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| 1 | Intra-hepatic and extra-hepatic cholangiocarcinoma:New insight into epidemiology and risk factors显示文摘Cholangiocarcinoma(CCA) is a malignant tumour that arises from biliary epithelium at any portion of the biliary tree.CCA is currently classified as intra-hepatic or extra-hepatic CCA(EH-CCA).Recent evidences suggest that intra-hepatic CCA(IH-CCA) and EH-CCA are biologically different cancers,giving further support to a number of recent epidemiological studies showing large differences in terms of incidence,mortality and risk factors.The purpose of this manuscript is to review recent literature dealing with the descriptive epidemiology and risk factors of CCA with a special effort to compare IH-with EH-CCA. | Vincenzo Cardinale Rossella Semeraro Alessia Torrice Manuela Gatto Cristina Napoli Maria Consiglia Bragazzi Raffaele Gentile Domenico Alvaro | 2010 | World Journal of Gastrointestinal Oncology2010，2，11： | 12 |
| 2 | Preemptive mechanical ventilation can block progressive acute lung injury显示文摘Mortality from acute respiratory distress syndrome(ARDS) remains unacceptable, approaching 45% in certain high-risk patient populations. Treating fulminant ARDS is currently relegated to supportive care measures only. Thus, the best treatment for ARDS may lie with preventing this syndrome from ever occurring. Clinical studies were examined to determine why ARDS has remained resistant to treatment over the past several decades. In addition, both basic science and clinical studies were examined to determine the impact that early, protective mechanical ventilation may have on preventing the development of ARDS in at-risk patients. Fulminant ARDS is highly resistant to both pharmacologic treatment and methods of mechanical ventilation. However, ARDS is a progressive disease with an early treatment window that can be exploited. In particular, protective mechanical ventilation initiated before the onset of lung injury can prevent the progression to ARDS. Airway pressure release ventilation(APRV) is a novel mechanical ventilation strategy for delivering a protective breath that has been shown to block progressive acute lung injury(ALI) and prevent ALI from progressing to ARDS. ARDS mortality currently remains as high as 45% in some studies. As ARDS is a progressive disease, the key to treatment lies with preventing the disease from ever occurring while it remains subclinical. Early protective mechanical ventilation with APRV appears to offer substantial benefit in this regard and may be the prophylactic treatment of choice for preventing ARDS. | Benjamin Sadowitz Sumeet Jain Michaela Kollisch-Singule Joshua Satalin Penny Andrews Nader Habashi Louis A Gatto Gary Nieman | 2016 | World Journal of Critical Care Medicine2016，5，1： | 9 |
| 3 | Cardiac rehabilitation and mid-term follow-up after transcatheter aortic valve implantation显示文摘跟随大动脉的阀门培植(TAVI ) 通常基于的 transcatheter 的耐心的结果的 BackgroundEvaluation 幸存和临床的改进。生活的质量上的研究被限制,并且从在过程以后的全面评价的数据是在 TAVI 经历了在里面医院和在分泌物以后以后,病人们为心脏的康复提交了的 lacking.MethodsSixty 评估临床、功能、营养的地位的多维的评价,自治的度,认知缺陷,到康复的 life.ResultsOn 承认的消沉和质量,近似,病人的一半有严重功能的缺陷和依赖为在他们的医院停留期间,三分之一个个病人承受了重要临床的复杂并发症,二不得不被转移到培植中心。尽管有这,全面结果很好。所有留下的病人在分泌物是临床上稳定的,生活的功能的地位,自治和质量在大多数被改进。在 540 天的吝啬的后续期间(变化:192-738 天) ,五个病人从 noncardiac 原因死了,三为心脏的事件被就医,并且九为非心脏的原因。功能的地位和自治在病人的多数仍然保持令人满意,大多数继续到在 TAVI 经常是很脆弱的以后,为康复提交的实时 independently.ConclusionsPatients,与功能的缺陷,其它上的依赖和临床的复杂并发症的高风险的一个高等级。在一个康复计划期间,基于一个多维的评价和干预,大多数病人在功能的地位,生活的质量,和自治显示出重要改进,它在中间的后续期间在题目的多数仍然保持稳定。 | Renzo Zanettini Gemma Gatto Ileana Mori Maria Beatrice Pozzoni Stefano Pelenghi Luigi Martinelli Silvio Klugmann | 2014 | Journal of Geriatric Cardiology2014，11，4： | 8 |
