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| 1 | Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases显示文摘AIM To investigate whether immune mediated diseases(IMD) are more frequent in patients with inflammatory bowel disease(IBD).METHODS In this population based registry study,a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16,2013. Controls were randomly selected from the Danish Civil Registration System(CRS) and matched for sex,age,and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis(UC),Crohn's disease(CD) and Both the latter referring to those registered with both diagnoses. Subsequently,odds-ratios(OR) and 95%CI were obtained separately for each group and their respective controls. The use of Bonferoni post-test correction adjusted the significance level to P < 0.00125. P-values were estimated using Fisher's exact test.RESULTS There were significantly more women than men in the registry,and a greater percentage of comorbidity in the IBD groups(P < 0.05). Twenty different IMDs were all significantly more frequent in the IBD group. Sixteen were associated with UC versus twelve with CD. In both UC and CD ORs were significantly increased(P < 0.00125) for primary sclerosing cholangitis(PSC),celiac disease,type 1 diabetes(T1D),sarcoidosis,asthma,iridocyclitis,psoriasis,pyoderma gangrenosum,rheumatoid arthritis,and ankylosing spondylitis. Restricted to UC(P < 0.00125) were autoimmune hepatitis,primary biliary cholangitis,Grave's disease,polymyalgia rheumatica,temporal arteritis,and atrophic gastritis. Restricted to CD(P < 0.00125) were psoriatic arthritis and episcleritis. Restricted to women with UC(P < 0.00125) were atrophic gastritis,rheumatoid arthritis,temporal arteritis,and polymyalgia rheumatica. Restricted to women with CD were episcleritis,rheumatoid arthritis,and psoriatic arthritis. The only disease restricted to men(P < 0.00125) was sarcoidosis. CONCLUSION Immune mediated diseases were significantly more frequent in patients with IBD. Our results strengthen the hypothesis that some IMDs and IBD may have overlapping pathogenic pathways. | Morten L Halling Jens Kjeldsen Torben Knudsen Jan Nielsen Lars Koch Hansen | 2017 | World Journal of Gastroenterology2017，23，33： | 9 |
| 2 | Liver Transplantation for Nonresectable Liver Metastases From Colorectal Cancer显示文摘 | Morten Hagness Aksel Foss P?l-Dag Line Tim Scholz P?l Foyn J?rgensen Bjarte Fosby Kirsten Muri Boberg ?ystein Mathisen Ivar P. Gladhaug Tor Skatvedt Egge Steinar Solberg John Hausken Svein Dueland | 2013 | Annals of Surgery2013，，5： | 4 |
| 3 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 4 | Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts显示文摘 | Morten KJ Badder L Knowles HJ | 2013 | J Pathol2013，229，5： | 1 |
| 5 | Comparison of microglia and infiltrating CD1 lc~cells as antigen presenting cells for T cell- proliferation and cytokine response 显示文摘 | Agnieszka W Morten L Oriane C | 2014 | Neuroinflammation2014，11，： | 1 |
| 6 | 显示文摘 | ALEXANDRE H MORTEN L | 1998 | Journal of Molecular Modeling1998，4，： | 1 |
| 7 | Catheter-directed Venous Thrombolysis in acute iliofemoral vein thrombosis-the CaVenT Study: Rationale and design of a multicenter, randomized, controlled, clinical trial (NCT00251771)显示文摘 | Tone Enden Leiv Sandvik Nils-Einar Kl?w Geir Hafsahl P?l Andre Holme Lars Olaf Holmen Waleed Ghanima Anne Mette Njaastad Gunnar Sandb?k Carl-Erik Slagsvold Per Morten Sandset | 2007 | American Heart Journal2007，，5： | 1 |
| 8 | Blades of olivines and orthopyroxenes in uhramafic rocks from the Cerro del Almirez, Sierra Nevada Complex ,Spain: relics of quench-textured harzburgites ? 显示文摘 | Morten L Puga E | 1984 | Neues Jahr-buch fur Mineralogle Monatshefte1984，5，： | 1 |
| 9 | Enhancement of human adaptive immune responses by administration of a high- molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis显示文摘 | MORTEN L WALSTED A LARSEN R | 2008 | J Med Food2008，11，2： | 1 |
| 10 | Inhibition of microRNA function by antimiR oligonucleotides 显示文摘 | Jan S Andreas P Morten L | 2012 | Silence2012，3，： | 1 |
| 11 | Evidence for multi stage metasomatism of chlorite-amphibole peridotites (Ulten Zone, Italy): Constraints from trace element compositions of hydrous phases显示文摘 | MAROCCHI M HERMANN J MORTEN L | 2007 | Lithos2007，99，12： | 1 |
| 12 | Safety and feasibility of a combined exercise intervention for inoperable lung cancer patients undergoing chemotherapy: a pilot study显示文摘 | Morten Q Seppo L Mikael R | 2012 | Lung Cancer2012，19，75： | 1 |
| 13 | Physical and virtual tools:activity theory applied to the design of groupware 显示文摘 | MORTEN O F KRISTINA L MARTIN B | 2002 | Computer Supported Cooperative Work2002，11，12： | 1 |
| 14 | Controlled release of biocide from silica microparticles in wood paint显示文摘 | Scrensena G Nielsena A L Morten M P | | 0，，04： | 1 |
| 15 | Catheter-directed Venous Thrombolysis in acute iliofemoral vein thrombosis-the CaVenT Study: Rationale and design of a multicenter, randomized, controlled, clinical trial (NCT00251771)显示文摘 | Tone Enden Leiv Sandvik Nils-Einar Kl?w Geir Hafsahl P?l Andre Holme Lars Olaf Holmen Waleed Ghanima Anne Mette Njaastad Gunnar Sandb?k Carl-Erik Slagsvold Per Morten Sandset | 2007 | American Heart Journal2007，，5： | 1 |
| 16 | Efficient synthesis of 2,5-diketopiperazines using microwave assisted heating显示文摘 | Marcus T Morten G Kristina L | | 0，，： | 1 |
| 17 | Phase II study of Bevacizumab and Temsirolimus combination therapy for recurrent glioblastoma multiforme显示文摘 | ULRIK L MORTEN S TINE B | 2013 | Anticancer Res2013，33，4： | 1 |
| 18 | Detecting mental disorders in general hospitals by the SCL-8 scale显示文摘 | Per Fink Eva ?rnb?l Morten Steen Hansen Lene S?ndergaard Peter De Jonge | 2004 | Journal of Psychosomatic Research2004，，3： | 1 |
| 19 | Wide area system monitoring and control-terminology,phenomena,and solution implementa-tion strategies 显示文摘 | DANIEL K MORTEN H STURE L | 2004 | IEEE Power & Energy Magazine2004，13，5： | 1 |
| 20 | Forms of knowledge and modes of innovation 显示文摘 | MORTEN B J BJORN J EDWARD L | 2007 | Research Policy2007，，5： | 1 |
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