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| 1 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 2 | Facile synthesis of Mo2C nanoparticles on N-doped carbon nanotubes with enhanced electrocatalytic activity for hydrogen evolution and oxygen reduction reactions显示文摘Developing low-cost and highly-efficient electrocatalysts for renewable energy conversion technologies has attracted even-increasing attention. Molybdenum carbide materials have recently emerged as a type of promising catalysts for electrocatalytic reactions due to the earth-abundance and Pt-resembled electrical properties. In this work, taking the advantage of the interaction between the basic groups of the Mo(VI)-melamine polymer and the acidic groups on the surface of the oxidized carbon nanotubes(CNTs), N-doped CNTs supported Mo2C nanoparticles(Mo2C/NCNT) are prepared, which exhibit outstanding electrocatalytic activity and durability for both the hydrogen evolution and oxygen reduction reactions. The impressive performance of Mo2C/NCNT can be attributed to the small size of Mo2C particles, the large exposure ratio of surface sites and the presence of N-doped CNTs. This work enlarges the multi-field applications of molybdenum carbide-base materials as promising non-precious metal electrocatalysts, which is of great significance for sustainable energy-related technologies. | Yue-Jun Song Jin-Tao Ren Gege Yuan Yali Yao Xinying Liu Zhong-Yong Yuan | 2019 | Journal of Energy Chemistry2019，28，11： | 2 |
| 3 | Development and Validation of a Nomogram for Prediction of the Risk of MAFLD in an Overweight and Obese Population显示文摘Background and Aims:Metabolic associated fatty liver disease(MAFLD)is a serious condition,and a simple meth-od is needed for practitioners to identify patients with the disease and have a high risk of disease progression.Meth-ods:We developed and validated a nomogram for fatty liver disease and reclassified the risk factors for MAFLD.The development cohort had 335 patients who received bioel-ectrical impedance analysis and liver ultrasound attenua-tion measurements at Shenzhen People’s Hospital between September 2020 and June 2021.The validation cohort had 200 patients from other hospitals who received the same evaluation.A random forest procedure and binary logistic analysis were used to screen for risk factors,establish a fatty liver disease predictive model,and forecast the risk of MAFLD.The performance of the nomogram was evaluated by measurement of discrimination,calibration,and clinical usefulness.Results:The nomogram provided good predic-tions in a model that included body mass index(BMI)and waist circumference.The areas under the curve of the nom-ogram were 0.793 in the development cohort and 0.774 in the validation cohort.The nomogram performed well for calibration,category-free net reclassification improvement,and integrated discrimination improvement.Decision curve analysis indicated the nomogram performed better than BMI for predicting net outcome.Conclusions:The nomo-gram was an effective screening tool for fatty liver disease,and for those overweight individuals,may help physicians make appropriate decisions regarding treatment of MAFLD. | Di Song Qian Ge Ming Chen Song Bai Xiaoshu Lai Gege Huang Mengmeng Liu Miaofang Lin Jinfeng Xu Fajin Dong | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 1 |
