|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Polo-like kinase 1 expression is a prognostic factor in human colon cancer显示文摘AIM: To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1(PLK1) in colon cancer.METHODS: Expression of PLK1 was investigated by immunohistochemistry (158 cases) and immunoblotting in tissue of colon adenomas and adenocarcinomas. PLK1expression patterns were correlated with clinicopathological parameters and patient prognosis. In addition, expression of PLK1 was evaluated by immunoblot and PCR in colon carcinoma cell lines, and coexpression of PLK1 with the proliferation marker Ki-67 was investigated.RESULTS: Weak PLK1 expression was observed in normal colon mucosa and adenomas. In contrast, 66.7% of carcinomas showed strong expression of PLK1.Overexpression of PLK1 correlated positively with Dukes stage (P<0.001), tumor stage (P = 0.001) and nodal status (P<0.05). Additionally, PLK1 expression was a prognostic marker in univariate survival analysis (P<0.01) and had independent prognostic significance (RR = 3.3, P = 0.02)in patients with locoregional disease. Expression of PLK1 mRNA and protein was detected in all cell lines investigated. Coexpression of PLK1 and Ki-67 was observed in the majority of colon cancer cells, but a considerable proportion of cells showed PLK1 positivity without Ki-67expression.CONCLUSION: PLK1 is a new prognostic marker for colon carcinoma patients and may be involved in tumorigenesis and progression of colon cancer. Strategies focusing on PLK1 inhibition in vivo might therefore represent a promising new therapeutic approach for this tumor entity. | Wilko Weichert Glen Kristiansen Mathias Schmidt Volker Gekeler Aurelia Noske Silvia Niesporek Manfred Dietel Carsten Denkert | 2005 | World Journal of Gastroenterology2005，11，36： | 16 |
| 2 | Algae sequester heavy metals via synthesis of phytochelatin complexes显示文摘 | Walter Gekeler Erwin Grill Ernst-Ludwig Winnacker Meinhart H. Zenk | 1988 | Archives of Microbiology1988，，2： | 2 |
| 3 | Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer:a retrospective analysis显示文摘 | Weichert W Roske A Gekeler V | 2008 | Lancet Oncol2008，9，： | 1 |
| 4 | High ex- pression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis 显示文摘 | WEICHERT W BOEHM M GEKELER V | 2007 | Br JCancer2007，97，4： | 1 |
| 5 | 查看详情显示文摘 | Boer R Gekeler V | | 0，，： | 1 |
| 6 | High expression of RelA/p65 is associated with activation of nuclear factor kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis显示文摘 | Weichert W Boehm M Gekeler V | 2007 | Br J Cancer2007，97，4： | 1 |
| 7 | Aseptic loosening of cement-anchored total hip replacements显示文摘 | Aldinger G Gekeler J | 1982 | Arch Orthop Trauma Surg1982，100，1： | 1 |
| 8 | G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxy- nucleotides are potent suppressors of the growth of human tumor xenografts in nude mice 显示文摘 | GEKELER V GIMMNICH P HOFMANN H P | 2006 | Oligonucleotides2006，16，1： | 1 |
| 9 | Subretinal electrical stimulation of the rabbit retina with acutely implanted electrode arrays 显示文摘 | Gekeler F Kobuch K Schwahn HN Stett A Shinoda K Zrenner E | 2004 | Graefes Arch Clin Exp Ophthalmol2004，242，7： | 1 |
| 10 | Optimal alignment of mirror-based pentaprisms for scanning deflectometric devices显示文摘 | BARBER S K GEKELER R D YASHCHUK V V | 2011 | Optical Engineering2011，50，7： | 1 |
| 11 | Subretinal electrical stimulation of the rabbit retina with acutely implanted electrode arrays显示文摘 | Gekeler F Kobuch K Schwahn HN | 2004 | Graefe''s Arch Clin Exp Ophthalmol2004，242，7： | 1 |
| 12 | Protein kinase C isoenzymes,p53,accumulation of rhodamine 123,glutathione-S-transferase,topoisomerase Ⅱ and MRP inmultidrug resistant cell lines显示文摘 | Utz I Gekeler V Ise W | 1996 | Anticancer Res1996，16，1： | 1 |
| 13 | Com- pound subretinal prostheses with extra-ocular parts designed for human trials: successful long-term implantation in pigs 显示文摘 | GEKELER F SZURMAN P GRISANTI S | 2007 | Graefes Areh Clin Exp Ophthalmol2007，245，2： | 1 |
| 14 | Association of patterns of classⅠhistone deacetylase expression with patient prognosis in gastric cancer:a retrospective analysis显示文摘 | Weichert W Rske A Gekeler V | 2008 | Lancet Oncol2008，9，2： | 1 |
| 15 | Down-regulation of protein kinase Ceta by antisense oligonucleotides sensitises A549 lung cancer cells to vincristine and paclitaxel显示文摘 | Sonnemann J Gekeler V Ahlbrecht K | 2004 | Cancer Lett2004，209，2： | 1 |
| 16 | High expression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis显示文摘 | WEICHERT W BOEHM M GEKELER V | 2007 | Br J Cancer2007，97，4： | 1 |
| 17 | Aseptic loosening of qement an- chored total nip replacements显示文摘 | Aldinger G Gekeler J | 1982 | Arch Orthop Trauma Surg1982，100，1： | 1 |
| 18 | Down regulation of protein kinase Ceta by antisense oligonucleotides sensitizes A549 limg cancer to vincrisitine and paclitaxel 显示文摘 | Sonnemann J Gekeler V Ahlbrecht K | 2004 | Cancer Lett2004，209，2： | 1 |
| 19 | Intraocular lens power calculation and optimized constants for highly myopic eyes 显示文摘 | Petermeier K Gekeler F Messias A | 2009 | J Cataract Refract Surg2009，35，9： | 1 |
| 20 | Novel COL4A1 mutations associated with HANAC syndrome : a role for triple helical CB3 ( IV ) domain显示文摘 | Plaisier E Chen Z Gekeler F | 2010 | Am J Med Genet2010，152，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员