|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China显示文摘Importance:Neuroblastoma is the most common extracranial malignant solid tumor in children.Multidisciplinary care is critical to improving the survival of pediatric patients with neuroblastoma.Objective:To systematically summarize the clinical characteristics of children with neuroblastoma and evaluate their prognosis with multidisciplinary care provided in a single center.Methods:This retrospective study analyzed the clinical data of 1041 patients with neuroblastoma who were diagnosed,treated,and followed-up in the Hematology-Oncology Center of Beijing Children’s Hospital from 2007 to 2019.Results:The median age at diagnosis was 34 months;80.8%of the patients were younger than 5 years of age.Notably,243 patients(23.3%)were classified as low-risk,249 patients(23.9%)were classified as intermediate-risk,and 549(52.7%)were classified as high-risk.Furthermore,956 patients underwent surgical resections;986(94.7%)patients received chemotherapy;and 176 patients with high-risk neuroblastoma received hematopoietic stem cell transplantation.The 5-year event-free survival(EFS)rate was 91.3%and 5-year overall survival(OS)rate was 97.5%in low-risk group;in the intermediate-risk group,these rates were 85.1%and 96.7%,respectively,while they were 37.7%and 48.9%in the high-risk group(P<0.001 for both).The 5-year EFS and OS rates were significantly higher in patients diagnosed between 2015 and 2019 than in patients diagnosed between 2007 and 2014(P<0.001).In total,278 patients(26.7%)exhibited tumor relapse or progression;the median interval until relapse or progression was 14 months.Of the 233 patients who died,83%died of relapse or progression of neuroblastoma and 4.3%died of therapy-related complications.Interpretation:The 5-year OS rate was low in high-risk patients,compared with low-and intermediate-risk patients.Multidisciplinary care is critical for improvement of survival in pediatric patients with neuroblastoma.Additional treatment strategies should be sought to improve the prognosis of patients with high-risk neuroblastoma. | Yan Su Hong Qin Chenghao Chen Shengcai Wang Shihan Zhang Dawei Zhang Mei Jin Yun Peng Lejian He Xiaoman Wang Suyun Qian Maoquan Qin Ming Ge Fuquan Zhang Qi Zeng Huanmin Wang Xiaoli Ma Xin Ni | 2020 | Pediatric Investigation2020，4，3： | 16 |
| 2 | Effects of dietary vitamin E on muscle vitamin E and fatty acid content in Aohan fine-wool sheep显示文摘value for consumers. Several laboratories have evaluated the effects of vitamin E on the fatty acid(FA) composition of muscle in sheep. However, little information is available on wool sheep, even though wool sheep breeds are an important source of mutton, especially in northern China where sheep are extensively farmed. The present study was designed to address the effects of vitamin E on muscle FA composition in male Aohan fine-wool sheep. Methods: Forty-two male Aohan fine-wool lambs(5 mo old) with similar initial body weight were randomly divided into seven groups and fed diets supplemented with 0(control group), 20, 100, 200, 1,000, 2,000, or 2,400 IU/sheep/d vitamin E for 12 mo. Three lambs from each group were slaughtered to measure vitamin E and FA content in the longissimus lumborum(LL) and gluteus medius(GM) muscles. Results: Vitamin E concentrations in the LL and GM increased significantly after 12 mo of vitamin E supplementation(P < 0.05). However, this increase did not occur in a dose-dependent manner because the muscle vitamin E concentration was highest in the 200 IU/sheep/d group. Dietary vitamin E supplementation also caused a significant reduction in SFA content and an increase in monounsaturated FA(MUFA) content in the LL and GM(P < 0.05). All six doses of vitamin E significantly increased cis9 trans11-conjugated linoleic acid(c9t11-CLA) content in the LL compared with the control group(P < 0.05). Conclusions: Dietary supplementation with vitamin E increased muscle vitamin E content and improved the nutritional value of mutton by decreasing SFA content and increasing MUFA and c9t11-CLA contents in Aohan fine-wool sheep. These effects were greatest in sheep fed a diet containing 200 IU/sheep/d vitamin E. | Kun Liu Suyun Ge Hailing Luo Dubing Yue Leyan Yan | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 6 |
| 3 | Brief Introduction to the 'Catalogue of Recent Chinese Earthquakes (1912~1990, M_S≥4.7)显示文摘This paper briefly introduces the principles and methods for compiling the 'Catalog of Recent Chinese Earthquakes (1912 ~ 1990, MS≥4.7).' This new catalog is compiled by revising and supplementing the 1983 version of the Catalog of Chinese Earthquakes. | Wang Suyun, Wu Ge, Shi Zhenliang, Li Qun, Zhai Wenjie, Gao Ajia, Wu Huanying, Guo Ying, and Zhang XiaodongInstitute of Geophysics, CSB, Beijing 100081, ChinaSeismological Bureau of Liaoning Province, Shenyang 110031, China | 1999 | Earthquake Research in China1999，13，1： | 4 |
| 4 | Exploration of Development Trend of Antibiotics Based on the 'Fast-growing Chicken' Incident显示文摘Antibiotics play an important role in livestock breeding,such as promoting animals' growth and keeping their fitness,however,the residues easily cause food security problems.This paper analyzed application status of antibiotics from the perspectives of reasons for application,dangers,foreign and domestic supervision policies and so on,and proposed origanum oil as the substitute of antibiotics by elaborating its action mechanism and application prospects. | Tao Chunwei Ge Suyun Liu Chunhai | 2015 | Animal Husbandry and Feed Science2015，7，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员