|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment显示文摘AIM: To assess the antioxidant and antifibrotic effects of long-term Ginkgo biloba administration on liver fibrosis induced by biliary obstruction in rats.METHODS: Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL). Ginkgo administered for 28 d. At the end of the treatment period,all rats were killed. Serum aspartate aminotransferase (AST),alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined to assess liver functions and tissue damage, respectively. Tumor necrosis factor-α (TNF-α) was also assayed in serum samples. Liver tissues were taken for determination of the hepatic malondialdehyde (MDA) and glutathione (GSH) levels,myeloperoxidase (MPO) activity and collagen content.Production of reactive oxidants was monitored by chemiluminescence (CL) assay. Serum AST, ALT, LDH, and TNF-α levels were elevated in the BDL group as compared to control group and were significantly decreased by EGb treatment.RESULTS: Hepatic GSH level, depressed by BDL, was elevated back to control level in EGb-treated BDL group.Increase in tissue MDA level, MPO activity and collagen content due to BDL were also attenuated by EGb treatment.Furthermore, luminol and lucigenin CL values in BDL group increased dramatically compared to control and reduced by EGb treatment.CONCLUSION: Our results suggest that Ginkgo biloba protects the liver from oxidative damage following BDL in rats. This effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue. | Gksel pener Levent Kabasakal Meral Yüksel Nursal Gedik Ynci Alican | 2005 | World Journal of Gastroenterology2005，11，35： | 7 |
| 2 | Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion 显示文摘 | Heusch G Musiolik J Gedik N | 2011 | Circ Res2011，109，11： | 1 |
| 3 | Askin' s tumor in an adult: case report and findings on 18 F- FDG PET/CT 显示文摘 | Kara Gedik G Sari O Altinok T | 2009 | Case Rep Med2009，2009，51： | 1 |
| 4 | Effects of age and dietary restriction on oxidative DNA damage, antiox- idant protection and DNA repair in rats显示文摘 | Gedik C M Grant G Mortice P C | 2005 | European Journal of Nutrition2005，44，5： | 1 |
| 5 | Mitochondrial STAT3 activation and cardioprotection by ischemic postcondi- tioning in pigs with regional myocardial ischemia/reperfusion 显示文摘 | HEUSCH G MUSIOLIK J GEDIK N | 2011 | Circ Res2011，109，11： | 1 |
| 6 | Askin's Tumor in an Adult:Case Report and Findings on 18F-FDG PET/CT 显示文摘 | Kara Gedik G Sari O Altinok T | 2009 | Case Report Med2009，，： | 1 |
| 7 | Rosiglitazone, a PPARγ ligand, protects against burn-induced oxidative injury of remote organs 显示文摘 | Sener G Sehirli AO Gedik N | 2007 | Bums2007，33，5： | 1 |
| 8 | Has Helicobacter pylori eradication therapy any effect on severity of rosanes symptoms?显示文摘 | GEDIK G K KARADUMAN A SIVRI B | 2005 | J Eur Acad Dermatol Venereol2005，19，3： | 1 |
| 9 | Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion 显示文摘 | Heusch G Musiolik J Gedik N | 2011 | C irc Res2011，109，11： | 1 |
| 10 | The protective effect of oxytocin on renal ischemia/ reperfusion injury in rats显示文摘 | Tugtepe H Sener G Biyikli N K Yuksel M Cetinel S Gedik N | 2007 | Regul Pept2007，140，： | 1 |
| 11 | Askin's tumor in an adult:case report and findings on 18F-FDG PET/CT显示文摘 | Kara Gedik G Sari O Altinok T | | 0，，： | 1 |
| 12 | Estrogen protects the liver and intestines against sepsis-induced injury in rats显示文摘 | Sener G Arbak S Kurtaran P Gedik N Ye Sen B C | 2005 | J Surg Res2005，128，： | 1 |
| 13 | Prediction of building envelope performance in the design stage:an application for office buildings显示文摘 | Unver R Akdag N Y Gedik G Z | 2004 | Building and Environment2004，39，2： | 1 |
| 14 | An atypical case of idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) syndrome 显示文摘 | Gedik S Yilmaz G Akca S Akova YA | 2005 | Eye2005，19，4： | 1 |
| 15 | Frequency of severe hypoglycaemia in type 1 and type 2 diabetes during conventional insulin therapy显示文摘 | Gürlek A Erbas T Gedik O | 1999 | Exp Clin Endocrinol Diabetes1999，107，3： | 1 |
| 16 | Research trends in mobile assis- ted language learning from 2000 to 2012 显示文摘 | Duman G Orhon G Gedik N | 2014 | RECALL2014，，2： | 1 |
| 17 | Indocyanine green and fundus fluorescein angiographic findings in patients with active ocular Behcet's disease显示文摘 | Gedik S Akova Y Yilmaz G | 2005 | Ocul Immunol Inflamm2005，13，1： | 1 |
| 18 | Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion显示文摘 | Heusch G Musiolik J Gedik N | 2011 | Circul Res2011，109，11： | 1 |
| 19 | Impact of Chronic Pre-Treatment of Statins on the Level of Systemic Inflammation and Myocardial Perfusion in Patients Undergoing Primary Angioplasty显示文摘 | Vecih Oduncu Ali Cevat Tanalp Ayhan Erkol Dicle S?rma Cihan Dündar Taylan Akgün Erdem Türky?lmaz Alev K?l??gedik G?khan G?zübüyük Kür?at Tigen Ak?n Izgi Cevat K?rma | 2011 | The American Journal of Cardiology2011，，2： | 1 |
| 20 | Processing Moving Queries over Moving Objects Using Motion-adaptive Indexes 显示文摘 | GEDIK B G | 2006 | IEEE Transactions on Knowledge and Data Engineering2006，18，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员