| 4 | Novel cyclophosphamide of natural products osalmide and pterostilbene induces cytotoxicity and cell cycle arrest in diffuse large B-cell lymphoma cells显示文摘Diffuse large B-cell lymphoma(DLBCL)is the most common category and disease entity of non-Hodgkin lymphoma.Osalmide and pterostilbene are natural products with anticancer activities via different mechanism.In this study,using a new synthetic strategy for the two natural products,we obtained the compound DCZ0801,which was previously found to have anti-multiple myeloma activity.We performed both in vitro and in vivo assays to investigate its bioactivity and explore its underlying mechanism against DLBCL cells.The results showed that DCZ0801 treatment gave rise to a dose-and time-dependent inhibition of cell viability as determined by CCK-8 assay and flow cytometry assay.Western blot analysis results showed that the expression of caspase-3,caspase-8,caspase-9 and Bax was increased,while BCL-2 and BCL-XL levels were decreased,which suggested that DCZ0801 inhibited cell proliferation and promoted intrinsic apoptosis.In addition,DCZ0801 induced G0/G1 phase arrest by downregulating the protein expression levels of CDK4,CDK6 and cyclin D1.Furthermore,DCZ0801 exerted an anti-tumor effect by down-regulating the expressions of p-PI3K and p-AKT.There also existed a trend that the expression of p-JNK and p-P38 was restrained.Intraperitoneal injection of DCZ0801 suppressed tum or development in xenograft mouse models.The preliminary metabolic study showed that DCZ0801 displayed a rapid metabolism within 30 min.These results demonstrated that DCZ0801 may be a new potential anti-DLBCL agent in DLBCL therapy. | Mengyu Xi Wan He Bo Li Jinfeng Zhou Zhijian Xu Huiqun Wu Yong Zhang Dongliang Song Liangning Hu Ye Lu Wenxuan Bu Yuanyuan Kong Gege Chen Shuaikang Chang Jumei Shi Weiliang Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 0 |
| 5 | antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway显示文摘Multiple myeloma(MM),the second most common haematological malignancy,is currently incurable because patients often develop multiple drug resistance and experience subsequent relapse of the disease.This study aims to identify a potential therapeutic agent that can counter bortezomib(BTZ)resistance in MM.DCZ0358,a novel alkaloid compound,is found to exert potent cytotoxic effects against BTZ-resistant MM cells in vivo and in vitro.The antimyeloma activity of DCZ0358 is associated with inhibition of cell proliferation,promotion of cell apoptosis via caspase-mediated apoptotic pathways,and induction of G0/G1 phase arrest via downregulation of cyclin D1,CDK4,and CDK6.Further investigation of the molecular mechanism shows that DCZ0358 suppresses the JAK2/STAT3 signaling pathway.In conclusion,DCZ0358 can successfully counter BTZ resistance in MM cells.This study provides evidence that warrants future preclinical assessments of DCZ0358 as a therapeutic agent against BTZ resistance in MM. | Bibo Zhang Bo Li Yongsheng Xie Shuaikang Chang Zhijian Xu Huifang Hu Gege Chen Ting Zhang Jun He Xiaosong Wu Huabin Zhu Weiming Lai Dongliang Song Ying Lu Xinyan Jia Weiliang Zhu Jumei Shi | 2023 | Acta Biochimica et Biophysica Sinica2023，55，2： | 0 |
| 6 | A novel silicone derivative of natural osalmid(DCZ0858)induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway显示文摘Diffuse large B-cell lymphoma(DLBCL)is a highly heterogeneous malignant tumor characterized by diffuse growth.DCZ0858 is a novel small molecule with excellent antitumor effects in DLBCL.This study explored in depth the inhibitory effect of DCZ0858 on DLBCL cell lines.Cell Counting Kit-8(CCK-8)and plate colony formation assays were used to evaluate cell proliferation levels.Flow cytometry was employed to analyze apoptosis and the cell cycle,and western blotting was used to quantify the expression of cell cycle regulators.The results indicated that DCZ0858 inhibited cell growth in a concentration-dependent and time-dependent manner while inducing no significant toxicity in normal cells.Moreover,DCZ0858 initiated cell apoptosis via both internal and external apoptotic pathways.DCZ0858 also induced cell cycle arrest in the G0/G1 phase,thereby controlling cell proliferation.Further investigation of the molecular mechanism showed that the JAK2/STAT3 pathway was involved in the DCZ0858-mediated antitumor effects and that JAK2 was the key target for DCZ0858 treatment.Knockdown of JAK2 partly weakened the DCZ0858-mediated antitumor effect in DLBCL cells,while