| 4 | New insights on cholangiocarcinoma显示文摘Cholangiocarcinoma(CCA) is a devastating cancer arising from the neoplastic transformation of the biliary epithelium.It is characterized by a progressive increase in incidence and prevalence.The only curative therapy is radical surgery or liver transplantation but,unfortunately,the majority of patients present with advanced stage disease,which is not amenable to surgical therapies.Recently,proposed serum and bile biomarkers could help in the screening and surveillance of categories at risk and in diagnosing CCA at an early stage.The molecular mechanisms triggering neoplastic transformation and growth of biliary epithelium are still undef ined,but signif icant progress has been achieved in the last few years.This review deals with the most recent advances on epidemiology,biology,and clinical management of CCA. | Manuela Gatto Domenico Alvaro | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 5 |
| 5 | Research and development of VUV optical coatings for micro mirror applications显示文摘This paper deals with vacuum UV optical coatings for micro mirror applications. High reflecting low-stress optical coatings have been developed for the next-generation of micro mechanical mirrors. The optimized metal systems are applicable in the VUV spectral region and can be integrated in the technology of MOEMS, such as spatial light modulators (SLM) and micro scanning mirrors. | Alexandre Gatto Norbert Kaiser | 2005 | 光学精密工程2005，13，4： | 4 |
| 6 | Critical endpoint and inverse magnetic catalysis for finite temperature and density quark matter in a magnetic background显示文摘 | M. Ruggieri L. Oliva P. Castorina R. Gatto V. Greco | 2014 | Physics Letters B2014，，： | 2 |
| 7 | Fuel cell performance assessment for closed-loop renewable energy systems显示文摘Fuel cells and electrolysis are promising candidates for future energy production from renewable energy sources. Usually, polymer electrolyte fuel cell systems run on hydrogen and air, while the most of electrolysis systems vent out oxygen as unused by-product. Replacing air with pure oxygen, fuel cell electrochemical performance, durability and system efficiency can be significantly increased with a further overall system simplification and increased reliability. This work, which represents the initial step for pure H_2/O_2 polymer electrolyte fuel cell operation in closed-loop systems, focuses on performance validation of a single cell operating with pure H_2/O_2 under different relative humidity(RH) levels, reactants stoichiometry conditions and temperature. As a result of this study, the most convenient and appropriate operative conditions for a polymer electrolyte fuel cell stack integrated in a closed loop system were selected. | Fabio V.Matera Irene Gatto Assunta Patti Enza Passalacqua | 2016 | Journal of Energy Chemistry2016，25，3： | 2 |
| 8 | Robust speed and torque estimation in electrical drives by second -order sliding modes显示文摘 | Bartolini G Damiano A Gatto G | 2003 | IEEE Transactions on Control Systems Technology2003，11，1： | 2 |
| 9 | 3D printing technique applied to rapid casting显示文摘 | Elena Bassoli Andrea Gatto Luca Iuliano Maria Grazia Violante | 2007 | Rapid Prototyping Journal2007，，3： | 2 |
| 10 | Quality of Life and Physical Activity in Liver Transplantation Patients: Results of a Case-Control Study in Italy显示文摘 | D. Masala A. Mannocci B. Unim A. Del Cimmuto F. Turchetta G. Gatto R. Santoro G.M. Ettorre A. Boccia G. La Torre | 2012 | Transplantation Proceedings2012，，5： | 2 |
| 11 | Cholangiocarcinoma: Update and future perspectives显示文摘 | Manuela Gatto Maria Consiglia Bragazzi Rossella Semeraro Cristina Napoli Raffaele Gentile Alessia Torrice Eugenio Gaudio Domenico Alvaro | 2010 | Digestive and Liver Disease2010，，4： | 2 |
