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87篇 您的检索式：作者名="Gaston G"

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	题名	作者	年代	出处	被引量
1	Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model显示文摘AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect.	Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine Rousseau Pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol	2016	World Journal of Hepatology2016，8，21：	5
2	Pharmacokinetics of daclizumab and mycophenolate mofetil with cyclosporine and steroids in renal transplantation 显示文摘	Pescovitz MD Bumgardner G Gaston RS	2003	Clin Transplant2003，17，6：	1
3	Human papillomaviruses and their role in cervical cancer显示文摘	Dell G Gaston K	2001	Cell Mol Life Sci2001，58，1213：	1
4	Human papllomavirus and their role in cervical cancer显示文摘	Dell G Gaston K	2001	Cell Mol Life Sei2001，58，123：	1
5	Human papillomaviruses and their role in cervical cancer显示文摘	DELL G GASTON K	2001	Cell Mol Life Sci2001，58，1213：	1
6	Human papillomaviruses and their role in cervical cancer显示文摘	Dell G Gaston K	2001	Cell Mol Life Sci2001，58，1213：	1
7	Contributions in the domain of cancer research: review human papillomaviruses and their role in cervical cancer显示文摘	Dell G Gaston K	2001	CMLS2001，58，：	1
8	Humanpapillo maviruses and their role in cervical cancer显示文摘	Dell G Gaston K	2001	Cell Mol Life Sci2001，58，1213：	1
9	Human papllomavirus and their role in cervical cancer显示文摘	DELL G GASTON K	2001	Cell Mol Life Sei2001，58，123：	1
10	Anaerobic killingof mucoid Pseudomonas aeruginosa by acidified nitrite derivativesunder cystic fibrosis airway conditions显示文摘	Yoon S S Coakley R Lau G W Lymar S V Gaston B Karabulut A C Hennigan R F Hwang S H Buettner G Schurr M J	2006	Journal of ClinicalInvestigation2006，116，2：	1
11	Contributions in the domain of cancer research: human papillomavirus and their role in cervical cancer显示文摘	DELL G GASTON K	2001	Cell Mol life Sci2001，58，：	1
12	Hyperspectral imaging for non-contact analysis of forensic traces显示文摘	EDELMAN G J GASTON E van LEEUWEN T G	2012	Forensic Science International2012，223，13：	1
13	Human papilloraaviruses and their role in cer- vicalcancer显示文摘	Dell G Gaston K	2001	Cell Mol Life Sci2001，58，1213：	1
14	Human papillomavir uses and their role in cervical cancer显示文摘	Dell G Gaston K	2001	Cell Mol Life Sci2001，58，1213：	1
15	Humanpapillo maviruses and their role in cervical cancer显示文摘	DELL G GASTON K	2001	Cell Mol Life Sci2001，58，1213：	1
16	Lateral condyle fracture of a child's humerus:the radiographic features may be subtle显示文摘	Gaston M S Irwin G J Huntley J S	2012	Scott Med2012，57，3：	1
17	State and change in carbon pools in the forests of tropical Africa 显示文摘	Gaston G Brown S Lorenzini M	1998	GlobalChange Biology1998，4，1：	1
18	Contributions in the domain of cancer research: Review Human papillomaviruses and their role in cervical cancer 显示文摘	Dell G Gaston K	2001	CMLS2001，58，12：	1
19	The integration of simulation and response surface methodology for the optimization of IC processes显示文摘	Gaston G J Walton A J	1994	IEEE Trans Semicon Manufac1994，7，1：	1
20	Human papillo maviruses and their role in cervical cancer显示文摘	DELL G GASTON K	2001	Cell Mol Life Sei2001，58，1213：	1

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