JAK2 overexpression strengthened the effect of DCZ0858 in DLBCL cells.Moreover,a similar antitumor effect was observed for DCZ0858 and the JAK2 inhibitor ruxolitinib,and combining the two could significantly enhance cancer-suppressive signaling.Tumor xenograft models showed that DCZ0858 inhibited tumor growth in vivo and had low toxicity in important organs,findings that were consistent with the in vitro data.In summary,DCZ0858 is a promising drug for the treatment of DLBCL. | Kang Lu Bo Li Hui Zhang Zhijian Xu Dongliang Song Lu Gao Haiguo Sun Liping Li Yingcong Wang Qilin Feng Gege Chen Liangning Hu Rong Wei Yongsheng Xie Dandan Yu Xiaosong Wu Weiliang Zhu Jumei Shi | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 7 | Surface engineering of carbon dots for highly sensitive α-glucosidase assay and inhibition evaluation显示文摘Monitoringα-glucosidase(α-Glu)activity is of great significance for the early diagnosis of typeⅡdiabetes.Here the blue fluorescent carbon dots(CDs)were integrated with two different recognizing molecules,β-cyclodextrin and phenylboronic acid,for assembling a multifunctional CDs(mCDs)nanoplatform for sensitively analyzingα-Glu and its inhibitors.The hydrolyzed product of 4-nitrophenyl-α-D-glucopyranoside(α-Glu substrate),p-nitrophenol,could efficiently quench the fluorescence of mCDs due to its cooperative molecular recognition withβ-cyclodextrin and phenylboronic acid.The mCDs could be utilized for the detection ofα-Glu activity with the limit of detection of 0.030 U/L.Moreover,the presentα-Glu detection platform revealed a high selectivity,and other natural enzymes showed scarcely any effect on the present mCDs system.The proposed method could be facilely used to screenα-Glu inhibitors with satisfying performance.The rational mCDs is expected to supplement more comprehensive biosensing platforms for highly sensitive and specific recognition of disease-relevant biomarkers with clinical importance. | Meijuan Liang Gege Song Yeqing Wan Yingying Chen Fuan Wang Xiaoqing Liu | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 8 | Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation显示文摘Multiple myeloma(MM)is characterized by excessive aggregation of B-cell-derived malignant plasma cells in the hematopoietic system of bone marrow.Previously,we synthesized an innovative molecule named dihydrocelastrol(DHCE)from celastrol,a triterpene purified from medicinal plant Tripterygium wilfordii.Herein,we explore the therapeutic properties and latent signal transduction mechanism of DHCE action in bortezomib(BTZ)-resistant(BTZ-R)MM cells.In this study,we first report that DHCE shows antitumor activities in vitro and in vivo and exerts stronger inhibitory effects than celastrol on BTZ-R cells.We find that DHCE inhibits BTZ-R cell viability by promoting apoptosis via extrinsic and intrinsic pathways and suppresses BTZ-R MM cell proliferation by inducing G0/G1 phase cell cycle arrest.In addition,inactivation of JAK2/STAT3 and PI3K/Akt pathways are involved in the DHCE-mediated antitumor effect.Simultaneously,DHCE acts synergistically with BTZ on BTZ-R cells.PSMB5,a molecular target of BTZ,is overexpressed in BTZ-R MM cells compared with BTZ-S MM cells and is demonstrated to be a target of STAT3.Moreover,DHCE downregulates PSMB5 overexpression in BTZ-R MM cells,which illustrates that DHCE overcomes BTZ resistance through increasing the sensitivity of BTZ in resistant MM via inhibiting STAT3-dependent PSMB5 regulation.Overall,our findings imply that DHCE may become a potential therapeutic option that warrants clinical evaluation for BTZ-R MM. | Shuhan Jin Bo Li Bibo Zhang Xuejie Gao Xinyan Jia Li Xu Shuaikang Chang Ke Hu Guanli Wang Zhijian Xu Ting Zhang Dongliang Song Guang Yang Xiaosong Wu Huabin Zhu Cheng Huang Yumeng Lu Jumei Shi Weiliang Zhu Gege Chen | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
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