyloid and Tau in Mild Cognitive Impairment显示文摘 | Gary W Small M | 2006 | N Engl J Med2006，355，： | 1 |
| 5 | Framework for multidisciplinary integrated modelling and analysis of space telescopes显示文摘 | Alivier L W Gary E M | 2002 | Integrated Modeling of Telescopes2002，，： | 1 |
| 6 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 7 | Human breast cancer : correlation of relapse and survival with amplification of the Her-2/ neu oncogene 显示文摘 | Dennis J S Gary M C Stenven G W | 1987 | Science1987，235，4785： | 1 |
| 8 | A record of Muscodor al-bus, an endophyte from Myristica fragrans in Thailand显示文摘 | Kathawut S’Gary A S Hess W M | 2003 | Mycotax-on2003，88，： | 1 |
| 9 | Free fatty acid induced insulin resistance is associated with activation of protein kinase C and alterations in the insulin signaling cascade显示文摘 | Griffin M E Marcucci M J Gary W | 1999 | DIABETES1999，48，： | 1 |
| 10 | Adaptive phasedistortion correction based on parallel gradient-descent optimization显示文摘 | Vorontsov M A Gary W Carhart J C R | 1997 | Optics Letters1997，22，12： | 1 |
| 11 | MicroRNA-181b regulates NF-[kappa]B-mediated vascular inflammation显示文摘 | Sun Xinghui Icli Basak Wara Akm Khyrul Belkin Nathan He Shaolin Kobzik Lester Hunninghake Gary M Vera Miguel Pinilla Blackwell Timothy S Baron Rebecca M Feinberg Mark W | 2012 | EN2012，，： | 1 |
| 12 | Three distinct porosity domains defined physically, hydraulically, electrically, and elastically显示文摘 | WENDY W GARY M | 2001 | The Leading Edge2001，，2： | 1 |
| 13 | Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual显示文摘 | S.Eva Singletary Craig Allred Pandora Ashley Lawrence W Bassett Donald Berry Kirby I Bland Patrick I Borgen Gary M Clark Stephen B Edge Daniel F Hayes Lorie L Hughes Robert V.P Hutter Monica Morrow David L Page Abram Recht Richard L Theriault Ann Thor Don | 2003 | Surgical Clinics of North America2003，，4： | 1 |
| 14 | Bioavailability and bioefficaey of polyphends in humam, L Review of 97 bioavail ability studies显示文摘 | Claudine M Gary W Christine M | 2005 | Am J Clin Nutr2005，，： | 1 |
| 15 | Human breast cancer:correlation of relapse and survival with amplification of the HER2/neu oncogene显示文摘 | DENNIS J S GARY M C STENVEN G W | 1987 | Science1987，235，： | 1 |
| 16 | Nanoscale Patterning of Magnetic Islands by Imprint Lithography Using a Flexible Mold显示文摘 | MCCLELLAND Gary M HART Mark W RETTNE Charles T | 2002 | Applied Physics Letters2002，81，8： | 1 |
| 17 | Meta-Raps approach for the 0-1 Multidimensional Knapsack Problem显示文摘 | Reinaldo J M Gail W D Gary E | 2005 | Computers & Industrial Engineering2005，48，1： | 1 |
| 18 | Crop modeling in horticulture: state of the art显示文摘 | Gary C Jones J W Tchamitchian M | 1998 | Scientia Hort1998，74，12： | 1 |
| 19 | Glucosylation of the peptide leucinostatin A,produced by an endophytic funfus of European yew,may protect the host from leucinostatin toxicity显示文摘 | GARY A STROBEL W HESS M | 1997 | Chemistry and Biology1997，4，7： | 1 |
| 20 | Comparison of source apportionment and sensitivity analysis in a particulate matter air quality model 显示文摘 | BONYOUNG K GARY M W RALPH E M | 2009 | Environ Sci Technol2009，43，： | 1 |
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