| 12 | β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas:role in the regulation of response to somatostatin analogue treatment in patients with acromegaly显示文摘Recent in vitro studies highlighted G protein-coupled receptor kinase(GRK)2 andβ-arrestins as important players in driving somatostatin receptor(SSTR)desensitization and trafficking.Our aim was to characterize GRK2 andβ-arrestins expression in different pituitary adenomas and to investigate their potential role in the response to somatostatin analog(SSA)treatment in GHsecreting adenomas(GHomas).We evaluated mRNA expression of multiple SSTRs,GRK2,β-arrestin 1,andβ-arrestin 2 in 41pituitary adenomas(31 GHomas,6 nonfunctioning[NFPAs],and 4 prolactinomas[PRLomas]).Within the GHomas group,mRNA data were correlated with the in vivo response to an acute octreotide test and with the GH-lowering effect of SSA in cultured primary cells.β-Arrestin 1 expression was low in all 3 adenoma histotypes.However,its expression was significantly lower in GHomas | Gatto F Feelders R van der Pas R Kros JM Dogan F van Koetsveld PM van der Lelij AJ Neggers SJ Minuto F de Herder W Lamberts SW Ferone D Hofland LJ | 2013 | 中国神经肿瘤杂志2013，11，4： | 2 |
| 13 | Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures显示文摘二进制不对称的 nanocrystals (BNC ) ,加入的光敏的 TiO 2 nanorod 填写了 superparamagnetic -Fe2O3 球形的领域,在聚乙烯乙二醇被嵌入修改 phospholipid micelle 并且成功地 bioconjugated 到包含一个 RGD 主题的合适设计的肽。BNC 表示由于在一个粒子的二个不同领域的共存,相关多功能的 nanomaterial 由高 photoactivity 和磁性描绘了,那特别地在生物成像用作光线疗法和过高热代理人以及一根磁性的探针被适合。我们选择了 RGD 主题以便指向在激活的 endothelial 房间和癌症房间的几种类型上表示的 integrin。准备 RGD-peptide/BNC 结合,包括地由使用互补光、结构的技术监视了,在生物媒介表明了高稳定性和一致可分散性。RGD-peptide/BNC 的 cytotoxicity 结合在 vitro 被学习。RGD 肽的细胞的举起在房间结合,在房间 lysates 借助于二条不同途径,也就是共焦的显微镜学分析和排放光谱学决心估计了, RGD-peptide-BNC 的显示的选择为 v3 integrin 结合。这些 RGD-peptide-BNC 结合为癌症的 theranostic 治疗有一个高潜力。 | Gianpiero Valente Nicoletta Depalo Ivan de Paola Rosa Maria lacobazzi Nunzio Denora Valentino Laquintana Roberto Comparelli Emiliano Altamura Tiziana Latronico Michele Altomare Elisabetta Fanizza Marinella Striccoli Angela Agostiano Michele Saviano Annarita Del Gatto Laura Zaccaro Maria Lucia Curri | 2016 | Nano Research2016，9，3： | 2 |
| 14 | One-year follow-up of epithelial corneal cell sheet allografts mounted on platelet poor plasma in rabbits 显示文摘 | Luengo Gimeno F Lavigne V Gatto S Croxatto JO Correa L Gallo JE | 2009 | Mol Vis2009，15，： | 1 |
| 15 | Brachial artery vasoreactivity is associated with cross-sectional and longitudinal anatomical measures of atherosclerosis in postmenopausal women with coronary artery disease 显示文摘 | Gatto NM Hodis HN Liu CR | 2008 | Atherosclerosis2008，196，： | 1 |
| 16 | Brachial artery vasoreactivity is associated with cross-sectional an6 lon- gitudinal anatomical measures of atherosclerosis in post- menopausal women with coronary artery disease显示文摘 | Gatto N M Hodis H N Liu C R | 2008 | Atherosclerosis2008，196，2： | 1 |
| 17 | Soil freeze-thaw-induced changes to a simulated rill: Potential impacts on soil erosion显示文摘 | Gatto L W | 2000 | Geomorphology2000，32，1： | 1 |
| 18 | Airway pressure release ventilation prevents ventilator-induced lung injury in nor- mal lungs显示文摘 | Emr B Gatto LA Roy S | 2013 | JAMA Surg2013，148，11： | 1 |
| 19 | Unlaerallaminectomy for bi-lateral decompression of lumbar spinal stenosis:a prospective sturywith conserva- tively treated patients 显示文摘 | Mariconda M Fava R Gatto A | 2002 | J Spinal Disord Tech2002，1，： | 1 |
| 20 | Impact strength of nogueira-pecawood on different moisture conditions显示文摘 | Beltrame R Mattos B D Gatto D A | 2012 | Ciencia Rural2012，42，9： | 1 |
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